Konu "Cytotoxicity" için Eczacılık Fakültesi listeleme
Toplam kayıt 62, listelenen: 1-20
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Antibacterial profiling of abietane-type diterpenoids
(Pergamon-Elsevier Science LTD, 2017)Abietic and dehydroabietic acid are interesting diterpenes with a highly diverse repertoire of associated bioactivities. They have, among others, shown antibacterial and antifungal activity, potentially valuable in the ... -
Antimicrobial and Cytotoxic Evaluation of New Quinazoline Derivatives
(Natural Products Inc, 2016)The synthesis of nine new quinazoline derivatives (2a-21) and evaluation of their antimicrobial and cytotoxic activities were aims of the present work. For the synthesis of the compounds, 2-chloro-6,7-dimethoxyquinazolin-4-amine ... -
Bioassay-Guided Investigation of Two Monarda Essential Oils as Repellents of Yellow Fever Mosquito Aedes aegypti
(American Chemical Society, 2013)As part of an ongoing research program to identify active mosquito repellents, Monarda bradburiana Beck and Monarda fistulosa L. essential oils showed good repellent activity with minimum effective dosages (MED) of 0.055 ... -
Biotransformation of abietic acid by fungi and biological evaluation of its metabolites
(Elsevier Sci LTD, 2017)Biotransformation of abietic acid was carried out initially using 28 different microbial strains. Among the evaluated, Mucor ramannianus produced a known metabolite namely 2 alpha-hydroxy-dehydroabietic acid whereas ... -
Cytotoxic and apoptotic effects of endemic Centaurea fenzlii Reichardt on the MCF-7 breast cancer cell line
(Tubitak Scientific & Technical Research Council Turkey, 2017)The main purpose of this study was to analyze the cytotoxic activity of an extract obtained from Centaurea fenzlii Reichardt, and the fractions eluted from this extract, in breast cancer cells. After isolation and structural ... -
Cytotoxic effects of some perimidine derivatives on F2408 and 5Rp7 cell lines
(2008)In this study twenty perimidine derivatives were prepared in order to seek their cytotoxic and antiproliferative effects on normal rat embryo fibroblast (F2408) and carcinogenic rat embryo fibroblast (5RP7) cell lines. ... -
Cytotoxic, Antiproliferative and Apoptotic Effects of New Benzimidazole Derivatives on A549 Lung Carcinoma and C6 Glioma Cell Lines
(Bentham Science Publ LTD, 2015)Benzimidazole ring is a versatile structure which has been extensively utilized in medicinal chemistry. Since we are working on 1,2-disubstutited benzimidazoles, we have reported new antitumor active derivatives. As a ... -
Cytotoxic, Antiproliferative and Apoptotic Effects of Perillyl Alcohol and Its Biotransformation Metabolite on A549 and HepG2 Cancer Cell Lines
(Bentham Science Publ LTD, 2017)Background: A monoterpene, perillyl alcohol, has attracted attention in medicinal chemistry since it exhibited chemo-preventive and therapeutic properties against a variety of cancers. Objective: In the present work, it ... -
Design and Characterization of Montelukast Sodium Loaded Kollidon (R) SR Nanoparticles and Evaluation of Release Kinetics and Cytotoxicity Potential
(Colegio Farmaceuticos Provincia De Buenos Aires, 2019)The objective of this research was to design and characterize montelukast sodium (MS) loaded novel nanosized and biocompatible Kollidon (R) SR nanoparticles to provide prolonged release behavior that can improve bioavailability, ... -
Design and characterization of montelukast sodium loaded kollidon® SR nanoparticles and evaluation of release kinetics and cytotoxicity potential
(Colegio de Farmaceuticos de la Provincia de Buenos Aires, 2019)The objective of this research was to design and characterize montelukast sodium (MS) loaded novel nanosized and biocompatible Kollidon® SR nanoparticles to provide prolonged release behavior that can improve bioavailability, ... -
