Yazar "Can, Özgür Devrim" için Fakülteler listeleme
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Effect of benzothiazole/piperazine derivatives on intracerebroventricular streptozotocin-induced cognitive deficits
Özkay, Ümide Demir; Can, Özgür Devrim; Özkay, Yusuf; Öztürk, Yusuf (Polish Acad Sciences Inst Pharmacology, 2012)Background: In this study, benzothiazolc-piperazine compounds were synthesized by condensing the functional groups of donepezil (DNP), FK-960, and sabeluzole, which are known to have therapeutic potential against Alzheimer's ... -
Effect of mianserin on streptozotocin-induced hyperglycemia and metabolic alterations in rats
Can, Özgür Devrim; Üçel, İrfan Umut; Özkay, Ümide Demir; Dikmen, Miriş (Çukurova University, Fac Medicine, 2017)Purpose: The aim of this study was to investigate possible effects of atypical antidepressant mianserin on glycemia levels and metabolic parameters of normoglycemic and diabetic rats Material and Methods: Effects of mianserin ... -
The effect of simvastatin treatment on behavioral parameters, cognitive performance, and hippocampal morphology in rats fed a standard or a high-fat diet
Can, Özgür Devrim; Ulupınar, Emel; Özkay, Ümide Demir; Yegin, Bengi; Öztürk, Yusuf (Lippincott Williams & Wilkins, 2012)The aim of this study was to examine the effect of simvastatin (SMV), a 3-hydroxy-3-methyl-glutaryl-CoA reductase inhibitor, in rats fed with a standard or a high-fat diet (HFD) throughout the prenatal and the postnatal ... -
Effect of subacute agomelatine treatment on painful diabetic neuropathy: involvement of catecholaminergic mechanisms
Aydın, Taliha H.; Can, Özgür Devrim; Özkay, Ümide Demir; Turan, Nazlı (Wiley, 2016)In this study, we investigated the effects of subacute agomelatine (40 and 80 mg/kg) administration on chronic hyperglycemia, metabolic parameters, and pain perception in streptozotocin-induced diabetic rats. Fasting blood ... -
Effects of hawthorn seed and pulp extracts on the central nervous system
Can, Özgür Devrim; Özkay, Ümide Demir; Öztürk, Nilgün; Öztürk, Yusuf (Informa Healthcare, 2010)Context: Investigating potential central nervous system (CNS) activities of Crataegus monogyna Jacq. (Rosaceae), hawthorn, fruit extracts. Objective: Evaluating CNS effects and analgesic activities of hawthorn fruit extracts ... -
Effects of Hypericum montbretti Extract on the Central Nervous System and Involvement of GABA (A)/Benzodiazepine Receptors in its Pharmacological Activity
Can, Özgür Devrim; Özkay, Ümide Demir (Wiley, 2012)The present study was undertaken to investigate the putative activity of a methanol extract of Hypericum montbretti (Guttiferae) on the central nervous system. Rutin (1519 ppm) and quercitrin (784 ppm) were identified as ... -
Effects of Insulin and St. John's Wort Treatments on Anxiety, Locomotory Activity, Depression, and Active Learning Parameters of Streptozotocin-Diabetic Rats
Can, Özgür Devrim; Öztürk, Yusuf; Özkay, Ümide Demir (Georg Thieme Verlag Kg, 2011)The aim of this work was to investigate the effects of St. John's Wort (SJW) extract treatment on behavioral changes arising in streptozotocin (STZ)-diabetic rats. Plus-maze, activity cage, modified forced swimming, and ... -
Effects of long-term agomelatine treatment on the cognitive performance and hippocampal plasticity of adult rats
Özkay, Ümide Demir; Soztutar, Erdem; Can, Özgür Devrim; Ucel, Umut İrfan; Öztürk, Yusuf; Ulupınar, Emel (Lippincott Williams & Wilkins, 2015)Agomelatine is an antidepressant with a distinct pharmacological mechanism of action as an MT1 and MT2 receptor agonist and as a 5-HT2C receptor antagonist. We evaluated the chronic effects of agomelatine administration ... -
Effects of Some 1,3,5-Trisubstitued-2-pyrazoline Derivatives on Depression and Anxiety Parameters of Mice
Can, Özgür Devrim; Özkay, Ümide Demir; Kaplancıklı, Zafer Asım; Öztürk, Yusuf (Pharmaceutical Soc Korea, 2009)The aim of the present study was examining the effects of some 1,3,5-trisubstituted-2-pyrazoline derivatives on depression, anxiety and spontaneous locomotor activity parameters of mice. None of the compounds was effective ... -
Effects of treatment with St. John's Wort on blood glucose levels and pain perceptions of streptozotocin-diabetic rats
