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Synthesis of Some Benzothiazole Based Piperazine-Dithiocarbamate Derivatives and Evaluation of Their Anticancer Activities

dc.contributor.authorTuran, Gülhan
dc.contributor.authorÖzkay, Yusuf
dc.contributor.authorÖzdemir, Ahmet
dc.contributor.authorKaplancıklı, Zafer Asım
dc.contributor.authorAltıntop, Mehlika Dilek
dc.date.accessioned2019-10-19T14:44:50Z
dc.date.available2019-10-19T14:44:50Z
dc.date.issued2011
dc.identifier.issn1570-1808
dc.identifier.urihttps://dx.doi.org/10.2174/157018011797200786
dc.identifier.urihttps://hdl.handle.net/11421/13625
dc.descriptionWOS: 000301480100006en_US
dc.description.abstractSome benzothiazole derivatives bearing piperazine and dithiocarbamate moieties were synthesized in order to investigate their anticancer activity. The structures of the obtained compounds were confirmed by spectral data and elemental analysis. Synthesized compounds were evaluated for their anticancer activity at the National Cancer Institute against a panel of approximately 60 different human tumor cell lines derived from nine neoplastic cancer types. Compound 3f was found to be significantly active against all cancer types in single concentration assay and selected for second step which includes five concentration assays. In the second step, it exhibited very significant activity on melanoma (LOX IMVI) cell line.en_US
dc.language.isoengen_US
dc.publisherBentham Science Publ LTDen_US
dc.relation.isversionof10.2174/157018011797200786en_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAnticancer Activityen_US
dc.subjectBenzothiazoleen_US
dc.subjectDithiocarbamateen_US
dc.subjectLox Imvi Cell Lineen_US
dc.subjectMelonomaen_US
dc.subjectPiperazineen_US
dc.titleSynthesis of Some Benzothiazole Based Piperazine-Dithiocarbamate Derivatives and Evaluation of Their Anticancer Activitiesen_US
dc.typearticleen_US
dc.relation.journalLetters in Drug Design & Discoveryen_US
dc.contributor.departmentAnadolu Üniversitesi, Eczacılık Fakültesi, Farmasötik Kimya Anabilim Dalıen_US
dc.identifier.volume8en_US
dc.identifier.issue9en_US
dc.identifier.startpage830en_US
dc.identifier.endpage837en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.contributor.institutionauthorTuran, Gülhan
dc.contributor.institutionauthorÖzkay, Yusuf
dc.contributor.institutionauthorÖzdemir, Ahmet
dc.contributor.institutionauthorKaplancıklı, Zafer Asım
dc.contributor.institutionauthorAltıntop, Mehlika Dilek


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