Yazar "Can, Özgür Devrim" için Fakülteler listeleme
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New pyrazoline derivatives and their antidepressant activity
Kaplancıklı, Zafer Asım; Özdemir, Ahmet; Turan, Gülhan; Altıntop, Mehlika Dilek; Can, Özgür Devrim (Elsevier France-Editions Scientifiques Medicales Elsevier, 2010)Some triazolo-pyrazoline derivatives were synthesized to investigate their potential antidepressant activities. The chemical structures of the compounds were elucidated by IR, NMR and FAB(+)-MS spectral data and elemental ... -
Opioid system mediated anti-nociceptive effect of agomelatine in mice
Kasap, Merve; Can, Özgür Devrim (Pergamon-Elsevier Science LTD, 2016)Aims: This study was planned to examine the antinociceptive efficacy of agomelatine against acute mechanical, thermal, and chemical nociceptive stimuli, as well as to determine the opioid receptor subtypes mediating these ... -
The Other Face of Diabetes Mellitus: Psychiatric and Neurodegenerative Complications: Review
Can, Özgür Devrim; Öztürk, Yusuf (Ortadogu Ad Pres & Publ Co, 2009)Diabetes mellitus (DM) is a metabolic disorder characterized by chronic hyperglycemia, which is caused by failure in insulin secretion and/or action and it triggers various acute and chronic complications in patients. The ... -
The other face of diabetes mellitus: Psychiatric and neurodegenerative complications: Review [Diabetes mellitus'un diger yüzü: Psikiyatrik ve nörodejeneratif komplikasyonlar]
Can, Özgür Devrim; Öztürk, Yusuf (Turkiye Klinikleri, 2009)Diabetes mellitus (DM) is a metabolic disorder characterized by chronic hyperglycemia, which is caused by failure in insulin secretion and/or action and it triggers various acute and chronic complications in patients. The ... -
Pharmacological and Toxicological Screening of Novel Benzimidazole-Morpholine Derivatives as Dual-Acting Inhibitors
Can, Nafiz Öncü; Çevik, Ulviye Acar; Sağlık, Begüm Nurpelin; Özkay, Yusuf; Atlı Eklioğlu, Özlem; Baysal, Merve; Can, Özgür Devrim (MDPI, 2017)The aim of this study was to investigate acetylcholinesterase (AChE), monoamine oxidase A (MAO-A), monoamine oxidase B (MAO-B), cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2) enzyme inhibitory, and antimicrobial ... -
Psychopharmacological profile of Chamomile (Matricaria recutita L.) essential oil in mice
Can, Özgür Devrim; Özkay, Ümide Demir; Kıyan, Hülya Tuba; Demirci, Betül (Elsevier GMBH, Urban & Fischer Verlag, 2012)In this study, the effect of Matricaria recutita L essential oil (MEO) on the central nervous system (CNS) of mice was investigated using some behavioral methods. Chemical profiling both by GC and GC-MS analyses of the ... -
Role of St. John'S Wort (Hypericum Perforatum L.) in the Management of Diabetes and Neurological Disorders
Öztürk, Yusuf; Can, Özgür Devrim; Demir-Özkay, Ümide (Apple Acad Press Inc, 2018)St. John's Wort (Hypericum perforatum L.) is a widely utilized antidepressant plant, which has been used as both therapeutic drug and over-the-counter (OTC) product in all around the world. There are many ethnomedical, ... -
Role of St. John’s wort (Hypericum perforatum L.) in the management of diabetes and neurological disorders
Öztürk, K, Y.; Can, Özgür Devrim; Demir-Özkay, Ümide (Apple Academic Press, 2018)2St. John’s Wort (Hypericum perforatum L.) is a widely utilized antidepressant plant, which has been used as both therapeutic drug and over-the-counter (OTC) product in all around the world. There are many ethnomedical, ... -
Synthesis and analgesic activity of some acetamide derivatives
Kaplancıklı, Zafer Asım; Altıntop, Mehlika Dilek; Turan, Gülhan; Özdemir, Ahmet; Can, Özgür Devrim (Informa Healthcare, 2012)In the present study, some acetamide derivatives were synthesized and their potential analgesic activities were investigated. N-(benzothiazol-2-yl)-2-[(1-substituted-1H-tetrazol-5-yl) thio] acetamide derivatives were ... -
Synthesis and analgesic effects of 2-(2-carboxyphenylsulfanyl)-N-(4-substitutedphenyl)acetamide derivatives
Özkay, Ümide Demir; Özkay, Yusuf; Can, Özgür Devrim (Springer Birkhauser, 2011)This present study was undertaken to synthesize and investigate possible analgesic activities of some 2-(2-carboxyphenylsulfanyl)-N-(4-substitutedphenyl)acetamide derivatives that were designed by combining an analgesic ... -
