Stereoselective and regioselective synthesis of NN-substituted methyl 2-((azolyl)methyl)-3-arylacrylates from Baylis-Hillman acetates

Abstract

N -Substituted methyl 2-((azolyl)methyl)-3-arylacrylates were synthesized stereo- and regioselectively with one-pot reaction between Baylis–Hillman acetates and a suitable acylazole in the presence of K2 CO3 as a base catalyst. The targeted N -substituted azole acrylates were efficiently obtained in good yields (39%–89%).

N -Substituted methyl 2-((azolyl)methyl)-3-arylacrylates were synthesized stereo- and regioselectively with one-pot reaction between Baylis–Hillman acetates and a suitable acylazole in the presence of K2 CO3 as a base catalyst. The targeted N -substituted azole acrylates were efficiently obtained in good yields (39%–89%).