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dc.contributor.authorYurtdaş Kırımlıoğlu, Gülsel
dc.contributor.authorÖzer, Sinan
dc.contributor.authorBüyükköroğlu, Gülay
dc.contributor.authorYazan, Yasemin
dc.date.accessioned2019-10-19T16:02:40Z
dc.date.available2019-10-19T16:02:40Z
dc.date.issued2018
dc.identifier.issn0326-2383
dc.identifier.urihttps://hdl.handle.net/11421/13865
dc.descriptionWOS: 000446302000021en_US
dc.description.abstractThe primary purpose of this study was to extend the time of interaction of the carrier with the negatively charged ocular surface for enhanced penetration in order to improve ocular bioavailability. Moxifloxacin hydrochloride (MOX) was successfully incorporated into cationic Eudragit (R) RS 100 nanoparticles (NPs) by spray-drying process. Particle size and zeta potential measurements, entrapment efficiency, morphological, thermal, FTIR and NMR analyses and MOX quantification by high performance liquid chromatography (HPLC) method were performed for characterizing the formulations prepared. In vitro release profiles indicated prolonged release of MOX from NPs which followed Korsmeyer-Peppas kinetic model. Cytotoxicity results showed that pure MOX and MOX-loaded NPs were not toxic at all concentrations for 24 h. Moreover, NPs remained stable for 3 months of storage under accelerated conditions. Conclusively, depending on the in vitro results obtained in this study, Eudragit (R) RS 100 NPs seem to be promising for enhancement of ocular bioavailability of MOX.en_US
dc.description.sponsorshipAnadolu University Scientific Research Project Foundation [1603S112]en_US
dc.description.sponsorshipThe authors would like to thank to Exp.Chem. Serkan Levent for his assistance in FTIR and NMR analyses and Assoc. Prof.Dr. Ozer Gok for his help in taking SEM images. This study was financed by Anadolu University Scientific Research Project Foundation (No: 1603S112).en_US
dc.language.isoengen_US
dc.publisherColegio Farmaceuticos Provincia De Buenos Airesen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectEudragit (R) Rs 100en_US
dc.subjectMoxifloxacin Hydrochlorideen_US
dc.subjectOcular Deliveryen_US
dc.subjectPolymeric Nanoparticleen_US
dc.subjectSpray-Dryingen_US
dc.titleFormulation and In Vitro Evaluation of Moxifloxacin Hydrochloride-Loaded Polymeric Nanoparticles for Ocular Applicationen_US
dc.typearticleen_US
dc.relation.journalLatin American Journal of Pharmacyen_US
dc.contributor.departmentAnadolu Üniversitesi, Eczacılık Fakültesi, Farmasötik Teknoloji Anabilim Dalıen_US
dc.identifier.volume37en_US
dc.identifier.issue9en_US
dc.identifier.startpage1850en_US
dc.identifier.endpage1862en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US]
dc.contributor.institutionauthorBüyükköroğlu, Gülay
dc.contributor.institutionauthorYazan, Yasemin


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