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dc.contributor.authorIlgın, Sinem
dc.contributor.authorBurukoğlu, Dilek
dc.contributor.authorAtlı Eklioğlu, Özlem
dc.contributor.authorSırmagül, Başar
dc.date.accessioned2019-10-19T16:02:49Z
dc.date.available2019-10-19T16:02:49Z
dc.date.issued2012
dc.identifier.issn1530-7905
dc.identifier.urihttps://dx.doi.org/10.1007/s12012-011-9137-8
dc.identifier.urihttps://hdl.handle.net/11421/13938
dc.descriptionWOS: 000299919100005en_US
dc.descriptionPubMed ID: 21811847en_US
dc.description.abstractIn our study, we investigated the efficacy of everolimus in combination with sildenafil on hemodynamic and morphological parameters in rats with monocrotaline-induced pulmonary hypertension (PH). Right ventricular pressure (RVP), right ventricular hypertrophy, and the response to vasoconstrictor and vasodilator agents in pulmonary arteries as evaluated by myography and histopathological changes were compared among the groups. RVP and right ventricle/body weight ratios were increased in non-treated monocrotaline groups versus the controls; these increased ratios were decreased in the treated groups and were similar to control values. The contractile responses to endothelin-1 in the pulmonary arteries were decreased in the non-treated monocrotaline groups versus the control. In the treatment groups, contractile responses were similar to those in the controls. Responses to acetylcholine and sodium nitroprusside relaxation were decreased in non-treated monocrotaline groups but were improved significantly in the everolimus groups. Upon histopathological examination, the vascular hypertrophy and cardiac hypertrophy observed in monocrotaline groups were improved by the sildenafil and everolimus treatment. In particular, these improvements became remarkable, including the inflammatory changes, in the everolimus treatment groups. In the light of these results, sildenafil and everolimus in combination were more effective than sildenafil treatment alone in reversing the remodelling process without any cardiovascular toxic effects in the monocrotaline-induced PH model.en_US
dc.language.isoengen_US
dc.publisherHumana Press Incen_US
dc.relation.isversionof10.1007/s12012-011-9137-8en_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectPulmonary Hypertensionen_US
dc.subjectVascular Remodellingen_US
dc.subjectMonocrotalineen_US
dc.subjectSildenafilen_US
dc.subjectEverolimusen_US
dc.titleEffects of Everolimus in Combination with Sildenafil in Monocrotaline-induced Pulmonary Hypertension in Ratsen_US
dc.typearticleen_US
dc.relation.journalCardiovascular Toxicologyen_US
dc.contributor.departmentAnadolu Üniversitesi, Eczacılık Fakültesi, Farmasötik Toksikoloji Anabilim Dalıen_US
dc.identifier.volume12en_US
dc.identifier.issue1en_US
dc.identifier.startpage46en_US
dc.identifier.endpage55en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US]
dc.contributor.institutionauthorIlgın, Sinem
dc.contributor.institutionauthorAtlı Eklioğlu, Özlem


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