Kurum Yazarı "Kutlu, Hatice Mehtap" Makale Koleksiyonu İçin Listeleme
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Examining impacts of ceranib-2 on the proliferation, morphology and ultrastructure of human breast cancer cells
Vejselova, Djanan; Kutlu, Hatice Mehtap; Kuş, Gökhan (Springer, 2016)Acid ceramidases are enzymes with a vital role in metabolizing ceramide to sphingosine-1-phosphate that is an antiproliferative metabolite in the ceramide pathway. Inhibition of exogenous ceramides with ceramidase inhibitors ... -
Histopathological alterations and cadmium accumulation in the liver and gills of Aphanius chantrei (Gaillard, 1895) (Cyprinodontiformes: Cyprinodontidae)
Kutlu, Hatice Mehtap; Kılıç, Volkan (2009)The aim of the present study was to investigate the toxic effects of cadmium (Cd) in the liver and gills of Aphanius chantrei at the histopathological level. Fish were exposed to the acute concentration of Cd (5.5 mg/L) ... -
HISTOPATHOLOGICAL ALTERATIONS AND CADMIUM ACCUMULATION IN THE LIVER AND GILLS OF Aphanius chantrei (Gaillard, 1895) (CYPRINODONTIFORMES: CYPRINODONTIDAE)
Kutlu, Hatice Mehtap; Kılıç, Volkan (Parlar Scientific Publications (PSP), 2009)The aim of the present study was to investigate the toxic effects of cadmium (Cd) in the liver and gills of Aphanius chantrei at the histopathological level. Fish were exposed to the acute concentration of Cd (5.5 mg/L) ... -
The Impact of Caffeic Acid Loaded Solid Lipid Nanoparticles on Cancer Treatment
Kutlu, Hatice Mehtap; Genç, Lütfi; Güney, Gamze (Bentham Science Publ LTD, 2013)In an attempt to develop caffeic acid for drug delivery, caffeic acid-loaded solid lipid nanoparticles (CA-SLNs) were constructed, and were characterized to determine their properties followed by their evaluation for in ... -
Inhibitory effects of salicylic acid on A549 human lung adenocarcinoma cell viability
Vejselova, Djanan; Kutlu, Hatice Mehtap (Tubitak Scientific & Technical Research Council Turkey, 2015)Antiinflammatory drugs, such as salicylic acid and its metabolite acetylsalicylic acid, have been singled out as apoptosis-inducing agents with antitumoral activity. In addition, they reduce the risk of some cancers via ... -
Investigation of mitochondrial DNA of some West Anatolian Gammarus species (Crustacea: Amphipoda) by PCR-RAPD techniques [Bazi{dotless} Bati{dotless} Anadolu Gammarus (Crustacea: Amphipoda) türlerinin mitokondrial DNA'lari{dotless}ni{dotless}n PZR-RAPD teknigi ile incelenmesi]
Aim: Mitochondrial DNA is widely used in order to estimate the amount of genetic variability within and between different species, because of its conserved structure and organization. Random Amplified Polymorphic DNA ... -
Isolation and identification of selenite reducing archaea from Tuz (salt) Lake In Turkey
Güven, Kıymet; Mutlu, Mehmet Burçin; Cirpan, Ceyhun; Kutlu, Hatice Mehtap (Wiley-Blackwell, 2013)In this study, Tuz lake brine samples were investigated for isolation and identification of selenite resistant halophilic prokaryotes. Among the 20 strains of extremely halophilic Bacteria and Archaea, a Gram negative rod ... -
Lead toxicity and biochemical characterization of delta-ALAD on endemic prawn, Palaemonetes turcorum
Ciğerci, İbrahim Hakkı; Konuk, Muhsin; Kutlu, Hatice Mehtap (Foundation Environmental Protection & Research-Fepr, 2010)The aim of this studuy was to determine the toxic effect of lead (Pb) on Palaemonetes turcorum, which is endemic to Turkey, in vivo and its inhibitory effect on its delta-Aminolevulinic acid dehydratase (ALAD; E.C.4.2.1.24) ... -
Melatonin induces antiproliferative activity through modulation of apoptotic pathway in H-ras oncogene transformed 5RP7 cells
Kaplan, Ayşe; Çiftçi, Gülsen Akalın; Kutlu, Hatice Mehtap (Tubitak Scientific & Technical Research Council Turkey, 2015)In the present study, cytotoxic and apoptotic effects of melatonin were investigated on H-ras oncogene transformed rat embryo fibroblast 5RP7 cells. Melatonin inhibited cell growth and induced apoptosis in 5RP7 cells. We ... -
Mutagenic activities of ten imidazole derivatives in Salmonella typhimurium
Aydoğan, Gözde; Kutlu, Hatice Mehtap (Springer, 2007)Ten imidazole derivatives were tested for mutagenicity in Salmonella typhimurium strains TA98 and TA100 both in the absence and presence of metabolic activation by the microsomal fraction S9 mix. In a general manner, ... -
