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dc.contributor.authorYurtdaş Kırımlıoğlu, Gülsel
dc.contributor.authorGörgülü, Sennur
dc.date.accessioned2019-10-19T16:02:40Z
dc.date.available2019-10-19T16:02:40Z
dc.date.issued2019
dc.identifier.issn0326-2383
dc.identifier.urihttps://hdl.handle.net/11421/13866
dc.descriptionWOS: 000478794500012en_US
dc.description.abstractThe objective of this research was to design and characterize montelukast sodium (MS) loaded novel nanosized and biocompatible Kollidon (R) SR nanoparticles to provide prolonged release behavior that can improve bioavailability, reduce side effects and give better efficacy in the therapy of chronic asthma. Particle size and zeta potential measurements, morphological, thermal, FTIR, NMR analyses, MS quantification by modified HPLC method were used for characterizing the formulations prepared. Cytotoxicity studies were realized to confirm the safety of formulations. Formulations showed smaller particle size (421-438 nm) with narrow size distribution and negatively charged characteristics. Drug release was extended more than 10 fold with nanoparticles indicated diffusion controlled release from polymeric matrix. Cytotoxicy studies revealed the safety and biocompatibility of the particles with higher cell viability values than MS. These findings suggest that MS loaded nanoparticles seem to be a promising drug delivery system for the sustained release of MS.en_US
dc.language.isoengen_US
dc.publisherColegio Farmaceuticos Provincia De Buenos Airesen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCytotoxicityen_US
dc.subjectKollidon (R) Sren_US
dc.subjectMontelukast Sodiumen_US
dc.subjectNanoparticleen_US
dc.subjectRelease Kineticen_US
dc.subjectSustained Releaseen_US
dc.titleDesign and Characterization of Montelukast Sodium Loaded Kollidon (R) SR Nanoparticles and Evaluation of Release Kinetics and Cytotoxicity Potentialen_US
dc.typearticleen_US
dc.relation.journalLatin American Journal of Pharmacyen_US
dc.contributor.departmentAnadolu Üniversitesi, Eczacılık Fakültesi, Farmasötik Teknoloji Anabilim Dalıen_US
dc.identifier.volume38en_US
dc.identifier.issue7en_US
dc.identifier.startpage1350en_US
dc.identifier.endpage1360en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US]


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