Yayın tarihi için Farmasötik Teknoloji Anabilim Dalı listeleme
Toplam kayıt 89, listelenen: 41-60
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Ocular application of chitosan
(Taylor & Francis LTD, 2012)Introduction: A major problem in ocular therapeutics with classical formulations is the maintenance of an effective drug concentration at the site of action for a long period of time. Enhancement of ocular bioavailability ... -
Preparation and characterization of polymeric and lipid nanoparticles of pilocarpine HCl for ocular application
(Informa Healthcare, 2013)Pilocarpine is used topically in the treatment of glaucoma. Various studies were performed to improve the bioavailability and prolong the residence time of drugs in ocular drug delivery. Drug loaded polymeric and lipid ... -
Determination of micelle formation of ketorolac tromethamine in aqueous media by acoustic measurements
(Elsevier Science BV, 2013)Density and speed of sound of ketorolac tromethamine in aqueous solutions have been measured as a function of concentration at atmospheric pressure and in the temperature range from 293.15 to 313.15 K. Apparent molar ... -
Chitosan nanoparticles for ocular delivery of cyclosporine A
(Taylor & Francis LTD, 2014)In the present study, cyclosporine A (CsA) was successfully incorporated into cationic chitosan nanoparticles by spray-drying method aiming ocular application. Physicochemical characterisation of particles was performed ... -
Preparation and characterization of methotrexate-loaded microcapsules
(Taylor & Francis LTD, 2014)Methotrexate (MTX) has toxic effect to healthy tissues. Microencapsulation coats particles with a functional coat to optimize storage stability and to modulate release. In the present study, a new MTX encapsulated microcapsules ... -
Ornidazole Incorporated Chitosan Nanoparticles for Ocular Application
(Colegio Farmaceuticos Provincia De Buenos Aires, 2015)Considering the low ocular bioavailability of conventional formulations used for ocular bacterial infection treatment, there is a need for developing efficient modern drug delivery systems. Main attempt in this study was ... -
Enhanced bioavailability of cinnarizine using solid dispersion: In vitro and in vivo evaluation
(Bentham Science Publishers B.V., 2015)The aim of this study was to modify the release and thus enhance the bioavailability of acalcium antagonist cinnarizine whose aqueouse solubility is low and half-life is short. For this purpose, solid dispersion system was ... -
Studies on Polymeric and Lipid Nanoparticles of Ketoconazole for Ocular Administration
(Colegio Farmaceuticos Provincia De Buenos Aires, 2015)The fungistatic molecule ketoconazole was incorporated into polymeric (Eudragit (R) RS 100) and solid lipid (Gelucire (R) 44/14) nanoparticles by quasi-emulsion solvent evaporation technique aiming ocular application. ... -
Gamma-aminobutyric acid loaded halloysite nanotubes and in vitro-in vivo evaluation for brain delivery
(Elsevier Science BV, 2015)Gamma-aminobutyric acid (GABA) is a key neurotransmitter where it usually inhibits impulse transmission. GABA release blockage or postsynaptic reaction were determined to provoke epileptic convulsions. The aim of the present ... -
Ornidazole incorporated chitosan nanoparticles for ocular application
(Colegio de Farmaceuticos de la Provincia de Buenos Aires, 2015)Considering the low ocular bioavailability of conventional formulations used for ocular bacterial infection treatment, there is a need for developing efficient modern drug delivery systems. Main attempt in this study was ... -
Characterization of Solid Lipid Nanoparticles Containing Caffeic Acid and Determination of its Effects on MCF-7 Cells
(Bentham Science Publ LTD, 2015)Many anticancer drugs that are currently used in cancer treatment are natural products or their analogues by structural modification. Caffeic acid (3, 4-dihydroxycinnamic acid; CA) is classified as hydroxycinnamic acid and ... -
The aggregation behavior of trimetazidine hydrochloride in aqueous solutions at different temperatures
(Elsevier Science BV, 2015)The aggregation behavior of trimetazidine hydrochloride (TMZ HCl) in aqueous solutions has been investigated by electrical conductivity, ultrasonic speed and density measurements in the temperature ranges from 298.15 to ... -
Vitamin B-12-loaded solid lipid nanoparticles as a drug carrier in cancer therapy
(Informa Healthcare, 2015)Nanostructure-mediated drug delivery, a key technology for the realization of nanomedicine, has the potential to improve drug bioavailability, ameliorate release deviation of drug molecules and enable precision drug ... -
Chitosan gel formulations containing egg yolk oil and epidermal growth factor for dermal burn treatment
(Govi-Verlag Pharmazeutischer Verlag GMBH, 2015)In the present study chitosan based gel formulations containing Egg Yolk Oil (EYO) and Epidermal Growth Factor (EGF) were formulated successfully aiming at enhanced topical treatment of dermal burns the combination of ... -
Studies on rosuvastatin calcium incorporated chitosan salt nanoparticles
(Colegio de Farmaceuticos de la Provincia de Buenos Aires, 2016)Cardiovascular diseases are the leading causes of death worldwide and rosuvastatin calcium (RCa) is one of the most effective drugs used for the prevention of coronary heart diseases. Considering low aqueous solubility ... -
In vitro/in vivo evaluation of gamma-aminobutyric acid-loaded N,N-dimethylacrylamide-based pegylated polymeric nanoparticles for brain delivery to treat epilepsy
(Taylor & Francis LTD, 2016)Objectives of this study were the delivery of gamma aminobutyric acid (GABA) into the brain by means of developing brain targeted, nanosized, non-toxic and biocompatible polymeric nanoparticles, and investigating their ... -
The effect of solid lipid nanoparticles on tamoxifen-resistant breast cancer cells
(Innovare Academics Sciences Pvt. Ltd, 2016)To overcome the acquired Tamoxifen (Tam) resistance in Tam-resistant breast cancer cells without damaging normal cells, we have examined the therapeutic efficacy of Tam-loaded solid lipid nanoparticles (SLNs). Tam-loaded ... -
Voriconazole Incorporated Polymeric Nanoparticles for Ocular Application
(Colegio Farmaceuticos Provincia De Buenos Aires, 2017)Limitations of topical ocular application lead to unsufficient treatment in severe ocular disorders, therefore the researchers focused on novel drug delivery systems for the achievement of enhanced ocular bioavailability. ... -
Dexketoprofen trometamol-loaded kollidon® SR and eudragit® RS 100 polymeric nanoparticles: Formulation and in vitro-in vivo evaluation
(Colegio de Farmaceuticos de la Provincia de Buenos Aires, 2017)Development and in vivo/in vitro evaluation of dexketoprofen trometamol (DT)-loaded nanosized, controlled release drug delivery system was aimed in this study.. DT-loaded Kollidon® SR (KSR) and Eudragit® RS 100 (ERS) ...