Yazar "Genç, Lütfi" için Farmasötik Teknoloji Anabilim Dalı listeleme
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The aggregation behavior of trimetazidine hydrochloride in aqueous solutions at different temperatures
Genç, Lütfi (Elsevier Science BV, 2015)The aggregation behavior of trimetazidine hydrochloride (TMZ HCl) in aqueous solutions has been investigated by electrical conductivity, ultrasonic speed and density measurements in the temperature ranges from 298.15 to ... -
Characterization of Solid Lipid Nanoparticles Containing Caffeic Acid and Determination of its Effects on MCF-7 Cells
Dikmen, Gökhan; Güney, Gamze; Genç, Lütfi (Bentham Science Publ LTD, 2015)Many anticancer drugs that are currently used in cancer treatment are natural products or their analogues by structural modification. Caffeic acid (3, 4-dihydroxycinnamic acid; CA) is classified as hydroxycinnamic acid and ... -
Determination of micelle formation of ketorolac tromethamine in aqueous media by acoustic measurements
Savaroğlu, Gökhan; Genç, Lütfi (Elsevier Science BV, 2013)Density and speed of sound of ketorolac tromethamine in aqueous solutions have been measured as a function of concentration at atmospheric pressure and in the temperature range from 293.15 to 313.15 K. Apparent molar ... -
The effect of solid lipid nanoparticles on tamoxifen-resistant breast cancer cells
Eskiler, G. Güney; Cecener, G.; Dikmen, G.; Genç, Lütfi; Egeli, U. (Innovare Academics Sciences Pvt. Ltd, 2016)To overcome the acquired Tamoxifen (Tam) resistance in Tam-resistant breast cancer cells without damaging normal cells, we have examined the therapeutic efficacy of Tam-loaded solid lipid nanoparticles (SLNs). Tam-loaded ... -
Film-coated enteric tablet formulation of ketorolac tromethamine
Genç, Lütfi; Güler, Erden; Hegazy, Nahed (Informa Healthcare, 1997)A great majority of polymers used for pharmaceutical film-coating purposes have been derivatives of cellulose or methacrylate copolymers (Eudragit series) in most recent studies. The type and frequency of the ester ... -
In vitro evaluation of sustained released matrix tablet formulations of clarithromycin
Genç, Lütfi; Kıran, A. M. (Osterreichische Apotheker-Verlagsgesellschaft m.b.H., 2005)Sustained release matrix tablets of clarithromycin were prepared using different polymers as Hydroxypropyl methylcellulose (HPMC), Carbopol 934 and Eudragit RL/PO by direct compression technique. For the quality control ... -
Inclusion complexes of fluconazole with beta-cyclodextrin: physicochemical characterization and in vitro evaluation of its formulation
Yurtdaş Kırımlıoğlu, Gülsel; Demirel, Müzeyyen; Genç, Lütfi (Springer, 2011)Fluconazole (FZ) is a triazole antifungal drug administered orally or intravenously. It is employed for the treatment of mycotic infections. However, the efficacy of FZ is limited with its poor aqueous solubility and low ... -
Inclusion complexes of ketoconazole with beta-cyclodextrin: physicochemical characterization and in vitro dissolution behaviour of its vaginal suppositories
Demirel, Müzeyyen; Yurtdaş Kırımlıoğlu, Gülsel; Genç, Lütfi (Springer, 2011)Ketoconazole (KZ) is an imidazole antifungal agent which is administered topically and also orally. KZ is practically insoluble in water. Vaginal candidiasis is a common condition and up to 75% of all women have at least ... -
Investigation of certain varieties of carbopol in ketorolac tromethamine hydrophilic matrix tablet formulations and evaluation of the kinetics of its in vitro release
