Kurum Yazarı "Dikmen, Miriş" Eczacılık Fakültesi İçin Listeleme
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Escitalopram oxalate, a selective serotonin reuptake inhibitor, exhibits cytotoxic and apoptotic effects in glioma C6 cells
Dikmen, Miriş; Cantürk, Zerrin; Öztürk, Yusuf (Cambridge University Press, 2011)Objective: Various antidepressants, mainly tricyclic antidepressants (TCAs) and selective serotonin reuptake inhibitors (SSRIs), have been reported to exhibit potent anticancer properties in different cancer cells. In this ... -
Evaluation of Antiangiogenic and Antimetastatic Effects of Penicillium chrysogenum Secondary Metabolites
Dikmen, Miriş; Cantürk, Zerrin; Tilki, E. Kaya; EnGür, Selin (Medknow Publications & Media Pvt LTD, 2017)Development of resistance to standard therapy and toxic side effects are the major challenges encountered in chemotherapy of colorectal cancer. Increasing evidence has shown the ability of natural products to overcome ... -
Evaluation of neuritogenic activity of cultivated, wild and commercial roots of Gentiana lutea L.
Mustafa, Ahmed M.; Caprioli, Giovanni; Dikmen, Miriş; Kaya, Elif; Maggi, Filippo; Sagratini, Gianni; Öztürk, Yusuf (Elsevier Science BV, 2015)Several natural products have been proven to prevent neurodegenerative disorders by potentiating the action of nerve growth factor (NGF). Among them, secoiridoids have recently attracted interest for their potential use ... -
Evaluation of the antileukemic effects of neurokinin-1 receptor antagonists, aprepitant, and L-733,060, in chronic and acute myeloid leukemic cells
Dikmen, Miriş; Gökhaner, Gökhan; Cantürk, Zerrin (Lippincott Williams & Wilkins, 2019)Neurokinin-1 receptor (NK1R) antagonists are known for their anxiolytic, antiemetic, anticancer, and antiinflammatory effects. Aprepitant is used in vomiting and nausea, which are the most common side-effects of patients ... -
Evaluation of the Wound Healing Potentials of Two Subspecies of Hypericum perforatum on Cultured NIH3T3 Fibroblasts
Dikmen, Miriş; Öztürk, Yusuf; Sagratini, Gianni; Ricciutelli, Massimo; Vittori, Sauro; Maggi, Filippo (Wiley-Blackwell, 2011)For centuries, Hypericum perforatum has been used in folk medicine to treat wounds. In the present study, the wound healing activities of extracts of H. perforatum ssp. perforatum (HPP) and H. perforatum ssp. veronense ... -
Inflammatory aspects of epileptogenesis: contribution of molecular inflammatory mechanisms
Alyu, Feyza; Dikmen, Miriş (Cambridge University Press, 2017)Objective Epilepsy is a chronic neurological disease characterised with seizures. The aetiology of the most generalised epilepsies cannot be explicitly determined and the seizures are pronounced to be genetically determined ... -
Inhibition of C6 Glioma Cell Proliferation by Au(III) and Pt(II) Complexes of 1,10-Phenanthroline-5,6-dione
Dikmen, Miriş; Benkli, Kadriye; Öztürk, Yusuf (Asian Journal Of Chemistry, 2011)In this study, we studied the antiproliferative effecs of Au(III) and Pt(II) metal complexes of 1,10-phenanthroline-5,6-dione and cisplatin on rat glioma C6 cells. The antiproliferative effects were evaluated by MTT ... -
Inhibitory effects of secondary metabolites of halotolerant aspergillus terreus on angiogenesis
Dikmen, Miriş; Cantürk, Zerrin; Engür, Selin; Kaya, Tilki, E. (Scientific Publishers of India, 2017)Angiogenesis inhibitors have been currently developed which offer the hope of new treatment options such as diabetic retinopathy, psoriasis, rheumatoid arthritis and cancer. Fungi have been known (as) a wide useful source ... -
Inhibitory effects of secondary metabolites of halotolerant Aspergillus terreus on angiogenesis.
Dikmen, Miriş; Cantürk, Zerrin; Engür, Selin; Tilki, Kaya E. (Allied Acad, 2017)Angiogenesis inhibitors have been currently developed which offer the hope of new treatment options such as diabetic retinopathy, psoriasis, rheumatoid arthritis and cancer. Fungi have been known (as) a wide useful source ... -
Investigation of association between plasminogen activator inhibitor type-1 (PAI-1) gene 4G/5G polymorphism frequency and plasma PAI-1 enzyme activity in patients with acute stroke
Küçükarabacı, Banu; Güneş, Hasan Veysi; Özdemir, Gazi; Coşan, Didem; Ozbabalik, Demet; Dikmen, Miriş; Değirmenci, İrfan (Mary Ann Liebert, Inc, 2008)Aim: This study was carried out to determine if there is any association between plasminogen activator inhibitor type-1 (PAI-1) gene 4G/5G polymorphism and plasma PAI-1 enzyme activity in acute stroke patients. Methods: ... -
Investigation of the Apoptotic Effect of Curcumin in Human Leukemia HL-60 Cells by Using Flow Cytometry
Dikmen, Miriş; Cantürk, Zerrin; Öztürk, Yusuf; Tunalı, Yağmur (Mary Ann Liebert, Inc, 2010)Curcumin (diferuloylmethane), the major yellow pigment isolated from the turmeric (Curcuma longa), has received much attention due to several biological properties. Curcumin exhibits a variety of pharmacological effects ... -
Is there any role of G-protein estrogen receptor gene (GPR30) polymorphism in development of schizophrenia?
