Studies on thiazolyliminothiazoline derivatives as potential antitubercular agents

Abstract

In this study, eight new ethyl {2-[3,4-diaryl-3H-thiazol-2-ylidenamino] thiazol-4-yl}acetate were synthesized by reacting ethyl [2-(3-aryl(thiouredio) thiazol-4-yl]acetate and phenacyl bromides in ethanol. The solid was filtered and recrystallized from ethanol. The chemical structures of the synthesized compounds were proven by elemental analysis, IR, 1H-NMR and MS spectral data. The compounds were evaluated for in vitro antituberculosis activity against Mycobacterium tuberculosis H37Rv using the BACTEC 460 radiometric system and BACTEC 12B medium. The preliminary results showed that all of the tested compounds were inactive against the test organism.