Browsing Farmasötik Toksikoloji Anabilim Dalı by Issue Date
Now showing items 1-20 of 46
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Studies on controlled release dimenhydrinate from matrix tablet formulations
(1999)In this study, controlled release dosage forms of dimenhydrinate were prepared with different polymers as MC, HEC, Carbopol 934, Eudragit RLPM and Eudragit NE 30 D at different concentrations (2.5-10%). Direct compression ... -
Cardioprotection with resveratrol pretreatment: improved beneficial effects over standard treatment in rat hearts after global ischemia
(Taylor & Francis LTD, 2004)Objective-The major objective of the present study is to evaluate the potential role of resveratrol (RVT), a natural antioxidant found in grapes and red wine, in protecting the myocardium from the deleterious effects of ... -
Effects of sildenafil citrate administration on cardiovascular system of subchronic fluoxetine HCI treated male rats
(2005)Amaç: Sildenafil sitrat fluoksetin HCl tedavisine bağlı olarak gelişen erektil disfonksiyon tedavisinde sıklıkla kullanılan bir ilaçtır. Fluoksetin HCl sildenafil metabolizmasında rol oynayan P450 CYP3A4 ve CYP2C enzimlerini ... -
Effects of sildenafil citrate administration on cardiovascular system of subchronic fluoxetine HCl treated male rats
(Turkiye Klinikleri, 2005)Objective: Sildenafil citrate is a commonly used drug for the treatment of erectile dysfunction accompanied with fluoxetine HCl treatment. Fluoxitine HCl inhibits the cytochrome P450 CYP3A4 and CYP2C enzymes which are the ... -
Ketamine: A popular recreational drug: Review [Ketamin: Popüler bir keyif verici i·laç]
(Turkiye Klinikleri, 2005)Ketamine is an anaesthetic agent, characterised by rapid onset of action with profound analgesic and moderate hypnotic properties. Today, the pharmacological use of ketamine is limited. However, because of its hallucinogenic ... -
Composition of some herbal slimming tea preparations marketed in Turkey and their possible adverse effects [Türkiye'de satilan bazi bitkisel zayiflama çaylarinin i·çerikleri ve bu çaylarin kullanimina bagli ortaya çikabilecek i·stenmeyen etkiler]
(Turkiye Klinikleri, 2006)Objective: The interest in herbal products has been increasing in recent years. Herbal weight-loss products are widely used because they are believed to be harmless, especially among women who want to lose weight. However, ... -
Estrogenic effects of lycopene and beta-carotene on ER(+) HeLa and LNcaP cancer cells
(Blackwell Publishing, 2006)… -
Validated reversed phase HPLC method for the analysis of the food additive, sodium benzoate, in soft drinks and jams
(Taylor & Francis Inc, 2007)A rapid, simple, and sensitive method is described for the determination of the food preservative sodium benzoate in soft drinks, various jams, and ketchup. The method utilizes high performance liquid chromatography followed ... -
Evaluation of cardiotoxic effect potential of ciprofloxacin and ofloxacin in juvenile rats using serum biochemical parameters
(Elsevier Ireland LTD, 2007)… -
Consideration of anticarcinogenic activity of lycopene on ER(+) HeLa and LNCaP cancer cells
(Elsevier Ireland LTD, 2007)… -
Determination of hesperidin and neohesperidin in fruit juices using high performance liquid chromatographic (HPLC) method
(Elsevier Ireland LTD, 2007)… -
Oxidative stress-mediated myrocardiotoxicity of ciprofloxacin and ofloxacin in juvenile rats
(Taylor & Francis Inc, 2009)In this study, evaluation of the myocardiotoxic effect potential of ciprofloxacin and ofloxacin in juvenile rats and the role of oxidative stress in heart toxicity was conducted. Doses (25 and 50 mg/kg) of each drug were ... -
The effect of combination therapy on the plasma concentrations of traditional antiepileptics: A retrospective study
(SAGE Publications LTD, 2012)The present study aimed at determining the differences in plasma concentrations of traditional antiepileptics such as phenytoin, carbamazepine, and valproic acid in patients receiving monotherapy and combination therapy. ... -
Effects of Everolimus in Combination with Sildenafil in Monocrotaline-induced Pulmonary Hypertension in Rats
(Humana Press Inc, 2012)In our study, we investigated the efficacy of everolimus in combination with sildenafil on hemodynamic and morphological parameters in rats with monocrotaline-induced pulmonary hypertension (PH). Right ventricular pressure ... -
The effects of gender difference on monocrotaline-induced pulmonary hypertension in rats
(SAGE Publications LTD, 2013)The present study aimed to compare the effect of gender difference on hemodynamic consequences in the development of monocrotaline (MCT)-induced pulmonary hypertension in rat. The effect of antioxidant enzyme systems on ... -
Acute drug poisonings in Eskisehir, Turkey: A retrospective study
(2013)Bu çalışmada ESOGU Tıp Fakültesi Hastanesi Yetişkin Acil Servisine Ocak 2003 - Aralık 2009 yılları arasında başvuran akut ilaç zehirlenme olgularının retrospektif olarak değerlendirilmesi amaçlanmaktadır. Bu amaçla olgulara ... -
Acute drug poisonings in Eskisehir, Turkey: A retrospective study [Eskişehirde akut i·laç zehirlenmeleri: Retrospektif bir çahşma]
(2013)The aim of this study was to characterize acute drug-poisoning cases admitted to the Adult Emergency Service of ESOGU Medicine Faculty Hospital, Turkey. All acute drug-poisoning cases admitted to the emergency service from ... -
Acute and Subchronic Toxic Effects of the Fruits of Physalis peruviana L.
(Hindawi Publishing Corporation, 2013)The fruit of Physalis peruviana L. (PPL) has been traditionally used as antispasmodic, diuretic, antiseptic, sedative, and analgesic all over the world. We aimed to perform qualitative content analysis of the fruits of PPL ... -
Assessment of the Endothelial Functions in Monocrotaline-induced Pulmonary Hypertension
(Taylor & Francis Inc, 2013)Pulmonary hypertension (PH) is a life-threatening disease that causes endothelial dysfunction in the pulmonary vascular bed. Systemic endothelial dysfunction has also been reported in PH. This study compared the systemic ... -
Is N-acetyl cysteine protective against monocrotaline-induced toxicity?
(Taylor & Francis Inc, 2013)Monocrotaline (MCT) is a pyrrolizidine alkaloid which induces cardio-pulmonary toxicity and hepatotoxicity in animals and humans. MCT is frequently ingested because of food grain contamination accidentally or in the form ...
