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dc.contributor.authorÖztetik, Elif
dc.date.accessioned2019-10-20T08:00:58Z
dc.date.available2019-10-20T08:00:58Z
dc.date.issued2012
dc.identifier.issn1300-0861
dc.identifier.issn1308-2817
dc.identifier.urihttps://dx.doi.org/10.1501/Vetfak_0000002515
dc.identifier.urihttps://hdl.handle.net/11421/16223
dc.descriptionWOS: 000302203200010en_US
dc.description.abstractThe primary aim of the study was to test the influences of thapsigargicin in releasing Ca2+ from the intracellular Ca2+ stores and comparing it with the effects of thapsigargin. In this study, the effect of tumour promoter thapsigargicin on intracellular Ca2+ has been described. Therefore, rat liver endoplasmic reticulum subcellular fractions (microsomes) were employed and Ca2+ movements measured by spectrofluorimeter. Fluo-3 studies were used to follow Ca2+ release in experiments with microsomes. When results are evaluated, it has been concluded that like thapsigargin, thapsigargicin has the ability of discharging the intracellular Ca2+ stores, increasing the intracellular free Ca2+ concentration ([Ca2+]i) and being a potent and specific inhibitor of the ER Ca2+-ATPase.en_US
dc.description.sponsorshipTurkish Ministry of National Education (MEB)en_US
dc.description.sponsorshipAuthor is grateful to Emeritus Professor Alan P. Dawson for his helpful advices and discussions. During this study, author was supported by the bursary from Turkish Ministry of National Education (MEB).en_US
dc.language.isoengen_US
dc.publisherAnkara University Pressen_US
dc.relation.isversionof10.1501/Vetfak_0000002515en_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCa2+ Releaseen_US
dc.subjectIntracellular Storesen_US
dc.subjectSerca Atpasesen_US
dc.subjectSpectroscopyen_US
dc.subjectThapsigargin (Tg)en_US
dc.subjectThapsigargicin (Tgc)en_US
dc.titleA study of calcium release from rat liver microsomes by thapsigargicin inductionen_US
dc.typearticleen_US
dc.relation.journalAnkara Universitesi Veteriner Fakültesi Dergisien_US
dc.contributor.departmentAnadolu Üniversitesi, Fen Fakültesi, Biyoloji Bölümüen_US
dc.identifier.volume59en_US
dc.identifier.issue2en_US
dc.identifier.startpage135en_US
dc.identifier.endpage140en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US


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