Browsing Farmasötik Teknoloji Anabilim Dalı by Title
Now showing items 33-52 of 89
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Formulation and in vitro evaluation of moxifloxacin hydrochloride-loaded polymeric nanoparticles for ocular application
(Colegio de Farmaceuticos de la Provincia de Buenos Aires, 2018)The primary purpose of this study was to extend the time of interaction of the carrier with the negatively charged ocular surface for enhanced penetration in order to improve ocular bioavailability. Moxifloxacin hydrochloride ... -
Formulation and in vitro-in vivo evaluation of piribedil solid lipid micro- and nanoparticles
(Taylor & Francis LTD, 2001)Modification of the dissolution rate and, thus, the enhancement of the bioavailability of a dopaminergic drug, piribedil, which has a low aqueous solubility and short elimination half-life have been the aim in this study. ... -
Formulation and in-vivo evaluation of a cosmetic multiple emulsion containing vitamin C and wheat protein
(University Karachi, 2008)The purpose of the study was to see the effect of two antiaging agents in one stable multiple emulsion prepared using natural oil. Vitamin C, which is a very unstable ingredient and is decomposed in the presence of oxygen, ... -
Gamma-aminobutyric acid loaded halloysite nanotubes and in vitro-in vivo evaluation for brain delivery
(Elsevier Science BV, 2015)Gamma-aminobutyric acid (GABA) is a key neurotransmitter where it usually inhibits impulse transmission. GABA release blockage or postsynaptic reaction were determined to provoke epileptic convulsions. The aim of the present ... -
Improvement in the dissolution properties of theophylline with ß-cyclodextrin
(1994)An improvement in the dissolution of theophylline with ß-cyclodextrin was achieved by subjecting them to co-grinding and freeze-drying methods. The products obtained were examined by the phase solubility methad, differential ... -
In vitro evaluation of sustained released matrix tablet formulations of clarithromycin
(Osterreichische Apotheker-Verlagsgesellschaft m.b.H., 2005)Sustained release matrix tablets of clarithromycin were prepared using different polymers as Hydroxypropyl methylcellulose (HPMC), Carbopol 934 and Eudragit RL/PO by direct compression technique. For the quality control ... -
In vitro/in vivo evaluation of gamma-aminobutyric acid-loaded N,N-dimethylacrylamide-based pegylated polymeric nanoparticles for brain delivery to treat epilepsy
(Taylor & Francis LTD, 2016)Objectives of this study were the delivery of gamma aminobutyric acid (GABA) into the brain by means of developing brain targeted, nanosized, non-toxic and biocompatible polymeric nanoparticles, and investigating their ... -
Inclusion complexes of fluconazole with beta-cyclodextrin: physicochemical characterization and in vitro evaluation of its formulation
(Springer, 2011)Fluconazole (FZ) is a triazole antifungal drug administered orally or intravenously. It is employed for the treatment of mycotic infections. However, the efficacy of FZ is limited with its poor aqueous solubility and low ... -
Inclusion complexes of ketoconazole with beta-cyclodextrin: physicochemical characterization and in vitro dissolution behaviour of its vaginal suppositories
(Springer, 2011)Ketoconazole (KZ) is an imidazole antifungal agent which is administered topically and also orally. KZ is practically insoluble in water. Vaginal candidiasis is a common condition and up to 75% of all women have at least ... -
Influence of glyceryl behenate, tripalmitin and stearic acid on the properties of clarithromycin incorporated solid lipid nanoparticles (SLNs): Formulation, characterization, antibacterial activity and cytotoxicity
(Editions de Sante, 2019)Clarithromycin (CLR) is a macrolide derivative which is included in BCS class 2 with low oral bioavailability. Solid lipid nanoparticles (SLNs) have been studied by many researchers for drug application and are very popular ... -
Investigation of certain varieties of carbopol in ketorolac tromethamine hydrophilic matrix tablet formulations and evaluation of the kinetics of its in vitro release
(Osterreichische Apotheker-Verlagsgesellschaft m.b.H., 2002)Matrix tablets of ketorolac tromethamine (KT) were prepared by direct compression technique and Carbopol 934, 940 and 1342 have been used as polymers in different concentrations (5-15%). For the quality control of tablets; ... -
Microencapsulation of ketorolac tromethamine by means of a coacervation phase separation technique induced by the addition of non-solvent
(Taylor & Francis LTD, 1998)Ketorolac tromethamine (KT) is a non-steroidal drug with potent analgesic and anti-inflammatory activity and is absorbed rapidly (T-max (1.0h) with an efficiency >87% following oral and intramuscular administration. The ... -
Multiple emulsions
(1993)The purpose of this review is to update the information on multiple emulsions known to be promising delivery systems for both pharmaceuticals and cosmetic materials. The possibility of encapsulating active substances within ... -
New approach to hypertension treatment: Carvediol-loaded PLGA nanoparticles, preparation, in vitro characterization and gastrointestinal stability
(Colegio de Farmaceuticos de la Provincia de Buenos Aires, 2018)Carvedilol (CVL) has advantages over the first generation of ß-blockers in patients with heart failure due to its properties of reducing cardiovascular morbidity and mortality. On the other hand, CVL has a short half-life ... -
New Approach to Hypertension Treatment: Carvediol-Loaded PLGA Nanoparticles, Preparation, In Vitro Characterization and Gastrointestinal Stability
(Colegio Farmaceuticos Provincia De Buenos Aires, 2018)Carvedilol (CVL) has advantages over the first generation of beta-blockers in patients with heart failure due to its properties of reducing cardiovascular morbidity and mortality. On the other hand, CVL has a short half-life ... -
The next generation of skin antiaging dermacosmetic products [Cilt yaşlanmasi{dotless} karşi{dotless}ti{dotless} dermakozmetik ürünlerde gelecek jenerasyon]
(Turkiye Klinikleri, 2008)Among the visible changes frequently seen in aged skin are roughness in skin surface, widening of pores, sagging with wrinkling, excess skin on eyelids, downward mouth, double chin, color changes such as paling, darkening ... -
Ocular application of chitosan
(Taylor & Francis LTD, 2012)Introduction: A major problem in ocular therapeutics with classical formulations is the maintenance of an effective drug concentration at the site of action for a long period of time. Enhancement of ocular bioavailability ... -
Ocular Application of Dirithromycin Incorporated Polymeric Nanoparticles: an In Vitro Evaluation
(Turkish Pharmacists Assoc, 2017)Objectives: Ocular drug delivery is a difficult challenge especially with topical intillation which results in rapid drainage and non-productive drug absorption. For the improvement of the pre-corneal retention time and ... -
Olopatadine hydrochloride loaded Kollidon (R) SR nanoparticles for ocular delivery: Nanosuspension formulation and in vitro-in vivo evaluation
(Elsevier Science BV, 2019)Introduction: Allergic eye diseases includes a spectrum of diseases, with each state being characterized by a complicated immunopathology. In the present study, polymeric Kollidon (R) SR nanoparticles loaded with olopatadine ...