Eczacılık Fakültesi by Institution Author "Atlı Eklioğlu, Özlem"
Now showing items 21-40 of 56
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Evaluation of hepatotoxicity associated with citalopram administration in rats
Baysal, Merve; Atlı Eklioğlu, Özlem; Dagasan, F.; Burukoğlu, D.; Ilgın, Sinem (Elsevier Ireland LTD, 2015)… -
Evaluation of quetiapine-induced hepatotoxicity in rats
Ilgın, Sinem; Atlı Eklioğlu, Özlem; Burukoğlu, Dilek; Baysal, Merve; Hinis, O. (Elsevier Ireland LTD, 2015)… -
Evaluation of the reproductive toxicity of levetiracetam in male rats
Baysal, Merve; Ilgın, Sinem; Kılıç, Volkan; Kılıç, G.; Uçarcan, Şeyda; Atlı Eklioğlu, Özlem (Elsevier Ireland LTD, 2016)… -
Evaluation of the reproductive toxicity of naproxen sodium and meloxicam in male rats
Uzun, B.; Atlı Eklioğlu, Özlem; Perk, B. O.; Burukoğlu, D.; Ilgın, Sinem (SAGE Publications LTD, 2015)Nonsteroidal anti-inflammatory drugs that are cyclooxygenase (COX) enzyme inhibitors have generally been used in short-term pain management and also to treat inflammation chronically. It is known that COX enzyme and ... -
Evidence for cardiotoxicity associated with sertraline in rats
Ilgın, Sinem; Kılıç, Volkan; Baysal, Merve; Aydoğan Kılıç, Gözde; Uçarcan, Şeyda; Dermenci, Begüm; Atlı Eklioğlu, Özlem (Royal Soc Chemistry, 2018)Sertraline is an antidepressant that is frequently prescribed to treat depression, obsessive-compulsive disorder, panic disorder, and anxiety. This drug had a safe cardiotoxicity profile, until the reporting of cases of ... -
Evidence for neurotoxicity associated with amoxicillin in juvenile rats
Atlı Eklioğlu, Özlem; Demir-Özkay, U.; Ilgın, Sinem; Aydın, T. H.; Akbulut, E. N.; Şener, E. (SAGE Publications LTD, 2016)Amoxicillin (AMX) is one of the most commonly prescribed antibiotics for children, and childhood is the period to have the highest risk for toxicity cases including drug-induced adverse reactions. Some neurological adverse ... -
In vitro antitumor activity evaluation of some 1,2,4-triazine derivatives bearing piperazine amide moiety against breast cancer cells
Yurttaş, Leyla; Demirayak, Şeref; Ilgın, Sinem; Atlı Eklioğlu, Özlem (Pergamon-Elsevier Science LTD, 2014)A series of 1,2,4-triazine derivatives bearing piperazine amide moiety has been synthesized and investigated for their potential anticancer activities. 1-[4-(5,6-Bis(4-subtituted phenyl)-1,2,4-triazin-3-yl) piperazin- ... -
Is MCT-induced toxicity limited to the pulmonary vasculature?
Ilgın, Sinem; Atlı Eklioğlu, Özlem; Sırmagül, Başar; Yılmaz, E. Demirel (Elsevier Ireland LTD, 2011)… -
Is N-acetyl cysteine protective against monocrotaline-induced toxicity?
Karagöz, Şerife; Ilgın, Sinem; Atlı Eklioğlu, Özlem; Perk, Başak Özlem; Burukoğlu, Dilek; Ergün, Bülent; Sırmagül, Başar (Taylor & Francis Inc, 2013)Monocrotaline (MCT) is a pyrrolizidine alkaloid which induces cardio-pulmonary toxicity and hepatotoxicity in animals and humans. MCT is frequently ingested because of food grain contamination accidentally or in the form ... -
Matrix metalloproteinases are possible targets in monocrotaline-induced pulmonary hypertension: investigation of anti-remodeling effects of alagebrium and everolimus
Atlı Eklioğlu, Özlem; Ilgın, Sinem; Ergün, Bülent; Burukoğlu, Dilek; Musmul, Ahmet; Sırmagül, Başar (Turkish Soc Cardiology, 2017)Objective: In our study, sildenafil alone and everolimus or alagebrium in combination with sildenafil were investigated in terms of their additional therapeutic and anti-remodeling activity in monocrotaline-induced pulmonary ... -
Neurotoxicity assessment of amoxicillin in juvenile rats
Atlı Eklioğlu, Özlem; Demir-Özkay, U.; Ilgın, Sinem; Aydın, H.; Akbulut, E. N.; Şener, E. (Elsevier Ireland LTD, 2015)… -
A New Series of Pyrrole-Based Chalcones: Synthesis and Evaluation of Antimicrobial Activity, Cytotoxicity, and Genotoxicity
Özdemir, Ahmet; Altıntop, Mehlika Dilek; Sever, Belgin; Karaca Gencer, Hülya; Kapkac, Handan Acelya; Atlı Eklioğlu, Özlem; Baysal, Merve (MDPI AG, 2017)In an effort to develop new potent antimicrobial and anticancer agents, new pyrrole-based chalcones were designed and synthesized via the base-catalyzed Claisen-Schmidt condensation of 2-acetyl-1-methylpyrrole with ... -
