Kurum Yazarı "Koparal, Ayşe Tansu" Makale Koleksiyonu İçin Listeleme
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Angiogenesis Inhibition by A Lichen Compound Olivetoric Acid
Koparal, Ayşe Tansu; Ulus, Gönül; Zeytinoğlu, Melih; Tay, Turgay; Türk, Ayşen Özdemir (Wiley-Blackwell, 2010)Lichens have been used in folk medicine for centuries and are symbiotic organisms of fungi and algae that produce unique secondary metabolites. Olivetoric acid is one of these secondary metabolites. In the present studs ... -
The anti-angiogenic activity of Artemisia herba-alba's essential oil and its relation with the harvest period
Jaouadi, I.; Koparal, Ayşe Tansu; Bostancıoğlu, Rakibe Beklem; Yakoubi, M. T.; El, Gazzah, M. (Southern Cross Publishing and Printing Pty Ltd, 2014)Artemisia herba-alba is widely used in traditional medicine to treat diabetes, bronchitis, diarrhoea, hypertension and neuralgias. The aim of this study is to investigate the essential oil extracted from the aerial part ... -
Anti-angiogenic and antiproliferative properties of the lichen substances (-)-usnic acid and vulpinic acid
Koparal, Ayşe Tansu (Walter De Gruyter GMBH, 2015)The anti-proliferative activities of the lichen substances (-)-usnic acid and vulpinic acid on the viability of HepG2 hepatocarcinoma cells, NS20Y neuroblastoma cells and HUVEC endothelial cells were studied by the MTT ... -
The anti-angiogenic potential of (+/-) gossypol in comparison to suramin
Ulus, Gönül; Koparal, Ayşe Tansu; Baysal, Kemal; Yetik Anacak, Günay; Yavaşoğlu, N. Ülkü Karabay (Springer, 2018)Cotton, a staple fiber that grows around the seeds of the cotton plants (Gossypium), is produced throughout the world, and its by products, such as cotton fibers, cotton-seed oil, and cottonseed proteins, have a variety ... -
Anti-lung Cancer and Anti-angiogenic Activities of New Designed Boronated Phenylalanine Metal Complexes
Varol, Mehmet; Koparal, Ayşe Tansu; Benkli, Kadriye; Bostancıoğlu, Rakibe Beklem (Bentham Science Publ LTD, 2018)Background: Drug design and discovery studies still remain of great importance in the search for more convenient chemotherapeutic to avoid the drug resistance, systemic toxicity or the long-term side effects. Objective: A ... -
Assessment of anti-angiogenic and anti-tumoral potentials of Origanum onites L. essential oil
Bostancıoğlu, R. Beklem; Kürkçüoğlu, Mine; Başer, K. Hüsnü Can; Koparal, Ayşe Tansu (Pergamon-Elsevier Science LTD, 2012)Medicinal plants and culinary herbs with anti-angiogenic and little toxicity properties have gained importance. Non-toxic anti-angiogenic phytochemicals are useful in combating cancer by preventing the formation of new ... -
Biocompatibility of designed MicNo-ZnO particles: Cytotoxicity, genotoxicity and phototoxicity in human skin keratinocyte cells
Genç, Hatice; Barutca, Banu; Koparal, Ayşe Tansu; Özogut, Uğurcan; Şahin, Yücel; Suvacı, Ender (Pergamon-Elsevier Science LTD, 2018)Recently, designed platelet shaped micron particles that are composed of nano primary particles, called MicNo (= Micron + naNo) particles, have been developed to exploit the benefits of nano size, while removing the adverse ... -
Cryptic fragment ?4 LG4-5 derived from laminin ?4 chain inhibits de novo adipogenesis by modulating the effect of fibroblast growth factor-2
Yamanaka, Hiroaki; Goto, Chie; Tajima, Rie; Koparal, Ayşe Tansu; Kobori, Masato; Ohki, Yuji; Kitagawa, Y. (2008)Cleavage of the extracellular matrix (ECM) by proteolysis unmasks cryptic sites and generates novel fragments with biological activities functionally distinct from those of the intact ECM molecule. The laminin G-like (LG)4-5 ... -
Cryptic fragment alpha 4 LG4-5 derived from laminin alpha 4 chain inhibits de novo adipogenesis by modulating the effect of fibroblast growth factor-2
Yamashita, Hironobu; Goto, Chie; Tajima, Rie; Koparal, Ayşe Tansu; Kobori, Masato; Ohki, Yuji; Kitagawa, Yasuo (Blackwell Publishing, 2008)Cleavage of the extracellular matrix (ECM) by proteolysis unmasks cryptic sites and generates novel fragments with biological activities functionally distinct from those of the intact ECM molecule. The laminin G-like (LG)4-5 ... -
Cytotoxic Effect of Eudesmanolides Isolated from Flowers of Tanacetum vulgare ssp siculum
Rosselli, Sergio; Bruno, Maurizio; Raimondo, Francesco Maria; Spadaro, Vivienne; Varol, Mehmet; Koparal, Ayşe Tansu; Maggio, Antonella (MDPI, 2012)A phytochemical analysis of the dichloromethane extract from the flowers of a subspecies of Tanacetum vulgare growing in Sicily was carried out. Five known sesquiterpene lactones with the eudesmane skeleton have been ... -
