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Toplam kayıt 36, listelenen: 11-20
New Procaspase Activating Compound (PAC-1) Like Molecules as Potent Antitumoral Agents Against Lung Cancer
(Bentham Science Publ LTD, 2019)
Background: In this study, novel ortho-hydroxy N-acyl hydrazone moiety including compounds (3a-l) were designed, based on procaspase activating compound (PAC-1) which is a small molecule known with antitumor activity. The ...
New N'-Arylidene-2-[(4-Nitrophenyl) Piperazin-1-yl]Acetohydrazide Derivatives: Synthesis and Anticancer Activity Investigation
(Bentham Science Publ LTD, 2017)
Background: Compounds bearing ortho-hydroxy N-acyl hydrazone moiety have been reported with high anticancer activity acting by increasing the enzymatic activity of procaspase-3 in cancer cells and therefore inducing apoptosis ...
Synthesis and evaluation of new benzimidazole derivatives with hydrazone moiety as anticancer agents
(Walter De Gruyter GMBH, 2018)
Objectives: Cancer is one of the leading causes of death throughout the world. Current therapy options suffer from the major limitations of side effects and drug resistance. Thus, continuing search for newer and safer ...
Synthesis and biological evaluation of some hydrazone derivatives as new anticandidal and anticancer agents
(Elsevier France-Editions Scientifiques Medicales Elsevier, 2012)
New hydrazone derivatives were synthesized via the nucleophilic addition-elimination reaction of 2-[(1-methyl-1H-tetrazol-5-yl]thio)]acetohydrazide with aromatic aldehydes/ketones. The compounds were tested in vitro against ...
Synthesis and anticandidal evaluation of new benzothiazole derivatives with hydrazone moiety
(Taylor & Francis LTD, 2016)
In this study, we have performed the synthesis of new N-(arylidene)-4-[(benzothiazol-2-yl)thio]butanoylhydrazide derivatives (3a-s) bearing azole moiety and hydrazone group in a lipophilic structural framework. The target ...
Synthesis and evaluation of new benzoxazole derivatives as potential antiglioma agents
(Marmara University, 2018)
Gliomas account for the majority of human brain tumors and the incidence of gliomas is expected to rise in upcoming years and therefore extensive efforts have been devoted to the discovery of potent antiglioma agents. Due ...
Synthesis, Antituberculotic, and Cytotoxic Properties of New Hydrazone Derivatives Bearing Pyrimidine-Alkylsulfanyl Moiety
(Taylor & Francis LTD, 2015)
A series of N'-(arylidene)-4-[(pyrimidine-2-yl)thio]butanohydrazide derivatives (3a-3m) has been synthesized and investigated for their antituberculotic and cytotoxic activity. The antitubercular activities of the newly ...
Novel tetrazole derivatives: synthesis, anticholinesterase activity and cytotoxicity evaluation
(Walter De Gruyter GMBH, 2017)
Objective(s): The synthesis of new N'-arylidene-4-[(1phenyl- 1H-tetrazole-5-yl) thio] butanoylhydrazide derivatives (1-26) and investigation of their potential anticholinesterase (AChE), butyrylcholinesterase (BuChE) enzyme ...
Synthesis of New Fluoro-Benzimidazole Derivatives as an Approach towards the Discovery of Novel Intestinal Antiseptic Drug Candidates
(Bentham Science Publ LTD, 2017)
In the present study, nineteen new fluoro-benzimidazole derivatives, including nifuroxazide analogs, were synthesized by microwave-supported reactions and tested against a panel of pathogenic microorganisms consisting of ...
Synthesis and antimicrobial activity of some new hydrazone-bridged thiazole-pyrrole derivatives
(Taylor & Francis LTD, 2013)
In this work, we synthesized fourteen different compounds which contain hydrazone bridged thiazole and pyrrole rings. For this purpose, pyrrole-2-carboxaldehydes were reacted directly with thiosemicarbazide in ethanol and ...