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dc.contributor.authorBayramoğlu, Gülay
dc.contributor.authorBitirim, Verda
dc.contributor.authorTunalı, Yağmur
dc.contributor.authorArıca, Mehmet Yakup
dc.contributor.authorAkçalı, Kamil Can
dc.date.accessioned2019-10-19T16:02:57Z
dc.date.available2019-10-19T16:02:57Z
dc.date.issued2013
dc.identifier.issn0928-4931
dc.identifier.issn1873-0191
dc.identifier.urihttps://dx.doi.org/10.1016/j.msec.2012.11.004
dc.identifier.urihttps://hdl.handle.net/11421/13990
dc.descriptionWOS: 000315761700033en_US
dc.descriptionPubMed ID: 25427490en_US
dc.description.abstractCopolymerization of 2-hydroxyethylmethactylate (HEMA) with glycidylmethacrylate (GMA) in the presence of alpha-alpha'-azoisobisbutyronitrile (AIBN) resulted in the formation of hydrogel films carrying reactive epoxy groups. Thirteen kinds of different molecules with pendant -NH2 group were used for modifications of the p(HEMA-GMA) films. The -NH2 group served as anchor binding site for immobilization of functional groups on the hydrogel film via direct epoxy ring opening reaction. The modified hydrogel films were characterized by FTIR, and contact angle studies. In addition, mechanical properties of the hydrogel films were studied, and modified hydrogel films showed improved mechanical properties compared with the non-modified film, but they are less elastic than the non-modified film. The biological activities of these films such as platelet adhesion, red blood cells hemolysis, and swelling behavior were studied. The effect of modified hydrogel films, including -NH2, (using different aliphatic -CH2 chain lengths) -CH3, -SO3H, aromatic groups with substituted -OH and -COOH groups, and amino acids were also investigated on the adhesion, morphology and survival of rat mesenchymal stem cells (MSCs). The MTT colorimetric assay reveals that the p(HEMA-GMA)-GA-AB, p(HEMA-GMA)-GA-Phe, p(HEMA-GMA)-GA-Trp, p(HEMA-GMA)-GA-Glu formulations have an excellent biocompatibility to promote the cell adhesion and growth. We anticipate that the fabricated p(HEMA-GMA) based hydrogel films with controllable surface chemistry and good stable swelling ratio may find extensive applications in future development of tissue engineering scaffold materials, and in various biotechnological areasen_US
dc.language.isoengen_US
dc.publisherElsevier Science BVen_US
dc.relation.isversionof10.1016/j.msec.2012.11.004en_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectHydrogelsen_US
dc.subjectBiocompatible Polymersen_US
dc.subjectContact Angleen_US
dc.subjectBlood Cell Adhesionen_US
dc.subjectHemolysisen_US
dc.subjectRat Mesenchymal Stem Cellsen_US
dc.titlePoly (hydroxyethyl methacrylate-glycidyl methacrylate) films modified with different functional groups: In vitro interactions with platelets and rat stem cellsen_US
dc.typearticleen_US
dc.relation.journalMaterials Science & Engineering C-Materials For Biological Applicationsen_US
dc.contributor.departmentAnadolu Üniversitesi, Eczacılık Fakültesi, Mikrobiyoloji Anabilim Dalıen_US
dc.identifier.volume33en_US
dc.identifier.issue2en_US
dc.identifier.startpage801en_US
dc.identifier.endpage810en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US]
dc.contributor.institutionauthorTunalı, Yağmur


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