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dc.contributor.authorYurttaş, Leyla
dc.contributor.authorTay, Funda
dc.contributor.authorDemirayak, Şeref
dc.date.accessioned2019-10-19T14:45:01Z
dc.date.available2019-10-19T14:45:01Z
dc.date.issued2015
dc.identifier.issn1475-6366
dc.identifier.issn1475-6374
dc.identifier.urihttps://dx.doi.org/10.3109/14756366.2014.945168
dc.identifier.urihttps://hdl.handle.net/11421/13667
dc.descriptionWOS: 000359815200017en_US
dc.descriptionPubMed ID: 25198890en_US
dc.description.abstractTwenty-five new N-[4-(benzothiazole-2-yl)phenyl]acetamide derivatives bearing different heterocyclic ring systems were synthesized using 2-(4-aminophenyl)benzothiazole structure as a pharmacophoric group. Final compounds were screened for their potential antitumor activity in vitro against approximately 60 human tumor cell lines derived from nine neoplastic diseases at National Cancer Institute, USA. 2-(4-Aminophenyl)benzothiazole structure was prepared by the reaction of 4-aminobenzoic acid and 2-aminothiophenol in polyphosphoric acid using microwave irradiation. After acetylation reaction, amide compounds 2a and 2b were obtained, which were then reacted with 2-mercapto(benz)imidazole/benzothiazole/benzoxazole derivatives in acetone with the presence of potassium carbonate to gain final compounds (3-27). Among all tested compounds, compound 10, namely N-[4-(benzothiazole-2-yl)-3-chlorophenyl]-2-[(benzimidazole-2-yl)thio]acetamide, and compound 16, namely N-[4(benzothiazole-2-yl)phenyl]-2-[(1,5-diphenyl-1H-imidazole-2-yl)thio]acetamide, were found to be of considerable anticancer activity against some cancer cell lines.en_US
dc.description.sponsorshipCommission of Scientific Research Projects of Eskisehir Osmangazi University [ESOGU/200819010]; Eskisehir Osmangazi Universityen_US
dc.description.sponsorshipThis work was supported by the Commission of Scientific Research Projects of Eskisehir Osmangazi University (ESOGU/200819010). The authors gratefully acknowledge the financial support by Eskisehir Osmangazi University.en_US
dc.language.isoengen_US
dc.publisherTaylor & Francis LTDen_US
dc.relation.isversionof10.3109/14756366.2014.945168en_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subject2-(4-Aminophenyl)Benzothiazoleen_US
dc.subjectAnticancer Activityen_US
dc.subjectAntitumor Activityen_US
dc.subjectSynthesisen_US
dc.titleSynthesis and antitumor activity evaluation of new 2-(4-aminophenyl)benzothiazole derivatives bearing different heterocyclic ringsen_US
dc.typearticleen_US
dc.relation.journalJournal of Enzyme Inhibition and Medicinal Chemistryen_US
dc.contributor.departmentAnadolu Üniversitesi, Eczacılık Fakültesi, Farmasötik Kimya Anabilim Dalıen_US
dc.identifier.volume30en_US
dc.identifier.issue3en_US
dc.identifier.startpage458en_US
dc.identifier.endpage465en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.contributor.institutionauthorYurttaş, Leyla
dc.contributor.institutionauthorDemirayak, Şeref


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