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dc.contributor.authorKhachatryan, V.
dc.contributor.authorSirunyan, A. M.
dc.contributor.authorTumasyan, A.
dc.contributor.authorAdam, W.
dc.contributor.authorBergauer, T.
dc.contributor.authorDragicevic, M.
dc.contributor.authorCollaboration
dc.date.accessioned2019-10-20T09:31:06Z
dc.date.available2019-10-20T09:31:06Z
dc.date.issued2013
dc.identifier.issn0020-8868
dc.identifier.urihttps://dx.doi.org/10.9738/CC130.2
dc.identifier.urihttps://hdl.handle.net/11421/17593
dc.description.abstractThe aim of the present study was to investigate the effect of hyperbaric oxygen therapy (HBOT) on colon anastomosis after chemoradiotherapy (CRT). Sixty female Wistar- Albino rats were divided into 5 groups and underwent left colon resection and end-toend anastomosis. CRT simulation was performed on 2 sham groups before the anastomosis, and 1 of these groups was administered additional postoperative HBOT. Two groups were administered CRT before the anastomosis, and 1 of them received additional postoperative HBOT. On postoperative day 5, all groups underwent relaparotomy; burst pressure was measured and samples were obtained for histopathologic and biochemical analysis. There was a significant weight loss in the CRT groups and postoperative HBOT had an improving effect. Significantly decreased burst pressure values increased up to the levels of the controls after HBOT. Hydroxyproline levels were elevated in all groups compared to the control group. Hydroxyproline levels decreased with HBOT after CRT. No significant difference was observed between the groups regarding fibrosis formation at the anastomosis site. However, regression was observed in fibrosis in the group receiving HBOT after CRT. Preoperative CRT affected anastomosis and wound healing unfavorably. These unfavorable effects were alleviated by postoperative HBOT. HBOT improved the mechanical and biochemical parameters of colon anastomosis in rats.en_US
dc.language.isoengen_US
dc.publisherInternational College of Surgeonsen_US
dc.relation.isversionof10.9738/CC130.2en_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAnastomosis; Burst pressure; Chemoradiotherapy; Hyperbaric oxygen; Raten_US
dc.titleThe effects of hyperbaric oxygen therapy on experimental colon anastomosis after preoperative chemoradiotherapyen_US
dc.typearticleen_US
dc.relation.journalInternational Surgeryen_US
dc.contributor.departmentAnadolu Üniversitesi, Fen Fakültesi, Fizik Bölümüen_US
dc.identifier.volume98en_US
dc.identifier.issue1en_US
dc.identifier.startpage33en_US
dc.identifier.endpage42en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US


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