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dc.contributor.authorEskiler, G. Güney
dc.contributor.authorCecener, G.
dc.contributor.authorDikmen, G.
dc.contributor.authorKani, İbrahim
dc.contributor.authorEgeli, U.
dc.contributor.authorTunca, B.
dc.date.accessioned2019-10-20T14:27:48Z
dc.date.available2019-10-20T14:27:48Z
dc.date.issued2016
dc.identifier.issn0265-2048
dc.identifier.issn1464-5246
dc.identifier.urihttps://dx.doi.org/10.1080/02652048.2016.1228704
dc.identifier.urihttps://hdl.handle.net/11421/17831
dc.descriptionWOS: 000388747400010en_US
dc.description.abstractManganese (Mn)-based complexes have been drawing attention due to the fact that they are more effective than other metal complexes. However, the use of Mn(II)-based complexes in medicine remains limited because of certain side effects. The aim of this study was to investigate the cytotoxic and apoptotic effects of a novel Mn(II) complex [Mn-2(mu-(C6H5)(2)CHCOO)(2)(bipy)(4)](bipy)(ClO4)(2) and Mn(II) complex loaded solid lipid nanoparticles (SLNs) on MCF-7 and HUVEC control cells. The average diameter of Mn(II) complex was about 1120 +/- 2.43nm, while the average particle size of Mn(II) complex-SLNs was approximate to 340 +/- 2.27nm. The cytotoxic effects of Mn(II) complex and Mn(II)-SLNs were 86.8 and 66.4%, respectively (p<.05). Additionally, both Mn(II) complex (39.25%) and Mn(II)-SLNs (38.05%) induced apoptosis and increased the arrest of G(0)/G(1) phase. However, Mn(II) complex exerted toxic effects on the HUVEC control cell (63.4%), whereas no toxic effects was observed when treated with Mn(II)-SLNs at 150M. As a consequence, SLNs might be potentially used for metal-based complexes in the treatment of cancer due to reducing size and toxic effects of metal-based complexes.en_US
dc.description.sponsorshipScientific Research Projects Foundation of the Uludag University of Turkey [OUAP(T)-2014/30]; Anadolu University [1505F249]en_US
dc.description.sponsorshipThis study was supported by a grant from the Scientific Research Projects Foundation of the Uludag University of Turkey [Project No. OUAP(T)-2014/30] and Anadolu University Research Fund [Grant No. 1505F249].en_US
dc.language.isoengen_US
dc.publisherTaylor & Francis LTDen_US
dc.relation.isversionof10.1080/02652048.2016.1228704en_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectMetal-Based Ligandsen_US
dc.subjectMn(Ii) Complexen_US
dc.subject2,2 '-Bipyridineen_US
dc.subjectDrug Delivery Systemsen_US
dc.subjectSolid Lipid Nanoparticles (Slns)en_US
dc.subjectCanceren_US
dc.titleA novel [Mn-2(mu-(C6H5)(2)CHCOO)(2)(bipy)(4)](bipy)(ClO4)(2) complex loaded solid lipid nanoparticles: synthesis, characterization and in vitro cytotoxicity on MCF-7 breast cancer cellsen_US
dc.typearticleen_US
dc.relation.journalJournal of Microencapsulationen_US
dc.contributor.departmentAnadolu Üniversitesi, Fen Fakültesi, Kimya Bölümüen_US
dc.identifier.volume33en_US
dc.identifier.issue6en_US
dc.identifier.startpage575en_US
dc.identifier.endpage584en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US]
dc.contributor.institutionauthorKani, İbrahim


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