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dc.contributor.authorYurttaş, Leyla
dc.contributor.authorŞahin, Z.
dc.contributor.authorEr, S.
dc.contributor.authorDemirayak, Şeref
dc.date.accessioned2019-10-19T16:02:34Z
dc.date.available2019-10-19T16:02:34Z
dc.date.issued2016
dc.identifier.issn1307-2080
dc.identifier.urihttps://dx.doi.org/10.23893/1307-2080.APS.0544
dc.identifier.urihttps://hdl.handle.net/11421/13807
dc.description.abstractIn this work, six novel 4-aryl-2-[2-((5-nitrofuran-2-yl)methylene)hydrazinyl] thiazole derivatives (2a-f) were synthesized starting from 5-nitro-2-furaldehyde diacetate by using Hantzsch thiazole synthesis. The antimicrobial activity of the title compounds were screened against five Gram positive bacteria B. cereus, E. faecalis, S. aureus, S. epidermidis, L. monocytogenes and two Gram negative bacteria E. coli and S. typhi. MIC and MBC were calculated and compared to standard drug nitrofurazone. Compounds bearing pyridine moiety (2d-e) exhibited significant antimicrobial activity which could be evaluated as new, potent antibacterial agentsen_US
dc.language.isoengen_US
dc.publisherUniversity of Istanbulen_US
dc.relation.isversionof10.23893/1307-2080.APS.0544en_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAntibacterial Activityen_US
dc.subjectNitrofuransen_US
dc.subjectNitrofurazoneen_US
dc.subjectThiazoleen_US
dc.titleSynthesis and antimicrobial activity evaluation of novel nitrofuranthiazolesen_US
dc.typearticleen_US
dc.relation.journalActa Pharmaceutica Scienciaen_US
dc.contributor.departmentAnadolu Üniversitesi, Eczacılık Fakültesi, Farmasötik Kimya Anabilim Dalıen_US
dc.identifier.volume54en_US
dc.identifier.issue1en_US
dc.identifier.startpage43en_US
dc.identifier.endpage52en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US]
dc.contributor.institutionauthorYurttaş, Leyla
dc.contributor.institutionauthorDemirayak, Şeref


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