Genç, Lütfi; Hegazy, N.; Arıca, B. (Osterreichische Apotheker-Verlagsgesellschaft m.b.H., 2002)Matrix tablets of ketorolac tromethamine (KT) were prepared by direct compression technique and Carbopol 934, 940 and 1342 have been used as polymers in different concentrations (5-15%). For the quality control of tablets; ... -
Microencapsulation of ketorolac tromethamine by means of a coacervation phase separation technique induced by the addition of non-solvent
Genç, Lütfi; Demirel, Müzeyyen; Güler, E; Hegazy, N (Taylor & Francis LTD, 1998)Ketorolac tromethamine (KT) is a non-steroidal drug with potent analgesic and anti-inflammatory activity and is absorbed rapidly (T-max (1.0h) with an efficiency >87% following oral and intramuscular administration. The ... -
Preparation and characterization of methotrexate-loaded microcapsules
Genç, Lütfi; Büyüktiryaki, Sibel (Taylor & Francis LTD, 2014)Methotrexate (MTX) has toxic effect to healthy tissues. Microencapsulation coats particles with a functional coat to optimize storage stability and to modulate release. In the present study, a new MTX encapsulated microcapsules ... -
Preparation and in vitro evaluation of controlled release hydrophilic matrix tablets of ketorolac tromethamine using factorial design
Genç, Lütfi; Jalvand, Esmaeil (Informa Healthcare, 2008)Controlled release matrix tablets of ketorolac tromethamine (KT) were prepared by direct compression technique using cellulose derivatives as hydroxypropylmethyl cellulose (HPMC), hydroxyethyl cellulose (HEC), and carboxymethyl ... -
Preparation of prolonged release clarithromycin microparticles for oral use and their in vitro evaluation
Genç, Lütfi; Demirel, Müzeyyen; Yazan, Yasemin (Pharmaceutical Soc Korea, 2006)Prolonged release microparticles of clarithromycin (CL) were prepared using Eudragit RL 100 and RS 100 by spray-drying and casting-drying techniques. For the characterization of those microparticles, preparation yield, ... -
Studies on furazolidone suspension formulations
Genç, Lütfi; Güler, Erden (1992)[No abstract available] -
Studies on Polymeric and Lipid Nanoparticles of Ketoconazole for Ocular Administration
Demirel, Müzeyyen; Genç, Lütfi (Colegio Farmaceuticos Provincia De Buenos Aires, 2015)The fungistatic molecule ketoconazole was incorporated into polymeric (Eudragit (R) RS 100) and solid lipid (Gelucire (R) 44/14) nanoparticles by quasi-emulsion solvent evaporation technique aiming ocular application. ... -
Studies on trifluorothymidine ophthalmic formulations and their stability
Genç, Lütfi; Güler, Erden; Kurtcebe, D. (1994)[No abstract available] -
Studies on vaginal bioadhesive tablets of acyclovir
Genç, Lütfi; Oğuzlar, C; Güler, E (Govi-Verlag GMBH, 2000)Bioadhesive vaginal tablets were prepared using poly(acrylic acid) (PAA); Methylcellulose (MC), carboxymethyl cellulose (CMC), hydroxypropyl cellulose (HPC) and hydroxypropylmethyl cellulose (HPMC) as bioadhesive polymers ... -
Sustained release wax matrix formulations of ketorolac tromethamine with Compritol 888 ATO and HD 5 ATO
Genç, Lütfi; Hegazy, N. (2000)Sustained release wax matrix tablets of ketorolac tromethamine (KT) were prepared with different concentrations of Compritol 888 ATO (Glyceryl behenate) and HD 5 ATO (Glyceryl and Polyethylene glycol behenate). Tablet ... -
Vitamin B-12-loaded solid lipid nanoparticles as a drug carrier in cancer therapy
Genç, Lütfi; Kutlu, Hatice Mehtap; Güney, Gamze (Informa Healthcare, 2015)Nanostructure-mediated drug delivery, a key technology for the realization of nanomedicine, has the potential to improve drug bioavailability, ameliorate release deviation of drug molecules and enable precision drug ...