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dc.contributor.authorAda, Servet
dc.contributor.authorHanci, Deniz
dc.contributor.authorUlusoy, Seçkin
dc.contributor.authorVejselova, Djanan
dc.contributor.authorBurukoğlu, Dilek
dc.contributor.authorMuluk, Nuray Bayar
dc.contributor.authorCingi, Cemal
dc.date.accessioned2019-10-20T08:00:49Z
dc.date.available2019-10-20T08:00:49Z
dc.date.issued2017
dc.identifier.issn1899-5276
dc.identifier.urihttps://dx.doi.org/10.17219/acem/64332
dc.identifier.urihttps://hdl.handle.net/11421/16185
dc.descriptionWOS: 000418447200001en_US
dc.descriptionPubMed ID: 29068588en_US
dc.description.abstractBackground. Oxidative stress has been associated with pathological processes involved in acoustic trauma. Objectives. In this prospective experimental study, we investigated the potential preventive effect of N-acetyl cysteine (NAC) in rats exposed to acoustic trauma (AT). Light microscopic and scanning electron microscopic (SEM) evaluations were performed. Material and methods. Healthy Wistar albino rats (n = 18) were divided into 3 groups: group 1 (control group, n = 6), group 2 (acoustic trauma group, n = 6), and group 3 (AT+NAC group, n = 6). The rats in group 2 were exposed to AT. The rats in group 3 received NAC at a dose of 100 mg/kg/day by gavage for 7 days, and then 10 min after the 7th-day dose, they were exposed to AT. Results. From light and scanning electron microscopy evaluations in the control group, the cochlear structure and epithelium were normal. In group 2 (AT group), extensive hair cell loss was observed in the cochlea by light microscopy evaluation. In the SEM evaluation, various epithelial damage and loss of stereocilia were also observed. In group 3 (AT+ NAC group), decreased damage with preserved cochlear structures was seen by light microscopy. In the SEM evaluation, although stereocilia loss was also seen, nearly normal cell structures and vertical and symmetrical alignment of stereocilia structures were observed compared to the AT group. Conclusions. NAC reduced cochlear damage due to acoustic trauma. Because NAC has antioxidant capacity, AT mat have caused an increase in free radicals and death of outer hair cells. NAC is an antioxidant agent and it prevented cochlear damage due to AT in rats.en_US
dc.description.sponsorshipContinuous Education and Scientific Research Associationen_US
dc.description.sponsorshipWith the exception of data collection, the preparation of this paper, including design and planning, was supported by the Continuous Education and Scientific Research Association. Only scientific support was provided; no grant or funding was received.en_US
dc.language.isoengen_US
dc.publisherWroclaw Medical Universityen_US
dc.relation.isversionof10.17219/acem/64332en_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectN-Acetyl Cysteine (Nac)en_US
dc.subjectAcoustic Trauma (At)en_US
dc.subjectLight Microscopyen_US
dc.subjectScanning Electron Microscopy (Sem)en_US
dc.titlePotential protective effect of N-acetyl cysteine in acoustic trauma: An experimental study using scanning electron microscopyen_US
dc.typearticleen_US
dc.relation.journalAdvances in Clinical and Experimental Medicineen_US
dc.contributor.departmentAnadolu Üniversitesi, Fen Fakültesi, Biyoloji Bölümüen_US
dc.identifier.volume26en_US
dc.identifier.issue6en_US
dc.identifier.startpage893en_US
dc.identifier.endpage897en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US


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