Synthesis and anti-nociceptive, anti-inflammatory activities of new aroyl propionic acid derivatives including N-acylhydrazone motif
Turan, Gülhan; Yurttaş, Leyla; Kaplancıklı, Zafer Asım; Can, Özgür Devrim; Özkay, Ümide Demir (Springer Birkhauser, 2015)In the present study, new 4-[4-[2-(2-(4-substituted benzylidene)hydrazinyl)-2-oxoethoxy]phenyl]-4-oxobutanoic acid derivatives were synthesized, and their anti-nociceptive and anti-inflammatory activities were investigated. ... -
Synthesis and Antidepressant Activity Profile of Some Novel Benzothiazole Derivatives
Özkay, Ümide Demir; Kaya, Ceren; Çevik, Ulviye Acar; Can, Özgür Devrim (MDPI, 2017)Within the scope of our new antidepressant drug development efforts, in this study, we synthesized eight novel benzothiazole derivatives 3a-3h. The chemical structures of the synthesized compounds were elucidated by ... -
Synthesis and antinociceptive activities of some novel benzimidazole-piperidine derivatives
Özkay, Ümide Demir; Can, Özgür Devrim; Turan, Nazlı; Kaya Çavuşoğlu, Betül (Scientific Technical Research Council Turkey-Tubitak, 2017)In this study, a series of benzimidazole-piperidine derivatives were synthesized with the objective of developing potent antinociceptive agents. Some 2-(4-substituted-phenyl) 1 [2 (piperidin-1-yBethyl]-1 H-benzimidazole ... -
Synthesis and antinociceptive activities of some pyrazoline derivatives
Kaplancıklı, Zafer Asım; Turan, Gülhan; Özdemir, Ahmet; Can, Özgür Devrim; Chevallet, Pierre (Elsevier France-Editions Scientifiques Medicales Elsevier, 2009)In the present study, some pyrazoline derivatives were synthesized to investigate their potential antinociceptive activities. 1-[(Benzoxazole/benzimidazole-2-yl)thioacetyl]pyrazoline derivatives were obtained by reacting ... -
Synthesis and Evaluation of New 1,3,4-Thiadiazole Derivatives as Antinociceptive Agents
Altıntop, Mehlika Dilek; Can, Özgür Devrim; Özkay, Ümide Demir; Kaplancıklı, Zafer Asım (MDPI AG, 2016)In the current work, new 1,3,4-thiadiazole derivatives were synthesized and investigated for their antinociceptive effects on nociceptive pathways of nervous system. The effects of these compounds against mechanical, thermal ... -
Synthesis and Evaluation of New 1,5-Diaryl-3-[4-(methyl-sulfonyl)phenyl]-4,5-dihydro-1H-pyrazole Derivatives as Potential Antidepressant Agents
Özdemir, Ahmet; Altıntop, Mehlika Dilek; Kaplancıklı, Zafer Asım; Can, Özgür Devrim; Özkay, Ümide Demir; Turan, Gülhan (MDPI, 2015)In an effort to develop potent antidepressant agents, new pyrazoline derivatives 2a-s were synthesized and evaluated for their antidepressant-like activity by tail suspension test (TST) and modified forced swimming test ... -
Synthesis of new 1-phenyl-2-(4-substituted-piperazin-1-yl)-propanol derivatives and evaluation of their antidepressant-like effects
Özkay, Ümide Demir; Yurttaş, Leyla; Özkay, Yusuf; Ucel, Umut İrfan; Can, Özgür Devrim; Öztürk, Yusuf (Pharmaceutical Soc Korea, 2013)In this study, we synthesized eight novel 1-phenyl-2-(4-substituted-piperazin-1-yl)-propanol derivatives and evaluated their antidepressant-like activities. The chemical structures of the synthesised compounds were elucidated ... -
Synthesis of Novel Benzazole Derivatives and Evaluation of Their Antidepressant-Like Activities with Possible Underlying Mechanisms
TokgÖz, Gamze; Özkay, Ümide Demir; Osmaniye, Derya; Yücel, Nazlı Turan; Can, Özgür Devrim; Kaplancıklı, Zafer Asım (MDPI, 2018)Novel benzazole derivative compounds 4a-4h were obtained by the reaction of corresponding 2-(benzazol-2-ylthio)acetohydrazide and appropriate 4-substituted benzaldehydes. The chemical structures of the synthesized compounds ... -
Synthesis of Some Novel Thiadiazole Derivative Compounds and Screening Their Antidepressant-Like Activities
Can, Nafiz Öncü; Can, Özgür Devrim; Osmaniye, Derya; Özkay, Ümide Demir (MDPI, 2018)Novel thiadiazole derivatives were synthesized through the reaction of acetylated 2-aminothiadiazole and piperazine derivatives. The chemical structures of the compounds were clarified by Infrared Spectroscopy (IR), H-1 ... -
Synthesis of Some Thiadiazole Derivatives as New Anticonvulsant Agents
Kaplancıklı, Zafer Asım; Altıntop, Mehlika Dilek; Özdemir, Ahmet; Turan, Gülhan; Can, Özgür Devrim (Elsevier Science BV, 2011)…