Yazar "Turan, Gülhan" için Eczacılık Fakültesi listeleme
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Synthesis and Biological Evaluation of some Amide Derivatives Bearing Benzothiazole and Piperidine Moieties as Antimicrobial Agents
Altıntop, Mehlika Dilek; Özdemir, Ahmet; Kaplancıklı, Zafer Asım; Turan, Gülhan; İşcan, Gökalp; Çiftçi, Gülsen Akalın (Bentham Science Publ LTD, 2013)In this study, N-(benzothiazol-2-yl)-2-(piperidin-1-yl)acetamide derivatives (1-24) were obtained by the reaction of 2-chloro-N-(benzothiazole-2-yl)acetamides with piperidine derivatives. The structures of the compounds ... -
Synthesis and Biological Evaluation of Some Hydrazone Derivatives as Anti-inflammatory Agents
Kaplancıklı, Zafer Asım; Altıntop, Mehlika Dilek; Özdemir, Ahmet; Turan, Gülhan; Khan, Shabana I.; Tabanca, Nurhayat (Bentham Science Publ LTD, 2012)In the present study, some hydrazone derivatives were synthesized via the reaction of 3-cyclohexylpropionic acid hydrazide with various benzaldehydes. The chemical structures of the compounds were elucidated by spectroscopic ... -
Synthesis and biological evaluation of some hydrazone derivatives as new anticandidal and anticancer agents
Altıntop, Mehlika Dilek; Özdemir, Ahmet; Turan, Gülhan; Ilgın, Sinem; Atlı Eklioğlu, Özlem; İşcan, Gökalp; Kaplancıklı, Zafer Asım (Elsevier France-Editions Scientifiques Medicales Elsevier, 2012)New hydrazone derivatives were synthesized via the nucleophilic addition-elimination reaction of 2-[(1-methyl-1H-tetrazol-5-yl]thio)]acetohydrazide with aromatic aldehydes/ketones. The compounds were tested in vitro against ... -
Synthesis and Biological Evaluation of Some Pyrazoline Derivatives Bearing a Dithiocarbamate Moiety as New Cholinesterase Inhibitors
Altıntop, Mehlika Dilek; Özdemir, Ahmet; Kaplancıklı, Zafer Asım; Turan, Gülhan; Temel, Halide Edip; Çiftçi, Gülsen Akalın (Wiley-V C H Verlag GMBH, 2013)In the present study, new pyrazoline derivatives were synthesized via the reaction of 1-(chloroacetyl)-3-(2-furyl)-5-aryl-2-pyrazolines with sodium salts of N,N-disubstituted dithiocarbamic acids. Each derivative was ... -
Synthesis and biological evaluation of some thiazole derivatives as new cholinesterase inhibitors
Turan, Gülhan; Özdemir, Ahmet; Kaplancıklı, Zafer Asım; Altıntop, Mehlika Dilek; Temel, Halide Edip; Çiftçi, Gülsen Akalın (Informa Healthcare, 2013)In the present study, some thiazole derivatives were synthesized via the ring closure reaction of 1-[2-(2-oxobenzo[d] thiazol-3(2H)-yl)acetyl]thiosemicarbazide with various phenacyl bromides. The chemical structures of the ... -
Synthesis and characterization of some 2-(substituted arylacylthio)thiazolene derivatives
Turan, Gülhan; Sezgin, S. (1998)In this study, five new 2-(substituted arylacyl-thio) thiazoline derivatives were synthesized by reacting 2-thiazoline-2-thiol with arlacylhalides. The structures of the compounds obtained were elucidated by IR, 1H-NMR, ... -
Synthesis and Evaluation of a Series of 1,3,4-Thiadiazole Derivatives as Potential Anticancer Agents
Altıntop, Mehlika Dilek; Sever, Belgin; Özdemir, Ahmet; Ilgın, Sinem; Atlı Eklioğlu, Özlem; Turan, Gülhan; Kaplancıklı, Zafer Asım (Bentham Science Publ LTD, 2018)Background and Methods: In an attempt to develop potent antitumor agents, the synthesis of a series of N-(6-substituted benzothiazol-2-yl)-2-1(5-(arylamino)-1,3,4-thiadiazol-2-yl)thiolacetamides (1-14) was described and ... -
Synthesis and evaluation of bis-thiazole derivatives as new anticancer agents
Turan, Gülhan; Altıntop, Mehlika Dilek; Özdemir, Ahmet; Kaplancıklı, Zafer Asım; Çiftçi, Gülsen Akalın; Temel, Halide Edip (Elsevier France-Editions Scientifiques Medicales Elsevier, 2016)New bis-thiazole derivatives (1-10) were synthesized via the ring closure of 1,1'-(3,3'-dimethoxybipheny1-4,4'-diyl)bis(thiourea) with phenacyl bromides and evaluated for their cytotoxic effects on A549 human lung ... -