Özen, Murat Eren; Dikmen, Miriş; Tap, Duygu; Özler, Sinan; Yılmaz, Mehmet Bertan; Urhan Küçük, Meral (Cumhuriyet University Tip Fak Psikiyatri Anabilim Dali, 2019)Objectives: Schizophrenia is a complex neuropsychiatric disorder that affects approximately 1% of the population. Estrogens may play an important role in the etiology and treatment of this disorder. They mediate effect by ... -
Isofuranodiene: A neuritogenic compound isolated from wild celery (Smyrnium olusatrum L., Apiaceae)
Mustafa, Ahmed M.; Maggi, Filippo; Papa, Fabrizio; Kaya, Elif; Dikmen, Miriş; Öztürk, Yusuf (Elsevier Sci LTD, 2016)In the search for neuroactive compounds that mimic the nerve growth factor (NGF) activity for the protection against neurodegenerative diseases, the potential medicinal values of foods and plants attracts intense interest. ... -
Mianserin'in sıçanlarda streptozotosin ile indüklenen hiperglisemi ve metabolik değişiklikler üzerine etkisi
Amaç: Bu çalışmada, atipik bir antidepresan olan mianserin'in normoglisemik ve diyabetik sıçanlarda glisemi düzeyi ve metabolik parametreler üzerine olası etkilerinin araştırılması amaçlanmıştır. Gereç ve Yöntem: Mianserin'in ... -
Mianserin’in sıçanlarda streptozotosin ile indüklenen hiperglisemi ve metabolik değişiklikler üzerine etkisi
Amaç: Bu çalışmada, atipik bir antidepresan olan mianserin’in normoglisemik ve diyabetik sıçanlarda glisemi düzeyi ve metabolik parametreler üzerine olası etkilerinin araştırılması amaçlanmıştır. Gereç ve Yöntem: Mianserin’in ... -
mTOR Inhibitors in the Treatment of Cancer
Özcan, Özge; Dikmen, Miriş (Marmara University, Fac Pharmacy, 2015)The mammalian target of rapamycin (mTOR) is a highly conserved in evolution serine/threonine kinase belonging to the phosphatidylinositol kinase related protein kinases family. mTOR plays a central role in regulation of a ... -
Neuritogenic Activity of Epigallocatechin Gallate and Curcumin Combination on Rat Adrenal Pheochromocytoma Cells
Dikmen, Miriş; Kaya-Tilki, Elif; Engür, Selin; Öztürk, Yusuf (Parlar Scientific Publications (PSP), 2017)Plant phytochemicals are important neuroprotective agents which mainly act as antioxidants by scavenging stress -induced free radicals in the brain. Phytochemicals from medicinal plants including epigallocatechin gallate ... -
New piperidine-hydrazone derivatives: Synthesis, biological evaluations and molecular docking studies as AChE and BChE inhibitors
Karaman, Nurcan; Sıcak, Yusuf; Taşkın-Tok, Tuğba; Öztürk, Mehmet; Karakuçuk-İyidoğan, Ayşegül; Dikmen, Miriş; Oruç-Emre, Emine Elçin (Elsevier France-Editions Scientifiques Medicales Elsevier, 2016)Hydrazones and the piperidine ring containing compounds were considered as beneficial substrates in drug design. Therefore, this study was aimed at the synthesis of new benzoyl hydrazones derived from ethyl 4-oxopiperidi ... -
Plasminogen Activator Inhibitor Type-1 Gene 4G/5G Polymorphism Is Associated with Hypertensive Patients in the Turkish Population
Güneş, Hasan Veysi; Coşan, Didem Turgut; Ata, Necmi; Birdane, Alparslan; Üstüner, Mehmet Cengiz; Dikmen, Miriş; Değirmenci, İrfan (Mary Ann Liebert Inc, 2010)This study has been performed on hypertensive patients in the Turkish population to determine the frequency of 4G/5G polymorphism genotypes of plasminogen activator inhibitor type-1 gene and with the aim of examining the ... -
Synthesis and Anticancer Activity of New Hydrazide-hydrazoncs and Their Pd(II) Complexes
Koçyiğit-Kaymakçıoğlu, Bedia; Yazıcı, Senem Sinem; Tok, Fatih; Dikmen, Miriş; EnGür, Selin; Oruç-Emre, Emine Elçin; Iyidoğan, Ayşegül (Bentham Science Publ LTD, 2019)Background: Hydrazones, one of the important classes of organic molecules, are pharmaceutical agents comprising -CO-NH-N=CH- group in the structure therefore and exhibiting significant biological activity. Methods: ...