Yazar "Atlı Eklioğlu, Özlem" için Makale Koleksiyonu listeleme
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Acute and Subchronic Toxic Effects of the Fruits of Physalis peruviana L.
Perk, Başak Özlem; Ilgın, Sinem; Atlı Eklioğlu, Özlem; Duymuş, Hale Gamze; Sırmagül, Başar (Hindawi Publishing Corporation, 2013)The fruit of Physalis peruviana L. (PPL) has been traditionally used as antispasmodic, diuretic, antiseptic, sedative, and analgesic all over the world. We aimed to perform qualitative content analysis of the fruits of PPL ... -
Acute drug poisonings in Eskisehir, Turkey: A retrospective study
Ergün, Bülent; Çevik, Alper Arif; Ilgın, Sinem; Atlı Eklioğlu, Özlem; Saraçoğlu, Ahmet; Acar, Nurdan (2013)Bu çalışmada ESOGU Tıp Fakültesi Hastanesi Yetişkin Acil Servisine Ocak 2003 - Aralık 2009 yılları arasında başvuran akut ilaç zehirlenme olgularının retrospektif olarak değerlendirilmesi amaçlanmaktadır. Bu amaçla olgulara ... -
Acute drug poisonings in Eskisehir, Turkey: A retrospective study [Eskişehirde akut i·laç zehirlenmeleri: Retrospektif bir çahşma]
Ergün, Bülent; Çevik, Alper Arif; Ilgın, Sinem; Atlı Eklioğlu, Özlem; Saraçoğlu, Ahmet; Acar, N.; Uzuncakara, D. (2013)The aim of this study was to characterize acute drug-poisoning cases admitted to the Adult Emergency Service of ESOGU Medicine Faculty Hospital, Turkey. All acute drug-poisoning cases admitted to the emergency service from ... -
Assessment of the Endothelial Functions in Monocrotaline-induced Pulmonary Hypertension
Sırmagül, Başar; Ilgın, Sinem; Atlı Eklioğlu, Özlem; Usanmaz, Suzan Emel; Demirel-Yılmaz, Emine (Taylor & Francis Inc, 2013)Pulmonary hypertension (PH) is a life-threatening disease that causes endothelial dysfunction in the pulmonary vascular bed. Systemic endothelial dysfunction has also been reported in PH. This study compared the systemic ... -
Assessment of trazodone-induced cardiotoxicity after repeated doses in rats
Atlı Eklioğlu, Özlem; Kılıç, Volkan; Baysal, Merve; Aydoğan Kılıç, Gözde; Gormus, G.; Ucarcan, S.; Ilgın, Sinem (SAGE Publications LTD, 2019)Trazodone (TRZ) is an antidepressant drug commonly used in the treatment of depression, anxiety, and insomnia. Although some studies demonstrated the adverse effects of TRZ related to cardiovascular system, the conflicting ... -
Biotransformation of abietic acid by fungi and biological evaluation of its metabolites
Özşen, Özge; Kıran, İsmail; Dağ, İlknur; Atlı Eklioğlu, Özlem; Çiftçi, Gülsen Akalın; Demirci, Fatih (Elsevier Sci LTD, 2017)Biotransformation of abietic acid was carried out initially using 28 different microbial strains. Among the evaluated, Mucor ramannianus produced a known metabolite namely 2 alpha-hydroxy-dehydroabietic acid whereas ... -
Ciprofloxacin-induced neurotoxicity: evaluation of possible underlying mechanisms
Ilgın, Sinem; Can, Özgür Devrim; Atlı Eklioğlu, Özlem; Ucel, Umut İrfan; Şener, Erol; Güven, İlkay (Taylor & Francis LTD, 2015)Ciprofloxacin (CPX) is a fluoroquinolone antibiotic used for treating respiratory, urinary tract, gastrointestinal and abdominal infections. There are only a limited number of studies related to neurological adverse effects ... -
Citalopram Induces Reproductive Toxicity in Male Rats
Ilgın, Sinem; Aydoğan-Kılıc, G.; Baysal, Merve; Kılıç, Volkan; Korkut, Büşra; Uçarcan, Şeyda; Atlı Eklioğlu, Özlem (Wiley, 2017)Background: Citalopram hydrobromide (CTL) has been shown to cause sexual dysfunction; however, its reproductive toxicity potential has not been sufficiently elucidated in men. Therefore, we aimed to clarify the toxic effects ... -
The effect of combination therapy on the plasma concentrations of traditional antiepileptics: A retrospective study
Sırmagül, B.; Atlı Eklioğlu, Özlem; Ilgın, Sinem (SAGE Publications LTD, 2012)The present study aimed at determining the differences in plasma concentrations of traditional antiepileptics such as phenytoin, carbamazepine, and valproic acid in patients receiving monotherapy and combination therapy. ... -
Effects of Everolimus in Combination with Sildenafil in Monocrotaline-induced Pulmonary Hypertension in Rats
Ilgın, Sinem; Burukoğlu, Dilek; Atlı Eklioğlu, Özlem; Sırmagül, Başar (Humana Press Inc, 2012)In our study, we investigated the efficacy of everolimus in combination with sildenafil on hemodynamic and morphological parameters in rats with monocrotaline-induced pulmonary hypertension (PH). Right ventricular pressure ... -
