Synthesis of some 2-[(benzazole-2-yl)thioidiphenylmethylacetamide derivatives and their antimicrobial activity

Abstract

Some 2-[(benzazole-2-yl)thio]diphenylmethylacetamide derivatives were synthesized by reacting 2-chloroacethylaminodiphenylmethane with benzazole-2-thions. The structure elucidation of the compounds was performed by IR, 1H NMR, and MS-FAB spectral data. Antimicrobial activity of the compounds was examined. Some of the compounds have shown similar antifungal activities against C. albicans when compared with ketoconazole. It was also observed that these compounds have moderate antimicrobial activity when compared with chloramphenicole.