| dc.contributor.author | Alper, Öztürk, A. | |
| dc.contributor.author | Çınar, Nur İlge | |
| dc.contributor.author | Yenilmez, Evrim | |
| dc.date.accessioned | 2019-10-19T16:02:45Z | |
| dc.date.available | 2019-10-19T16:02:45Z | |
| dc.date.issued | 2019 | |
| dc.identifier.issn | 0719-4250 | |
| dc.identifier.uri | https://hdl.handle.net/11421/13907 | |
| dc.description.abstract | Context: Pain has a very important effect on the biological, psychological, sociological and economic situation of a patient. Nanoparticles (NPs) are being extensively investigated as drug delivery systems worldwide for pharmaceutical applications. Aims: To design and compare the release characteristics of sustained-release formulations of ketoprofen lysine (KL) NPs. Methods: KL-Eudragit® S100 NPs were produced by double emulsion solvent evaporation method. The physicochemical characteristics of NPs were studied. Results: Particle size of NPs prepared was in the range of 99 and 141 nm. Encapsulation efficiency (%) was obtained (76%) for NP formulations prepared. Weibull models were determined to be the most appropriate kinetic models for NP containing KL. KL-loaded NPs demonstrated nanostructural character and NPs showed extended release of KL. Conclusions: NPs developed were found to be stable and representing a promising system for sustained delivery of KL | en_US |
| dc.language.iso | eng | en_US |
| dc.publisher | Academic Association of Pharmaceutical Sciences from Antofagasta (ASOCIFA) | en_US |
| dc.rights | info:eu-repo/semantics/closedAccess | en_US |
| dc.subject | Eudragit® S100 | en_US |
| dc.subject | Ketoprofen Lysine | en_US |
| dc.subject | Nanoparticle | en_US |
| dc.title | Development of nano-sized ketoprofen lysine incorporated Eudragit® S100 nanomedicine by double emulsion solvent evaporation and in vitro characterization | en_US |
| dc.type | article | en_US |
| dc.relation.journal | Journal of Pharmacy and Pharmacognosy Research | en_US |
| dc.contributor.department | Anadolu Üniversitesi, Eczacılık Fakültesi, Farmasötik Teknoloji Anabilim Dalı | en_US |
| dc.identifier.volume | 7 | en_US |
| dc.identifier.issue | 1 | en_US |
| dc.identifier.startpage | 47 | en_US |
| dc.identifier.endpage | 58 | en_US |
| dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US] |