Design and Synthesis of New Benzothiazole Compounds as Selective hMAO-B Inhibitors
(MDPI AG, 2017)In the current work a new class of novel benzothiazole-hydrazone derivatives was designed and synthesized as hMAO-B inhibitors. Structures of the obtained compounds (3a-3j) were characterized by IR, 1H-NMR, 13C-NMR, and ... -
Design, synthesis and in vitro evaluation of new thiosemicarbazone derivatives as potential anticancer agents
(Marmara University, 2019)Thiosemicarbazones play a pivotal role as potential therapeutic agents for the management of lung cancer. 4-(4-Cyanophenyl)-1-[(5-arylfuran-2-yl)methylene]thiosemicarbazides (1-10) were obtained via the reaction of ... -
Determination of antimicrobial and biological activities of salvia sclarea L. (lamiaceae) extracts
(Turkish Chemical Society, 2019)Therapeutic plant species of genus Salvia are important and highly recommended medicinal plant, due to their pharmaceutical properties. In the present study, Salvia sclarea L. was collected during its flowering stage in ... -
Determination of Cytotoxic and Anticandidal Activities of Three Verbascum L. Species from Turkey: V-cheiranthifolium Boiss. var. asperulum (Boiss.) Murb. Monorg., V-pycnostachyum Boiss. & Heldr and V-orgyale Boiss. & Heldr
(Turkish Pharmacists Assoc, 2016)Purpose of this study is to determine of cytotoxic and anticandidal activities of Verbascum cheiranthifolium Boiss. var. asperulum (Boiss.) Murb. Monorg., Verbascum pynostachyum Boiss. & Heldr and Verbascum orgyale Boiss. ... -
Essential Oil Composition of Pimpinella cypria and its Insecticidal, Cytotoxic, and Antimicrobial Activity
(Natural Products Inc, 2016)A water-distilled essential oil (EO) from the aerial parts of Pimpinella cypria Boiss. (Apiaceae), an endemic species in northern Cyprus, was analyzed by GC-FID and GC-MS. Forty-five compounds were identified in the oil, ... -
Essential oil composition of pimpinella cypria and its insecticidal, cytotoxic, and antimicrobial activity
(Natural Product Incorporation, 2016)A water-distilled essential oil (EO) from the aerial parts of Pimpinella cypria Boiss. (Apiaceae), an endemic species in northern Cyprus, was analyzed by GCFID and GC-MS. Forty-five compounds were identified in the oil, ... -
Essential Oil Composition, Antimicrobial and Cytotoxic Activities of Two Endemic Stachys cretica Subspecies (Lamiaceae) from Turkey
(Natural Products Inc, 2010)The chemical compositions of the water-distilled essential oil of Stachys cretica ssp. lesbiaca Rech. fil. and S. cretica ssp. trapezuntica Rech. fil. were determined by GC and GC MS. Altogether 63 compounds were identified. ... -
Evaluation of antimicrobial, Cytotoxic and genotoxic activities of Ganoderma lucidum (Reishi mushroom)
(University Karachi, 2017)Ganoderma lucidum (GL) is a mushroom used as a traditional remedy for the treatment of various infections since ancient times. This study, was aimed to investigate antimicrobial activity potential of GL against Staphylococcus ... -
In vitro preliminary studies of chitooligosaccharide coated nanostructured lipidic nanoparticles for efficient gene delivery
(Marmara University, 2019)Gene therapy is generally defined as the transfer of genetic material to cells to treat a disease or at least improve the clinical condition of a patient. The most commonly used vectors in gene therapy are viral and non-viral ... -
New Benzimidazole-1,2,4-Triazole Hybrid Compounds: Synthesis, Anticandidal Activity and Cytotoxicity Evaluation
(MDPI AG, 2017)Owing to the growing need for antifungal agents, we synthesized a new series 2-((5-(4-(5-substituted-1H-benzimidazol-2-yl)phenyl)-4-substituted-4H-1,2,4-triazol-3-yl)thio)-1-(substituted phenyl)ethan-1-one derivatives, ...