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dc.contributor.authorAtlı Eklioğlu, Özlem
dc.contributor.authorBaysal, Merve
dc.contributor.authorAydoğan Kılıç, Gözde
dc.contributor.authorKılıç, Volkan
dc.contributor.authorUçarcan, Şeyda
dc.contributor.authorKaraduman, Abdullah Burak
dc.contributor.authorIlgın, Sinem
dc.date.accessioned2019-10-19T16:02:47Z
dc.date.available2019-10-19T16:02:47Z
dc.date.issued2017
dc.identifier.issn1008-682X
dc.identifier.issn1745-7262
dc.identifier.urihttps://dx.doi.org/10.4103/1008-682X.192637
dc.identifier.urihttps://hdl.handle.net/11421/13923
dc.descriptionWOS: 000413790500010en_US
dc.descriptionPubMed ID: 27976631en_US
dc.description.abstractThis study was conducted to clarify the toxic effects of sertraline (SRT) on the reproductive system of male rats and to elucidate the underlying mechanisms. Rats were treated orally with SRT at doses of 5, 10, and 20 mg kg(-1) for 28 consecutive days. At the end of the treatment period, sperm concentration, sperm motility, and sperm morphology were investigated by computer-assisted sperm analysis system whereas sperm DNA damage was detected by comet assay. The oxidative status of the testes was investigated, and a histopathological examination was conducted. Serum testosterone, follicle-stimulating hormone (FSH), and luteinizing hormone (LH) levels were measured to determine the effects of SRT on the spermatogenesis process. One-way ANOVA, post-hoc Dunnett's T3 test for the sperm comet assay, and post-hoc Tukey's test for the others were performed for statistical analysis. The results showed that SRT caused an increase in sperm DNA damage and induced histopathological lesions in all groups treated with SRT. There was abnormal sperm morphology and increased malondialdehyde (MDA) in the 10 mg kg(-1) treatment group. More dramatic changes were observed in the 20 mg kg(-1) treatment group. Decreased sperm count was accompanied by a significant increase in abnormal sperm morphology, DNA damage, and degeneration in cellular-tubular structures. Serum LH and testosterone levels were elevated in the 20 mg kg(-1) treatment group. Decreased glutathione (GSH) and increased MDA were signs of enhanced oxidative stress (OS). In conclusion, SRT induced testicular toxicity in a dose-dependent manner and OS is suggested as a crucial mechanism.en_US
dc.description.sponsorshipAnadolu University Scientific Research Projects Commission [1404S128]en_US
dc.description.sponsorshipThis study was supported by the Anadolu University Scientific Research Projects Commission under the grant no. 1404S128.en_US
dc.language.isoengen_US
dc.publisherWolters Kluwer Medknow Publicationsen_US
dc.relation.isversionof10.4103/1008-682X.192637en_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectDna Damageen_US
dc.subjectOxidative Stressen_US
dc.subjectReproductive Toxicityen_US
dc.subjectSertralineen_US
dc.titleSertraline-induced reproductive toxicity in male rats: evaluation of possible underlying mechanismsen_US
dc.typearticleen_US
dc.relation.journalAsian Journal of Andrologyen_US
dc.contributor.departmentAnadolu Üniversitesi, Eczacılık Fakültesi, Farmasötik Toksikoloji Anabilim Dalıen_US
dc.identifier.volume19en_US
dc.identifier.issue6en_US
dc.identifier.startpage672en_US
dc.identifier.endpage679en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US]
dc.contributor.institutionauthorAtlı Eklioğlu, Özlem
dc.contributor.institutionauthorAydoğan Kılıç, Gözde
dc.contributor.institutionauthorKılıç, Volkan
dc.contributor.institutionauthorUçarcan, Şeyda
dc.contributor.institutionauthorIlgın, Sinem


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