dc.contributor.author | Kaplancıklı, Zafer Asım | |
dc.contributor.author | Altıntop, Mehlika Dilek | |
dc.contributor.author | Özdemir, Ahmet | |
dc.contributor.author | Turan, Gülhan | |
dc.contributor.author | Göğer, Gamze | |
dc.contributor.author | Demirci, Fatih | |
dc.date.accessioned | 2019-10-19T14:44:28Z | |
dc.date.available | 2019-10-19T14:44:28Z | |
dc.date.issued | 2014 | |
dc.identifier.issn | 1570-1808 | |
dc.identifier.issn | 1875-628X | |
dc.identifier.uri | https://dx.doi.org/10.2174/15701808113109990030 | |
dc.identifier.uri | https://hdl.handle.net/11421/13525 | |
dc.description | WOS: 000331887000012 | en_US |
dc.description.abstract | Nineteen N'-(benzylidene)-2-[(pyrimidin-2-yl)thio]acetohydrazides were obtained via the nucleophilic addition-elimination reaction of 2-[(pyrimidin-2-yl)thio)]acetohydrazide with aromatic aldehydes. The synthesized compounds were tested in vitro against various bacteria by microdilution. Among these compounds, N'-(3-hydroxybenzylidene)-2-[(pyrimidin-2-yl)thio]acetohydrazide (3l) was found to be the most potent derivative (MIC 7.8-15.62 mu g/mL) against Staphylococcus aureus (ATCC 6538), Staphylococcus epidermidis (ATCC 12228), and Escherichia coli (O157:H7-Clinical isolate), respectively. This outcome confirms that m-hydroxyphenyl moiety may have a considerable influence on antibacterial activity of the series tested. In the view of the results of the current work, further research can be carried out on the development of new effective antibacterial agents by the modification of compound 3l. | en_US |
dc.description.sponsorship | Anadolu University Scientific Research Projects Commission [1103S060] | en_US |
dc.description.sponsorship | This study was financially supported by Anadolu University Scientific Research Projects Commission under the grant no: 1103S060. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Bentham Science Publ LTD | en_US |
dc.relation.isversionof | 10.2174/15701808113109990030 | en_US |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.subject | Hydrazone | en_US |
dc.subject | Pyrimidine | en_US |
dc.subject | Antibacterial Activity | en_US |
dc.title | Synthesis and In Vitro Evaluation of Some Hydrazone Derivatives as Potential Antibacterial Agents | en_US |
dc.type | article | en_US |
dc.relation.journal | Letters in Drug Design & Discovery | en_US |
dc.contributor.department | Anadolu Üniversitesi, Eczacılık Fakültesi, Farmasötik Kimya Anabilim Dalı | en_US |
dc.identifier.volume | 11 | en_US |
dc.identifier.issue | 3 | en_US |
dc.identifier.startpage | 355 | en_US |
dc.identifier.endpage | 362 | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.contributor.institutionauthor | Kaplancıklı, Zafer Asım | |
dc.contributor.institutionauthor | Altıntop, Mehlika Dilek | |
dc.contributor.institutionauthor | Özdemir, Ahmet | |
dc.contributor.institutionauthor | Turan, Gülhan | |
dc.contributor.institutionauthor | Demirci, Fatih | |