Cytotoxic effects of various lactic acid bacteria on Caco-2 cells
Er, Sevda; Koparal, Ayşe Tansu; Kıvanç, Merih (Tubitak Scientific & Technical Research Council Turkey, 2015)Probiotics are live microbial food supplements that can be considered a functional food. They benefit the health of a host animal by maintaining their intestinal microbial balance. Most probiotic microorganisms are lactic ... -
Design and synthesis of novel organometallic complexes using boronated phenylalanine derivatives as potential anticancer agents
Varol, Mehmet; Benkli, Kadriye; Koparal, Ayşe Tansu; Bostancıoğlu, Rakibe Beklem (Taylor & Francis LTD, 2019)Drug design and discovery studies are important because of the prevalence of diseases without available medical cures. New anticancer agents are particularly urgent because of the high mortality rate associated with cancer. ... -
Differential effect of green tea catechins on three endothelial cell clones isolated from rat adipose tissue and on human umbilical vein endothelial cells
Koparal, Ayşe Tansu; Yamaguchi, H; Omae, K; Torii, S; Kitagawa, Y (Springer, 2004)By single colony isolation from the cells in stromal vascular fraction (SVF) dispersed from rat adipose tissues, we isolated three independent clones with different proliferation potential. All clones showed cobblestone-like ... -
Evaluation of Multifunctional Hybrid Analogs for Stilbenes, Chalcones and Flavanones
Çağır, Ali; Odaci, Burcu; Varol, Mehmet; Akcok, İsmail; Okur, Özgür; Koparal, Ayşe Tansu (Bentham Science Publ LTD, 2017)Aims: In this study, discovery of novel anticancer agents acting by more than one mechanism was aimed. Method: For this purpose, eleven previously synthesized simple-stilbene, chalcone, flavanone derivatives and 31 novel ... -
Evaluation of the sunscreen lichen substances usnic acid and atranorin
Varol, Mehmet; Tay, Turgay; Candan, Mehmet; Türk, Ayşen Özdemir; Koparal, Ayşe Tansu (Inst Histol Embriol-Conicet, 2015)Usnic acid and atranorin are known as both sunscreen substances in natural lichen population and cytotoxic substances on human cell lines. Both substances were isolated from the acetone extracts of Cladonia foliacea and ... -
Gold(III) compounds-mediated inhibition of lung cancer cell proliferation
Bostancıoğlu, R. Beklem; Kaya, Murat; Koparal, Ayşe Tansu; Benkli, Kadriye (Lippincott Williams & Wilkins, 2016)Research on chemotherapeutics for lung cancer is crucial for designing a new therapeutic strategy against malignant lung tumors. Although radiotherapy and chemotherapy, which are not selective for cancer cells and exert ... -
The in vitro assessment of dipyridophenazine complexes in H-ras oncogene transformed rat embryo fibroblast 5RP7 cell line
Kaplan, Ayşe; Benkli, Kadriye; Koparal, Ayşe Tansu (Springer, 2018)Purpose The aim of this study is to detect apoptotic and cytotoxic/antiproliferative effects of a ligand substance and its metal derivatives. The substances were investigated by using an h-ras oncogene transformed rat ... -
In vitro evaluation of combination of EGCG and Erlotinib with classical chemotherapeutics on JAR cells
Telli, Elçin; Genç, Hatice; Tasa, Burcugül Altuğ; Özalp, S. Sinan; Koparal, Ayşe Tansu (Springer, 2017)Gestational Trophoblastic Neoplasia (GTN) is a term used for a group of malignant gynecological tumors including choriocarcinoma. Low-risk neoplasias can be cured using single agents Methotrexate (MTX) and actinomycin-D(ACD), ... -
Induction of apoptosis and inhibition of cell proliferation by the cyclooxgenase enzyme blocker nimesulide in the Ishikawa endometrial cancer cell line
Özalp, S. Sinan; Eren, Ceren Yıldız; Bostancıoğlu, Rakibe Beklem; Koparal, Ayşe Tansu (Elsevier Science BV, 2012)Objectives: Endometrial cancer remains a leading cause of death in women and therefore the development of new therapies is essential. The present study evaluated the effects of nimesulide alone, cisplatin alone, and ... -
Investigation of the pharmacological profiles of dinuclear metal complexes as novel, potent and selective cytotoxic agents against leas-transformed cells
Bostancıoğlu, R. Beklem; Koparal, Ayşe Tansu; Benkli, Kadriye (Elsevier Science BV, 2014)Around the world scientists try to design successful cures against still incurable diseases, especially cancers. New targets for prevention and new agents for therapy need to be identified. We synthesized novel metal ...