Yazar "Anadolu Üniversitesi, Eczacılık Fakültesi, Farmasötik Toksikoloji Anabilim Dalı" için Makale Koleksiyonu listeleme
-
Acute and Subchronic Toxic Effects of the Fruits of Physalis peruviana L.
Perk, Başak Özlem; Ilgın, Sinem; Atlı Eklioğlu, Özlem; Duymuş, Hale Gamze; Sırmagül, Başar (Hindawi Publishing Corporation, 2013)The fruit of Physalis peruviana L. (PPL) has been traditionally used as antispasmodic, diuretic, antiseptic, sedative, and analgesic all over the world. We aimed to perform qualitative content analysis of the fruits of PPL ... -
Acute drug poisonings in Eskisehir, Turkey: A retrospective study
Ergün, Bülent; Çevik, Alper Arif; Ilgın, Sinem; Atlı Eklioğlu, Özlem; Saraçoğlu, Ahmet; Acar, Nurdan (2013)Bu çalışmada ESOGU Tıp Fakültesi Hastanesi Yetişkin Acil Servisine Ocak 2003 - Aralık 2009 yılları arasında başvuran akut ilaç zehirlenme olgularının retrospektif olarak değerlendirilmesi amaçlanmaktadır. Bu amaçla olgulara ... -
Acute drug poisonings in Eskisehir, Turkey: A retrospective study [Eskişehirde akut i·laç zehirlenmeleri: Retrospektif bir çahşma]
Ergün, Bülent; Çevik, Alper Arif; Ilgın, Sinem; Atlı Eklioğlu, Özlem; Saraçoğlu, Ahmet; Acar, N.; Uzuncakara, D. (2013)The aim of this study was to characterize acute drug-poisoning cases admitted to the Adult Emergency Service of ESOGU Medicine Faculty Hospital, Turkey. All acute drug-poisoning cases admitted to the emergency service from ... -
Assessment of the Endothelial Functions in Monocrotaline-induced Pulmonary Hypertension
Sırmagül, Başar; Ilgın, Sinem; Atlı Eklioğlu, Özlem; Usanmaz, Suzan Emel; Demirel-Yılmaz, Emine (Taylor & Francis Inc, 2013)Pulmonary hypertension (PH) is a life-threatening disease that causes endothelial dysfunction in the pulmonary vascular bed. Systemic endothelial dysfunction has also been reported in PH. This study compared the systemic ... -
Assessment of trazodone-induced cardiotoxicity after repeated doses in rats
Atlı Eklioğlu, Özlem; Kılıç, Volkan; Baysal, Merve; Aydoğan Kılıç, Gözde; Gormus, G.; Ucarcan, S.; Ilgın, Sinem (SAGE Publications LTD, 2019)Trazodone (TRZ) is an antidepressant drug commonly used in the treatment of depression, anxiety, and insomnia. Although some studies demonstrated the adverse effects of TRZ related to cardiovascular system, the conflicting ... -
Biotransformation of abietic acid by fungi and biological evaluation of its metabolites
Özşen, Özge; Kıran, İsmail; Dağ, İlknur; Atlı Eklioğlu, Özlem; Çiftçi, Gülsen Akalın; Demirci, Fatih (Elsevier Sci LTD, 2017)Biotransformation of abietic acid was carried out initially using 28 different microbial strains. Among the evaluated, Mucor ramannianus produced a known metabolite namely 2 alpha-hydroxy-dehydroabietic acid whereas ... -
Cardioprotection with resveratrol pretreatment: improved beneficial effects over standard treatment in rat hearts after global ischemia
Dernek, S; İkizler, M; Erkasap, Nilüfer; Ergün, B; Köken, T; Yılmaz, K; Kural, T (Taylor & Francis LTD, 2004)Objective-The major objective of the present study is to evaluate the potential role of resveratrol (RVT), a natural antioxidant found in grapes and red wine, in protecting the myocardium from the deleterious effects of ... -
Ciprofloxacin-induced neurotoxicity: evaluation of possible underlying mechanisms
Ilgın, Sinem; Can, Özgür Devrim; Atlı Eklioğlu, Özlem; Ucel, Umut İrfan; Şener, Erol; Güven, İlkay (Taylor & Francis LTD, 2015)Ciprofloxacin (CPX) is a fluoroquinolone antibiotic used for treating respiratory, urinary tract, gastrointestinal and abdominal infections. There are only a limited number of studies related to neurological adverse effects ... -
Citalopram Induces Reproductive Toxicity in Male Rats
Ilgın, Sinem; Aydoğan-Kılıc, G.; Baysal, Merve; Kılıç, Volkan; Korkut, Büşra; Uçarcan, Şeyda; Atlı Eklioğlu, Özlem (Wiley, 2017)Background: Citalopram hydrobromide (CTL) has been shown to cause sexual dysfunction; however, its reproductive toxicity potential has not been sufficiently elucidated in men. Therefore, we aimed to clarify the toxic effects ... -
Design and Synthesis of New Benzothiazole Compounds as Selective hMAO-B Inhibitors
Ilgın, Sinem; Osmaniye, Derya; Levent, Serkan; Sağlık, Begüm Nurpelin; Çevik, Ulviye Acar; Kaya Çavuşoğlu, Betül; Kaplancıklı, Zafer Asım (MDPI AG, 2017)In the current work a new class of novel benzothiazole-hydrazone derivatives was designed and synthesized as hMAO-B inhibitors. Structures of the obtained compounds (3a-3j) were characterized by IR, 1H-NMR, 13C-NMR, and ... -
