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Fighting Against Alzheimer's Disease: Synthesis of New Pyrazoline and Benzothiazole Derivatives as New Acetylcholinesterase and MAO Inhibitors
(Bentham Science Publ LTD, 2018)
Background: Alzheimer's Disease (AD) is a complicated neurodegenerative disorder with a multifaceted pathogenesis. AD, characterized by gradual memory loss, falling in language ability and other cognitive deterioration, ...
Design, Synthesis and Biological Evaluation of Novel N-Pyridyl-Hydrazone Derivatives as Potential Monoamine Oxidase (MAO) Inhibitors
(MDPI, 2018)
A new series of N-pyridyl-hydrazone derivatives was synthesized by using a simple and efficient method. The final compounds obtained were screened for their inhibitory potency against monoamine oxidase (MAO) A and B. The ...
Synthesis and evaluation of bis-thiazole derivatives as new anticancer agents
(Elsevier France-Editions Scientifiques Medicales Elsevier, 2016)
New bis-thiazole derivatives (1-10) were synthesized via the ring closure of 1,1'-(3,3'-dimethoxybipheny1-4,4'-diyl)bis(thiourea) with phenacyl bromides and evaluated for their cytotoxic effects on A549 human lung ...
Synthesis and antimicrobial activities of some novel thiazole compounds
(Walter De Gruyter GMBH, 2018)
Objective: The advent of resistant pathogenic microorganisms against current antimicrobial drugs prompted scientists to investigate novel molecules with new mechanisms. In this paper, some new 2-[2-[4-(ethyl/phenyl)cyclo ...
Synthesis and biological evaluation of some thiazole derivatives as new cholinesterase inhibitors
(Informa Healthcare, 2013)
In the present study, some thiazole derivatives were synthesized via the ring closure reaction of 1-[2-(2-oxobenzo[d] thiazol-3(2H)-yl)acetyl]thiosemicarbazide with various phenacyl bromides. The chemical structures of the ...
Synthesis and antifungal activity of new hydrazide derivatives
(Taylor & Francis LTD, 2013)
In this study, nine new hydrazide derivatives were synthesized. The reaction of 2-[(5,6,7,8-tetrahydronaphthalen-2-yl) oxy]acetohydrazide with various benzaldehydes or acetophenones resulted in N'-substituted-2-[(5,6,7,8 ...
Preparation of Some Thiazolyl Hydrazone Derivatives and Evaluation of Their Antibacterial Activities
(Taylor & Francis LTD, 2009)
The increasing clinical importance of drug-resistant fungal and bacterial pathogens has provided additional urgency to microbiological research and to the development of new antibacterial compounds. For this purpose, new ...
Synthesis and anti-Candida activity of novel 2-hydrazino-1,3-thiazole derivatives
(Pergamon-Elsevier Science LTD, 2013)
Eighteen new hydrazino-1,3-thiazole derivatives were evaluated against 8 strains of multi-resistant Candida spp. Introduction of an indolyl moiety linked to the hydrazone function enhanced the in vitro anti-Candida activity, ...
Synthesis and Antiviral Activity of Some (3,4-Diaryl-3H-Thiazol-2-Ylidene)Pyrimidin-2-Yl Amine Derivatives
(Taylor & Francis LTD, 2011)
Thirteen new (3,4-diaryl-3H-thiazol-2-ylidene) pyrimidin-2-yl amine derivatives were synthesized by reacting 1-aryl-3-pyrimidin-2-yl-thiourea derivatives and phenacyl bromides in absolute ethanol. The solid that separated ...
Synthesis and Evaluation of Thiazole - Pyrimidine Derivatives as New Anticandidal and Cytotoxic Agents
(Springer, 2014)
The aim of this study was to describe the synthesis of four new 2-(3,4-diphenyl-3H-thiazol-2-ylidene)amino-4,6-dimethylpyrimidine derivatives, which were screened for their anticandidal activity and cytotoxicity. The title ...