Ara
Toplam kayıt 317, listelenen: 21-30
Novel tetrazole derivatives: synthesis, anticholinesterase activity and cytotoxicity evaluation
(Walter De Gruyter GMBH, 2017)
Objective(s): The synthesis of new N'-arylidene-4-[(1phenyl- 1H-tetrazole-5-yl) thio] butanoylhydrazide derivatives (1-26) and investigation of their potential anticholinesterase (AChE), butyrylcholinesterase (BuChE) enzyme ...
Synthesis and anti-cancer activity evaluation of new aurone derivatives
(Taylor & Francis LTD, 2015)
In this study, we have synthesized 2-[3-or 4-(2-aryl-2-oxoethoxy) arylidene] benzofuran-3-one derivatives (D1-D38) and evaluated their anti-cancer activities. The final compounds were obtained in multistep synthesis reactions ...
Synthesis and Biological Evaluation of Some 1,2-Disubstituted Benzimidazole Derivatives as New Potential Anticancer Agents
(Wiley-V C H Verlag GMBH, 2013)
The synthesis of some new 1-(2-aryl-2-oxoethyl)-2-[(morpholine-4-yl)thioxomethyl]benzimidazole derivatives and investigation of their anticancer activities were the aims of this work. 2-(Chloromethyl)benzimidazole compound ...
A preliminary investigation of anticancer activity of novel benzothiazole derivatives against A549 lung carcinoma cell line
(Walter De Gruyter GMBH, 2017)
Objective(s): In this study, it was aimed to synthesize new chemotherapeutic agents based on known antiproliferative properties of benzothiazol-2-amine moiety. The antitumor activity of the newly synthesized compounds was ...
Design, synthesis and evaluation of new thiazole-piperazines as acetylcholinesterase inhibitors
(Informa Healthcare, 2013)
In this study, some new 2-(4-substituted piperazine-1-yl)-N-[4-(2-methylthiazol-4-yl)phenyl]acetamide derivatives were synthesized. The synthesized compounds were screened for their anticholinesterase activity on ...
Synthesis and evaluation of novel 2-[(1,2,4-triazol-3-yl)thio]acetamide derivatives as potential serum paraoxonase-1 (PON1) activators
(Marmara University, Fac Pharmacy, 2017)
Coronary artery disease and low-density lipoprotein (LDL) levels in the blood have long been known to be associated with peripheral vascular diseases. Paraoxonase-1 (PON1) enzyme is related to serum levels of high-density ...
New N'-Arylidene-2-[(4-Nitrophenyl) Piperazin-1-yl]Acetohydrazide Derivatives: Synthesis and Anticancer Activity Investigation
(Bentham Science Publ LTD, 2017)
Background: Compounds bearing ortho-hydroxy N-acyl hydrazone moiety have been reported with high anticancer activity acting by increasing the enzymatic activity of procaspase-3 in cancer cells and therefore inducing apoptosis ...
Synthesis and biological evaluation of new pyrazolone Schiff bases as monoamine oxidase and cholinesterase inhibitors
(Academic Press Inc Elsevier Science, 2019)
In the current work, Schiff base derivatives of antipyrine were synthesized. The chemical characterization of the compounds was confirmed using IR, H-1 NMR, C-13 NMR and mass spectroscopies. The inhibitory potency of ...
Synthesis and antimicrobial activity of new 2-((1-furan-2-yl)ethylidene)hydrazono)-4-phenylthiazol-3(2H)-amine derivatives and their schiff bases with 4-nitrobenzaldehyde
(Taylor & Francis LTD, 2018)
A new series of 2-((1-furan-2-yl)ethylidene)hydrazono)-4-substitutedphenylthiazol-3(2H)-amines (2a-2o) and their Schiff bases (3a-3o) from 4-nitrobenzaldehyde were synthesized. The chemical structures of all the synthesized ...
Design, synthesis and in vitro evaluation of new thiosemicarbazone derivatives as potential anticancer agents
(Marmara University, 2019)
Thiosemicarbazones play a pivotal role as potential therapeutic agents for the management of lung cancer. 4-(4-Cyanophenyl)-1-[(5-arylfuran-2-yl)methylene]thiosemicarbazides (1-10) were obtained via the reaction of ...