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dc.contributor.authorAvan, İlker
dc.contributor.authorGüven, Alaattin
dc.contributor.authorGüven, Kıymet
dc.date.accessioned2019-10-20T14:27:51Z
dc.date.available2019-10-20T14:27:51Z
dc.date.issued2013
dc.identifier.issn1300-0527
dc.identifier.urihttps://hdl.handle.net/11421/17875
dc.description.abstractSynthesis and in vitro antimicrobial activities are reported for a series of 1,3,5-substituted 4-oxo-3,4-dihydro- 5H -pyridazino[4,5- b]indole derivatives. Corresponding pyridazino[4,5- b]indoles were prepared from ethyl 3-formyl-1Hindole- 2-carboxylate precursors and the functional group in question was installed with hydrazine and its derivatives. The purity and primary structures of pyridazino[4,5- b]indole were confirmed by IR, 1H NMR, and 13C NMR spectroscopy and elemental analyses. All of the indoles were tested for in vitro antimicrobial activity against 8 isolates of bacteria and a fungus including Staphylococcus aureus NRRL B-767, Escherichia coli ATCC 25922, Pseudomonas aeruginosa ATCC 27853, Proteus vulgaris NRRL-B123, Salmonella typhimurium NRRL B-4420, Bacillus subtilis NRRL 744, Listeria monocytogenes ATCC 7644, and Candida albicans by using broth microdilution test. All of the isolates showed moderate sensitivity against tested indoles and B. subtilis NRRL 744 was the most sensitiveen_US
dc.language.isoengen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subject-Carbolineen_US
dc.subjectAntimicrobial Activityen_US
dc.subjectIndoleen_US
dc.subjectPyridazino[4-5- B]Indoleen_US
dc.titleSynthesis and antimicrobial investigation of some 5H-pyridazino[4,5-b] indolesen_US
dc.typearticleen_US
dc.relation.journalTurkish Journal of Chemistryen_US
dc.contributor.departmentAnadolu Üniversitesi, Fen Fakültesi, Kimya Bölümüen_US
dc.identifier.volume37en_US
dc.identifier.issue2en_US
dc.identifier.startpage271en_US
dc.identifier.endpage291en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US]
dc.contributor.institutionauthorGüven, Alaattin
dc.contributor.institutionauthorGüven, Kıymet


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