Determination of Phenolic Compounds of Stachys Rupestris Montbret Et Aucher Ex Bentham By Lc-Ms/Ms and Its Biological Activities
Ergün, Bülent; Göğer, Fatih; Köse, Yavuz Bülent; İşcan, Gökalp (Parlar Scientific Publications (PSP), 2018)One of the largest genus of Lamiaceae, Stachys, extended from south western part of Asia to America, represented in Turkey with % 48 endemism rate. In this presented study LC-ESI-MS/MS properties, anticandidal, antioxidant ... -
The effect of combination therapy on the plasma concentrations of traditional antiepileptics: A retrospective study
Sırmagül, B.; Atlı Eklioğlu, Özlem; Ilgın, Sinem (SAGE Publications LTD, 2012)The present study aimed at determining the differences in plasma concentrations of traditional antiepileptics such as phenytoin, carbamazepine, and valproic acid in patients receiving monotherapy and combination therapy. ... -
Effects of Everolimus in Combination with Sildenafil in Monocrotaline-induced Pulmonary Hypertension in Rats
Ilgın, Sinem; Burukoğlu, Dilek; Atlı Eklioğlu, Özlem; Sırmagül, Başar (Humana Press Inc, 2012)In our study, we investigated the efficacy of everolimus in combination with sildenafil on hemodynamic and morphological parameters in rats with monocrotaline-induced pulmonary hypertension (PH). Right ventricular pressure ... -
The effects of gender difference on monocrotaline-induced pulmonary hypertension in rats
Bal, E.; Ilgın, Sinem; Atlı Eklioğlu, Özlem; Ergün, Bülent; Sırmagül, Başar (SAGE Publications LTD, 2013)The present study aimed to compare the effect of gender difference on hemodynamic consequences in the development of monocrotaline (MCT)-induced pulmonary hypertension in rat. The effect of antioxidant enzyme systems on ... -
Effects of sildenafil citrate administration on cardiovascular system of subchronic fluoxetine HCI treated male rats
Saraçoğlu, Ahmet; Ergün, Bülent; Uzuner, Kubilay (2005)Amaç: Sildenafil sitrat fluoksetin HCl tedavisine bağlı olarak gelişen erektil disfonksiyon tedavisinde sıklıkla kullanılan bir ilaçtır. Fluoksetin HCl sildenafil metabolizmasında rol oynayan P450 CYP3A4 ve CYP2C enzimlerini ... -
Effects of sildenafil citrate administration on cardiovascular system of subchronic fluoxetine HCl treated male rats
Saraçoğlu, Ahmet; Ergün, Bülent; Uzuner, K.; Aydın, Y. (Turkiye Klinikleri, 2005)Objective: Sildenafil citrate is a commonly used drug for the treatment of erectile dysfunction accompanied with fluoxetine HCl treatment. Fluoxitine HCl inhibits the cytochrome P450 CYP3A4 and CYP2C enzymes which are the ... -
Evaluation of antimicrobial, Cytotoxic and genotoxic activities of Ganoderma lucidum (Reishi mushroom)
Ergün, Bülent (University Karachi, 2017)Ganoderma lucidum (GL) is a mushroom used as a traditional remedy for the treatment of various infections since ancient times. This study, was aimed to investigate antimicrobial activity potential of GL against Staphylococcus ... -
Evaluation of azithromycin induced cardiotoxicity in rats
Atlı Eklioğlu, Özlem; Ilgın, Sinem; Altuntaş, Hakan; Burukoğlu, Dilek (E-Century Publishing Corp, 2015)Although there are possible cardiovascular adverse effects associated with the azithromycin treatment according to some case reports and cohort studies, there is no experimental study evaluating cardiotoxicity in repeated ... -
Evaluation of the reproductive toxicity of naproxen sodium and meloxicam in male rats
Uzun, B.; Atlı Eklioğlu, Özlem; Perk, B. O.; Burukoğlu, D.; Ilgın, Sinem (SAGE Publications LTD, 2015)Nonsteroidal anti-inflammatory drugs that are cyclooxygenase (COX) enzyme inhibitors have generally been used in short-term pain management and also to treat inflammation chronically. It is known that COX enzyme and ... -
Evidence for cardiotoxicity associated with sertraline in rats
Ilgın, Sinem; Kılıç, Volkan; Baysal, Merve; Aydoğan Kılıç, Gözde; Uçarcan, Şeyda; Dermenci, Begüm; Atlı Eklioğlu, Özlem (Royal Soc Chemistry, 2018)Sertraline is an antidepressant that is frequently prescribed to treat depression, obsessive-compulsive disorder, panic disorder, and anxiety. This drug had a safe cardiotoxicity profile, until the reporting of cases of ...