Yazar "Anadolu Üniversitesi, Eczacılık Fakültesi, Farmasötik Toksikoloji Anabilim Dalı" için Makale Koleksiyonu listeleme
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Evidence for neurotoxicity associated with amoxicillin in juvenile rats
Atlı Eklioğlu, Özlem; Demir-Özkay, U.; Ilgın, Sinem; Aydın, T. H.; Akbulut, E. N.; Şener, E. (SAGE Publications LTD, 2016)Amoxicillin (AMX) is one of the most commonly prescribed antibiotics for children, and childhood is the period to have the highest risk for toxicity cases including drug-induced adverse reactions. Some neurological adverse ... -
Insulin Neuropathy: Rare Adverse Effect of Insulin Therapy
Ergün, Bülent (Ibn Sina Trust, 2016)Insulin neuropathy is a rare adverse effect of insulin therapy in patients with long-term uncontrolled hyperglycemia. Neuropathic pain appears after the correction of blood glucose level. A 34 years old woman with severe ... -
Insulin neuropathy: Rare adverse effect of insulin therapy
Ergün, Bülent (Ibn Sina Trust, 2016)Insulin neuropathy is a rare adverse effect of insulin therapy in patients with long-term uncontrolled hyperglycemia. Neuropathic pain appears after the correction of blood glucose level. A 34 years old woman with severe ... -
Matrix metalloproteinases are possible targets in monocrotaline-induced pulmonary hypertension: investigation of anti-remodeling effects of alagebrium and everolimus
Atlı Eklioğlu, Özlem; Ilgın, Sinem; Ergün, Bülent; Burukoğlu, Dilek; Musmul, Ahmet; Sırmagül, Başar (Turkish Soc Cardiology, 2017)Objective: In our study, sildenafil alone and everolimus or alagebrium in combination with sildenafil were investigated in terms of their additional therapeutic and anti-remodeling activity in monocrotaline-induced pulmonary ... -
Novel Benzylidene Thiazolidinedione Derivatives as Partial PPAR gamma Agonists and their Antidiabetic Effects on Type 2 Diabetes
Yasmin, Sabina; Capone, Fabio; Laghezza, Antonio; Dal Piaz, Fabrizio; Loiodice, Fulvio; Vijayan, Viswanathan; Lavecchia, Antonio (Nature Publishing Group, 2017)Peroxisome proliferator-activated receptor gamma (PPAR gamma) has received significant attention as a key regulator of glucose and lipid homeostasis. In this study, we synthesized and tested a library of novel 5-benzylid ... -
Oxidative stress-mediated myrocardiotoxicity of ciprofloxacin and ofloxacin in juvenile rats
Saraçoğlu, Ahmet; Temel, Halide Edip; Ergün, Bülent; Çolak, Ömer (Taylor & Francis Inc, 2009)In this study, evaluation of the myocardiotoxic effect potential of ciprofloxacin and ofloxacin in juvenile rats and the role of oxidative stress in heart toxicity was conducted. Doses (25 and 50 mg/kg) of each drug were ... -
Reproductive toxic effects and possible mechanisms of zonisamide in male rats
Karaduman, A. B.; Kılıç, Volkan; Atli-Eklioğlu, O.; Baysal, Merve; Aydoğan Kılıç, Gözde; Ucarcan, S.; Ilgın, Sinem (SAGE Publications Ltd, 2019)Zonisamide (ZNS) is an anticonvulsant which is used to treat the symptoms of epilepsy. Although it is frequently used during reproductive ages, studies that investigated the effects of ZNS on reproductive system are limited. ... -
Reproductive toxicity after levetiracetam administration in male rats: Evidence for role of hormonal status and oxidative stress
Baysal, Merve; Ilgın, Sinem; Aydoğan Kılıç, Gözde; Kılıç, Volkan; Uçarcan, Şeyda; Atlı Eklioğlu, Özlem (Public Library Science, 2017)Levetiracetam (LEV) is an antiepileptic drug commonly used in the treatment of epilepsy because of its excellent safety profile in all age groups. It is remarkable that there are no studies evaluating the toxic effects of ... -
Sertraline-induced reproductive toxicity in male rats: evaluation of possible underlying mechanisms
Atlı Eklioğlu, Özlem; Baysal, Merve; Aydoğan Kılıç, Gözde; Kılıç, Volkan; Uçarcan, Şeyda; Karaduman, Abdullah Burak; Ilgın, Sinem (Wolters Kluwer Medknow Publications, 2017)This study was conducted to clarify the toxic effects of sertraline (SRT) on the reproductive system of male rats and to elucidate the underlying mechanisms. Rats were treated orally with SRT at doses of 5, 10, and 20 mg ... -
Studies on controlled release dimenhydrinate from matrix tablet formulations
Genç, Lütfi; Bilaç, H.; Güler, E. (1999)In this study, controlled release dosage forms of dimenhydrinate were prepared with different polymers as MC, HEC, Carbopol 934, Eudragit RLPM and Eudragit NE 30 D at different concentrations (2.5-10%). Direct compression ... -
Synthesis and MAO inhibitory activity of novel thiazole-hydrazones
Atlı Eklioğlu, Özlem; Özkay, Yusuf (Scientific Technical Research Council Turkey-Tubitak, 2017)A series of new thiazole-hydrazones (3a-3n) were synthesized, characterized, and screened for their hMAO-A and hMAO-B inhibitory activity by an in vitro fluorometric method. Selectivity indexes (SIs) were expressed as IC50 ... -
Toxic Effects of Trazodone on Male Reproductive System via Disrupting Hypothalamic-Pituitary-Testicular Axis and Inducing Testicular Oxidative Stress
Ilgın, Sinem; Aydoğan-Kılıç, Gözde; Baysal, Merve; Kılıç, Volkan; Ardıç, Mina; Uçarcan, Şeyda; Atlı Eklioğlu, Özlem (Hindawi LTD, 2018)Depression and anxiety are recognized as public health problems. Epidemiological studies have shown that depression and anxiety often occur during reproductive ages between 20 and 60 years of age in males. Trazodone is one ... -
Validated reversed phase HPLC method for the analysis of the food additive, sodium benzoate, in soft drinks and jams
Altıokka, Göksel; Ergün, Bülent; Can, Nafiz Öncü; Aboul-Enein, Hassan Y. (Taylor & Francis Inc, 2007)A rapid, simple, and sensitive method is described for the determination of the food preservative sodium benzoate in soft drinks, various jams, and ketchup. The method utilizes high performance liquid chromatography followed ...