Can, Özgür Devrim; Öztürk, Yusuf; Öztürk, Nilgün; Sagratini, Gianni; Ricciutelli, Massimo; Vittori, Sauro; Maggi, Filippo (Elsevier Science BV, 2011)This present study was undertaken to examine treating effects of St. John's Wort (SJW) extract on nociceptive perception of STZ-diabetic animals based on its potential antidiabetic and antinociceptive activities. One week ... -
An evaluation of the bottom ashes from healthcare waste in a laboratory scale incinerator: Microbiology, mutagenicity and toxicity
Malkoç, Semra; Banar, Müfide; Tüylü, Berrin; Korkmaz, S; Can, Özgür Devrim (Parlar Scientific Publications (PSP), 2006)In this study, experiments of healthcare waste incineration at 500, 600, 700, 800 and 900 degrees C in a lab-scale incinerator were carried out, performing different total bacterial counts for the microorganisms in bottom ... -
Huperzine A: A nootropic agent in the shade [Huperzin A: Gölgede Kalmış bir Nootropik Ajan]
Turan, Yücel, N.; Can, Özgür Devrim (Society of Pharmaceutical Sciences of Ankara (FABAD), 2019)Huperzine A is a sesquiterpene alkaloid found in the chemical composition of the medical plant Huperzia serrata. Huperzine A has attracted the attention of neuroscientists after the discovery of its strong and selective ... -
Investigating the Antidepressant-like Effects of some Benzimidazolepiperidine Derivatives by In-Vivo Experimental Methods
Turan, Nazlı; Özkay, Ümide Demir; Can, Nafiz Öncü; Can, Özgür Devrim (Bentham Science Publ LTD, 2019)Background: Benzimidazole and piperidine rings are important pharmacophore groups for drug design studies. Objective: In this study, we aimed to investigate the antidepressant-like activity of some 2-(4- substituted-phen ... -
MAO enzymes inhibitory activity of new benzimidazole derivatives including hydrazone and propargyl side chains
Can, Özgür Devrim; Osmaniye, Derya; Özkay, Ümide Demir; Sağlık, Begüm Nurpelin; Levent, Serkan; Ilgın, Sinem; Kaplancıklı, Zafer Asım (Elsevier France-Editions Scientifiques Medicales Elsevier, 2017)In the present work, 15 new N'-(arylidene)-4-(1-(prop-2-yn-1-yl)-1H-benzo[dlimidazol-2-yl)benzohydrazide (4a-4o) were designed and synthesized. The structures of the synthesized compounds were elucidated using FT-IR, ... -
Mianserin'in sıçanlarda streptozotosin ile indüklenen hiperglisemi ve metabolik değişiklikler üzerine etkisi
Amaç: Bu çalışmada, atipik bir antidepresan olan mianserin'in normoglisemik ve diyabetik sıçanlarda glisemi düzeyi ve metabolik parametreler üzerine olası etkilerinin araştırılması amaçlanmıştır. Gereç ve Yöntem: Mianserin'in ... -
Mianserin’in sıçanlarda streptozotosin ile indüklenen hiperglisemi ve metabolik değişiklikler üzerine etkisi
Amaç: Bu çalışmada, atipik bir antidepresan olan mianserin’in normoglisemik ve diyabetik sıçanlarda glisemi düzeyi ve metabolik parametreler üzerine olası etkilerinin araştırılması amaçlanmıştır. Gereç ve Yöntem: Mianserin’in ... -
Mirtazapin Diyabet Oluşturulan Sıçanların Beyinciklerindeki Hasarı Kısmen Düzeltmektedir
Diabetes mellitus (DM) sistemik bir hastalık olup çeşitli organlarda hasara neden olmaktadır. Bu organlar arasında beyincik de yer almaktadır. Mirtazapin ise majör depresyon tedavisinde kullanılan bir antidepresan madde ... -
Mirtazapine suppresses sterile inflammation through NLRP3-inflammasome in diabetic rat kidney
Şahin, Erhan; Bektur, Ezgi; Dönmez, Dilek Burukoğlu; Baycu, Cengiz; Can, Özgür Devrim; Şahintürk, Varol (Elsevier GMBH, 2019)Aim The aim of this study was to investigate the effects of mirtazapine, which is anti-oxidative and antidepressant agent, on the kidney damage caused by diabetes mellitus. Materials and methods: The rats were randomly ... -
A natural antidepressant: Hypericum perforatum L.: Review [Dogal Bir Antidepressan: Hypericum Perforatum L]
Can, Özgür Devrim; Öztürk, Yusuf; Demir, Özkay, Ü. (Turkiye Klinikleri, 2009)Hypericum perforatum L. is a plant, which has heen traditionally used for various ethnopharmacological purposes, including treatment of mental disorders. Reported pharmacological activities of the plant extract on central ... -
New antidepressant drug candidate: Hypericum montbretti extract
Can, Özgür Devrim; İsmail, İsmail Bilal; Öztürk, Yusuf; Öztürk, Nilgün; Potoğlu-Erkara, Ismuhan; Sagratini, Gianni; Maggi, Filippo (Taylor & Francis LTD, 2011)This study was designed to investigate possible antidepressant-like effects of the extract prepared from the flowers of Hypericum montbretti Spach. (Guttiferae, Clusiaceae). Phytochemical constituents of the methanolic ...