| dc.contributor.author | Benkli, Kadriye | |
| dc.contributor.author | Tunalı, Yağmur | |
| dc.contributor.author | Cantürk, Zerrin | |
| dc.contributor.author | Artagan, öge | |
| dc.contributor.author | Alanyali, Filiz | |
| dc.date.accessioned | 2019-10-19T14:44:22Z | |
| dc.date.available | 2019-10-19T14:44:22Z | |
| dc.date.issued | 2009 | |
| dc.identifier.issn | 0223-5234 | |
| dc.identifier.uri | https://dx.doi.org/10.1016/j.ejmech.2008.09.017 | |
| dc.identifier.uri | https://hdl.handle.net/11421/13497 | |
| dc.description | WOS: 000266030800030 | en_US |
| dc.description | PubMed ID: 18947906 | en_US |
| dc.description.abstract | In this work, we synthesized and evaluated the cytotoxic effect of [Ru(phi)(3)](2+), on rat C6 glioma cell line. Cell viability was determined by assay with 3-(4-5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT). The mutagenicity of [Ru(phi)(3)](2+) was studied in vitro by using two strains of Salmonella typhimurium with frameshift mutation (TA98) and base-pair substitution mutation (TA100) were used in plate incorporation assay in the absence of metabolic activation. According to the results, the Ru compound is not toxic but mutagenic, and it shows cytotoxic effect towards C6 rat glioma cells in 100 mu M | en_US |
| dc.description.sponsorship | Anadolu University; Commissions of Scientific Research Projects | en_US |
| dc.description.sponsorship | Authors are grateful to Anadolu University, Commissions of Scientific Research Projects for the support of this work. | en_US |
| dc.language.iso | eng | en_US |
| dc.publisher | Elsevier France-Editions Scientifiques Medicales Elsevier | en_US |
| dc.relation.isversionof | 10.1016/j.ejmech.2008.09.017 | en_US |
| dc.rights | info:eu-repo/semantics/closedAccess | en_US |
| dc.subject | 9,10-Phenanthrenequinone Diimine | en_US |
| dc.subject | Ru(Ii) Complex | en_US |
| dc.subject | Mutagenicity | en_US |
| dc.subject | Cytotoxic Effect | en_US |
| dc.subject | Genotoxicity | en_US |
| dc.title | Cytotoxic and genotoxic effects of [Ru(phi)(3)](2+) evaluated by Ames/Salmonella and MTT methods | en_US |
| dc.type | article | en_US |
| dc.relation.journal | European Journal of Medicinal Chemistry | en_US |
| dc.contributor.department | Anadolu Üniversitesi, Eczacılık Fakültesi, Farmasötik Kimya Anabilim Dalı | en_US |
| dc.identifier.volume | 44 | en_US |
| dc.identifier.issue | 6 | en_US |
| dc.identifier.startpage | 2601 | en_US |
| dc.identifier.endpage | 2605 | en_US |
| dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
| dc.contributor.institutionauthor | Benkli, Kadriye | |
| dc.contributor.institutionauthor | Tunalı, Yağmur | |
| dc.contributor.institutionauthor | Cantürk, Zerrin | |