The effects of gender difference on monocrotaline-induced pulmonary hypertension in rats
Bal, E.; Ilgın, Sinem; Atlı Eklioğlu, Özlem; Ergün, Bülent; Sırmagül, Başar (SAGE Publications LTD, 2013)The present study aimed to compare the effect of gender difference on hemodynamic consequences in the development of monocrotaline (MCT)-induced pulmonary hypertension in rat. The effect of antioxidant enzyme systems on ... -
Evaluation of azithromycin induced cardiotoxicity in rats
Atlı Eklioğlu, Özlem; Ilgın, Sinem; Altuntaş, Hakan; Burukoğlu, Dilek (E-Century Publishing Corp, 2015)Although there are possible cardiovascular adverse effects associated with the azithromycin treatment according to some case reports and cohort studies, there is no experimental study evaluating cardiotoxicity in repeated ... -
Evaluation of the reproductive toxicity of naproxen sodium and meloxicam in male rats
Uzun, B.; Atlı Eklioğlu, Özlem; Perk, B. O.; Burukoğlu, D.; Ilgın, Sinem (SAGE Publications LTD, 2015)Nonsteroidal anti-inflammatory drugs that are cyclooxygenase (COX) enzyme inhibitors have generally been used in short-term pain management and also to treat inflammation chronically. It is known that COX enzyme and ... -
Evidence for cardiotoxicity associated with sertraline in rats
Ilgın, Sinem; Kılıç, Volkan; Baysal, Merve; Aydoğan Kılıç, Gözde; Uçarcan, Şeyda; Dermenci, Begüm; Atlı Eklioğlu, Özlem (Royal Soc Chemistry, 2018)Sertraline is an antidepressant that is frequently prescribed to treat depression, obsessive-compulsive disorder, panic disorder, and anxiety. This drug had a safe cardiotoxicity profile, until the reporting of cases of ... -
Evidence for neurotoxicity associated with amoxicillin in juvenile rats
Atlı Eklioğlu, Özlem; Demir-Özkay, U.; Ilgın, Sinem; Aydın, T. H.; Akbulut, E. N.; Şener, E. (SAGE Publications LTD, 2016)Amoxicillin (AMX) is one of the most commonly prescribed antibiotics for children, and childhood is the period to have the highest risk for toxicity cases including drug-induced adverse reactions. Some neurological adverse ... -
Matrix metalloproteinases are possible targets in monocrotaline-induced pulmonary hypertension: investigation of anti-remodeling effects of alagebrium and everolimus
Atlı Eklioğlu, Özlem; Ilgın, Sinem; Ergün, Bülent; Burukoğlu, Dilek; Musmul, Ahmet; Sırmagül, Başar (Turkish Soc Cardiology, 2017)Objective: In our study, sildenafil alone and everolimus or alagebrium in combination with sildenafil were investigated in terms of their additional therapeutic and anti-remodeling activity in monocrotaline-induced pulmonary ... -
Reproductive toxicity after levetiracetam administration in male rats: Evidence for role of hormonal status and oxidative stress
Baysal, Merve; Ilgın, Sinem; Aydoğan Kılıç, Gözde; Kılıç, Volkan; Uçarcan, Şeyda; Atlı Eklioğlu, Özlem (Public Library Science, 2017)Levetiracetam (LEV) is an antiepileptic drug commonly used in the treatment of epilepsy because of its excellent safety profile in all age groups. It is remarkable that there are no studies evaluating the toxic effects of ... -
Sertraline-induced reproductive toxicity in male rats: evaluation of possible underlying mechanisms
Atlı Eklioğlu, Özlem; Baysal, Merve; Aydoğan Kılıç, Gözde; Kılıç, Volkan; Uçarcan, Şeyda; Karaduman, Abdullah Burak; Ilgın, Sinem (Wolters Kluwer Medknow Publications, 2017)This study was conducted to clarify the toxic effects of sertraline (SRT) on the reproductive system of male rats and to elucidate the underlying mechanisms. Rats were treated orally with SRT at doses of 5, 10, and 20 mg ... -
Synthesis and MAO inhibitory activity of novel thiazole-hydrazones
Atlı Eklioğlu, Özlem; Özkay, Yusuf (Scientific Technical Research Council Turkey-Tubitak, 2017)A series of new thiazole-hydrazones (3a-3n) were synthesized, characterized, and screened for their hMAO-A and hMAO-B inhibitory activity by an in vitro fluorometric method. Selectivity indexes (SIs) were expressed as IC50 ... -
Toxic Effects of Trazodone on Male Reproductive System via Disrupting Hypothalamic-Pituitary-Testicular Axis and Inducing Testicular Oxidative Stress
Ilgın, Sinem; Aydoğan-Kılıç, Gözde; Baysal, Merve; Kılıç, Volkan; Ardıç, Mina; Uçarcan, Şeyda; Atlı Eklioğlu, Özlem (Hindawi LTD, 2018)Depression and anxiety are recognized as public health problems. Epidemiological studies have shown that depression and anxiety often occur during reproductive ages between 20 and 60 years of age in males. Trazodone is one ...