A novel series of thiazolyl-pyrazoline derivatives: Synthesis and evaluation of antifungal activity, cytotoxicity and genotoxicity
Altıntop, Mehlika Dilek; Özdemir, Ahmet; Turan, Gülhan; Ilgın, Sinem; Atlı Eklioğlu, Özlem; Demirel, Rasime; Kaplancıklı, Zafer Asım (Elsevier France-Editions Scientifiques Medicales Elsevier, 2015)In the current work, new thiazolyl pyrazoline derivatives (1-22) were synthesized and evaluated for their antifungal effects against pathogenic yeasts and molds using a broth microdilution assay. Ames assay was carried out ... -
Pharmacological and Toxicological Screening of Novel Benzimidazole-Morpholine Derivatives as Dual-Acting Inhibitors
Can, Nafiz Öncü; Çevik, Ulviye Acar; Sağlık, Begüm Nurpelin; Özkay, Yusuf; Atlı Eklioğlu, Özlem; Baysal, Merve; Can, Özgür Devrim (MDPI, 2017)The aim of this study was to investigate acetylcholinesterase (AChE), monoamine oxidase A (MAO-A), monoamine oxidase B (MAO-B), cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2) enzyme inhibitory, and antimicrobial ... -
Reproductive toxicity after levetiracetam administration in male rats: Evidence for role of hormonal status and oxidative stress
Baysal, Merve; Ilgın, Sinem; Aydoğan Kılıç, Gözde; Kılıç, Volkan; Uçarcan, Şeyda; Atlı Eklioğlu, Özlem (Public Library Science, 2017)Levetiracetam (LEV) is an antiepileptic drug commonly used in the treatment of epilepsy because of its excellent safety profile in all age groups. It is remarkable that there are no studies evaluating the toxic effects of ... -
Sertraline-induced reproductive toxicity in male rats: evaluation of possible underlying mechanisms
Atlı Eklioğlu, Özlem; Baysal, Merve; Aydoğan Kılıç, Gözde; Kılıç, Volkan; Uçarcan, Şeyda; Karaduman, Abdullah Burak; Ilgın, Sinem (Wolters Kluwer Medknow Publications, 2017)This study was conducted to clarify the toxic effects of sertraline (SRT) on the reproductive system of male rats and to elucidate the underlying mechanisms. Rats were treated orally with SRT at doses of 5, 10, and 20 mg ... -
Synthesis and anticancer activity of some novel benzothiazole-thiazolidine derivatives
Osmaniye, Derya; Levent, Serkan; Ardıç, Cankiz Mina; Atlı Eklioğlu, Özlem; Özkay, Yusuf; Kaplancıklı, Zafer Asım (Taylor & Francis LTD, 2018)Sixteen new 2-(benzothiazol-2-ylthio)-N-(3-substituted-4-(3,4-substitutedphenyl)thiazol-2(3H)-ylidene)acetohydrazide derivatives (4a-4p) were synthesized. The structures of the synthesized compounds were elucidated using ... -
Synthesis and Anticandidal Activity of New Imidazole-Chalcones
Osmaniye, Derya; Kaya Çavuşoğlu, Betül; Sağlık, Begüm Nurpelin; Levent, Serkan; Çevik, Ulviye Acar; Atlı Eklioğlu, Özlem; Kaplancıklı, Zafer Asım (MDPI, 2018)In the present work, 15 new 1-(4-(1H-imidazol-1-yl)phenyl)-3-(4-substituedphenyl) prop-2-en-1-one derivatives (3a-3o) were synthesized to evaluate their antifungal activity. Structures of newly synthesized imidazole ... -
Synthesis and biological evaluation of new naphthalene substituted thiosemicarbazone derivatives as potent antifungal and anticancer agents
Altıntop, Mehlika Dilek; Atlı Eklioğlu, Özlem; Ilgın, Sinem; Demirel, Rasime; Özdemir, Ahmet; Kaplancıklı, Zafer Asım (Elsevier France-Editions Scientifiques Medicales Elsevier, 2016)New thiosemicarbazone derivatives (1-10) were obtained via the reaction of 4-(naphthalen-1-yl)thiosemicarbazide with fluoro-substituted aromatic aldehydes. The synthesized compounds were evaluated for their in vitro ... -
Synthesis and Biological Evaluation of New Pyrazole-based Thiazolyl Hydrazone Derivatives as Potential Anticancer Agents
Altıntop, Mehlika Dilek; Özdemir, Ahmet; Ilgın, Sinem; Atlı Eklioğlu, Özlem (Bentham Science Publ LTD, 2014)New pyrazole-based thiazolyl hydrazone derivatives were obtained via the ring closure reaction of 3,5-dimethyl-1H-1-phenylpyrazole-4-carboxaldehyde thiosemicarbazone with 2-bromoacetophenone derivatives. The compounds were ...