Mutagenic potential of water from the Tuz Lake, Turkey
Güven, Kıymet; Kutlu, Hatice Mehtap; Aydoğan Kılıç, Gözde; Mutlu, Mehmet Burçin (Parlar Scientific Publications (PSP), 2008)The mutagenic potential of water samples from the Tuz Lake, Turkey was examined by applying the Salmonella mutagenicity assay (Ames test), using TA 98 and TA 100 strains without metabolic activation. XAD 4 and XAD 16 column ... -
Mutagenicity analysis of water samples from Seydisuyu (Kirka, Turkey) stream under the influence of boron production complex
Kutlu, Hatice Mehtap; Aydoğan, Gözde; Mumcu, Emel (Pergamon-Elsevier Science LTD, 2007)Kirka region in Turkey is naturally high in boron content. There is also a boron production complex in our study area. Although boron was found to be neither genotoxic nor carcinogenic, mutagenicity of boron can still be ... -
Nitrate reduction in Haloferax alexandrinus: the case of assimilatory nitrate reductase
Kılıç, Volkan; Aydoğan-Kılıc, G.; Kutlu, Hatice Mehtap; Maria Martinez-Espinosa, Rosa (Springer Japan Kk, 2017)Haloferax alexandrinus Strain TM JCM 10717(T) = IFO 16590(T) is an extreme halophilic archaeon able to produce significant amounts of canthaxanthin. Its genome sequence has been analysed in this work using bioinformatics ... -
Potential protective effect of resveratrol on acoustic trauma: electron microscopy study
Hanci, D.; Ulusoy, S.; Acar, M.; Burukoğlu, D.; Kutlu, Hatice Mehtap; Muluk, Nuray Bayar; Cingi, Cemal (Verduci Publisher, 2016)OBJECTIVE: To investigate the potential preventive effect of resveratrol in rats exposed to acoustic trauma (AT). MATERIALS AND METHODS: In this experimental study, Wistar albino rats were divided into three groups: Group ... -
The Potential Protective Effects of 2-aminoethyl Diphenylborinate against Inner Ear Acoustic Trauma: Experimental Study Using Transmission and Scanning Electron Microscopy
Kaymakci, Mustafa; Acar, Mustafa; Burukoğlu, Dilek; Kutlu, Hatice Mehtap; Shojaolsadati, Paria; Cingi, Cemal; Muluk, Nuray Bayar (Aves, 2015)OBJECTIVE: In this prospective experimental study, we investigated the preventive effects of 2-aminoethyl diphenylborinate (2-APB) in rats exposed to acoustic trauma (AT). Light microscopic, transmission electron microscopic ... -
Potential Recruiting and Hepatoprotective Effects of Ellagic Acid in D-Galactosamine-Induced Liver Damage in Rats
Cengiz, Mustafa; Ali, Jama Hussein; Kutlu, Hatice Mehtap; Vejselova, Djanan; Ayhanci, Adnan (Zoological Soc Pakistan, 2017)The present study aims to investigate the therapeutic and protective effects of ellagic acid (EA) on the toxicity of the liver induced by D-Galactosamine (D-GaIN) in rats. With this in mind, the rats were categorized into ... -
Potential therapeutic effects of silymarin and silymarin-loaded solid lipid nanoparticles on experimental kidney damage in BALB/c mice: biochemical and histopathological evaluation
Cengiz, Mustafa; Ayhanci, Adnan; Kutlu, Hatice Mehtap; Musmul, Ahmet (Tubitak Scientific & Technical Research Council Turkey, 2016)Silymarin (Sm) is widely used in treating diseases that affect organs such as the liver, kidney, and gallbladder thanks to its antioxidative, renoprotective, antihepatotoxic, and anticarcinogenic properties. However, this ... -
Preparation and characterization of ascorbic acid loaded solid lipid nanoparticles and investigation of their apoptotic effects
Güney, Gamze; Kutlu, Hatice Mehtap; Genç, Lütfi (Elsevier Science BV, 2014)In this paper, ascorbic acid (Vitamin C, AA) known as an antioxidant was successfully incorporated in solid lipid nanoparticles (SLNs) by hot homogenization and efficient delivery of AA to cancer cells. The obtained SLN ... -
Promising anti-growth effects of palladium(II) saccharinate complex of terpyridine by inducing apoptosis on transformed fibroblasts in vitro
Coşkun, Melis Debreli; Arı, Ferda; Oral, Arzu Yılmaztepe; Sarımahmut, Mehmet; Kutlu, Hatice Mehtap; Yılmaz, Veysel T.; Ulukaya, Engin (Pergamon-Elsevier Science LTD, 2013)Fibrosarcoma is one of the fatal cancer types and there is still not satisfactory success in its treatment despite new drugs. Therefore, the search for a new compound has been going on. It is currently known that some ...