Advanced Search

Show simple item record

dc.contributor.authorÖzkay, Yusuf
dc.contributor.authorTunalı, Yağmur
dc.contributor.authorKaraca, Hülya
dc.contributor.authorIşıkdağ, İlhan
dc.date.accessioned2019-10-19T14:44:43Z
dc.date.available2019-10-19T14:44:43Z
dc.date.issued2011
dc.identifier.issn0253-6269
dc.identifier.urihttps://dx.doi.org/10.1007/s12272-011-0903-8
dc.identifier.urihttps://hdl.handle.net/11421/13594
dc.descriptionWOS: 000295825600005en_US
dc.descriptionPubMed ID: 21975803en_US
dc.description.abstractDue to antimicrobial importance of benzimidazoles and hydrazones, some benzimidazole-hydrazone compounds were synthesized to screen their antimicrobial activity. Structures of the synthesized compounds were elucidated by (1)H-NMR, IR and ES-MS spectral data and elemental analysis. The synthesized benzimidazole-hydrazones exhibited very weak antibacterial activity. However, antifungal activity of some of the synthesized compounds was very notable against Candida species. The compounds displaying important antifungal activity were screened for their toxicity. Artemia salina 96-well assay was used to determine cytotoxicity of the compounds. Tested compounds exhibited toxicity to different extents (LD(50) = 126.33-368.72 mu g/mL). Nevertheless, determination of 3-14 folds higher LD50 than minimum inhibitory concentration is a significant finding, which demonstrates that the compounds display antifungal activity at non-toxic concentration.en_US
dc.language.isoengen_US
dc.publisherPharmaceutical Soc Koreaen_US
dc.relation.isversionof10.1007/s12272-011-0903-8en_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBenzimidazoleen_US
dc.subjectHydrazoneen_US
dc.subjectAntibacterialen_US
dc.subjectAntifungalen_US
dc.subjectArtemia Salinaen_US
dc.titleAntimicrobial Activity of a New Series of Benzimidazole Derivativesen_US
dc.typearticleen_US
dc.relation.journalArchives of Pharmacal Researchen_US
dc.contributor.departmentAnadolu Üniversitesi, Eczacılık Fakültesi, Farmasötik Kimya Anabilim Dalıen_US
dc.identifier.volume34en_US
dc.identifier.issue9en_US
dc.identifier.startpage1427en_US
dc.identifier.endpage1435en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.contributor.institutionauthorÖzkay, Yusuf
dc.contributor.institutionauthorTunalı, Yağmur


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record