Synthesis and Evaluation of N-[1-(((3,4-Diphenylthiazol-2(3H)-ylidene)amino)methyl)cyclopentyl]acetamide Derivatives for the Treatment of Diseases Belonging to MAOs
Turan, Gülhan; Tabbi, Aouatef; Hussein, Weiam; Karaduman, Abdullah Burak; Sağlık, Begüm Nurpelin; Özkay, Yusuf (Hindawi LTD, 2018)A series of N-[1-(((3,4-diphenylthiazol-2(3H)-ylidene)amino)methyl)cyclopentyl]acetamide derivatives (4a-4i) were synthesized in good yield and assayed for their inhibitory potency against monoamine oxidase (MAO) isoforms. ... -
Synthesis and Evaluation of New 1,5-Diaryl-3-[4-(methyl-sulfonyl)phenyl]-4,5-dihydro-1H-pyrazole Derivatives as Potential Antidepressant Agents
Özdemir, Ahmet; Altıntop, Mehlika Dilek; Kaplancıklı, Zafer Asım; Can, Özgür Devrim; Özkay, Ümide Demir; Turan, Gülhan (MDPI, 2015)In an effort to develop potent antidepressant agents, new pyrazoline derivatives 2a-s were synthesized and evaluated for their antidepressant-like activity by tail suspension test (TST) and modified forced swimming test ... -
Synthesis and evaluation of new indole-based chalcones as potential antiinflammatory agents
Özdemir, Ahmet; Altıntop, Mehlika Dilek; Turan, Gülhan; Çiftçi, Gülsen Akalın; Ertorun, İpek; Alataş, Özkan; Kaplancıklı, Zafer Asım (Elsevier France-Editions Scientifiques Medicales Elsevier, 2015)In the present work, new indole-based chalcone derivatives were obtained via the reaction of 5-substituted-1H-indole-3-carboxaldehydes/1-methylindole-3-carboxaldehyde with appropriate acetophenones. The synthesized compounds ... -
Synthesis and evaluation of new thiadiazole derivatives as potential inhibitors of human carbonic anhydrase isozymes (hCA-I and hCA-II)
Altıntop, Mehlika Dilek; Özdemir, Ahmet; Küçükoğlu, Kaan; Turan, Gülhan; Nadaroğlu, Hayrunnisa; Kaplancıklı, Zafer Asım (Informa Healthcare, 2015)2-[[5-(2,4-Difluoro/dichlorophenylamino)-1,3,4-thiadiazol-2-yl]thio] acetophenone derivatives (3a-s) were designed as human carbonic anhydrase isozymes (hCA-I and hCA-II) inhibitors and synthesized. hCA-I and hCA-II were ... -
Synthesis and Evaluation of Thiazole - Pyrimidine Derivatives as New Anticandidal and Cytotoxic Agents
Turan, Gülhan; Altıntop, Mehlika Dilek; Kaplancıklı, Zafer Asım; Özdemir, Ahmet; Demirci, Fatih; Ilgın, Sinem; Göğer, Gamze (Springer, 2014)The aim of this study was to describe the synthesis of four new 2-(3,4-diphenyl-3H-thiazol-2-ylidene)amino-4,6-dimethylpyrimidine derivatives, which were screened for their anticandidal activity and cytotoxicity. The title ... -
Synthesis and in Vitro Evaluation of New Nitro-Substituted Thiazolyl Hydrazone Derivatives as Anticandidal and Anticancer Agents
Altıntop, Mehlika Dilek; Özdemir, Ahmet; Turan, Gülhan; Ilgın, Sinem; Atlı Eklioğlu, Özlem; Demirci, Fatih; Kaplancıklı, Zafer Asım (MDPI AG, 2014)Fourteen new thiazolyl hydrazone derivatives were synthesized and evaluated for their anticandidal activity using a broth microdilution assay. Among the synthesized compounds, 2-[2-((5-(4-chloro-2-nitrophenyl) furan-2-yl) ... -
Synthesis and In Vitro Evaluation of Some Hydrazone Derivatives as Potential Antibacterial Agents
Kaplancıklı, Zafer Asım; Altıntop, Mehlika Dilek; Özdemir, Ahmet; Turan, Gülhan; Göğer, Gamze; Demirci, Fatih (Bentham Science Publ LTD, 2014)Nineteen N'-(benzylidene)-2-[(pyrimidin-2-yl)thio]acetohydrazides were obtained via the nucleophilic addition-elimination reaction of 2-[(pyrimidin-2-yl)thio)]acetohydrazide with aromatic aldehydes. The synthesized compounds ... -
Synthesis and structure of derivatives of [?-(N-substituted aminothiocarbonylthio)acetyl] substituted phenols [SYNTHESE ET STRUCTURE DES DERIVES DE [?-(N-SUBSTITUES AMINOTHIOCARBONYLTHIO)ACETYL]-2 PHENOLS SUBSTITUES]
Turan, Gülhan; Öncel, A. (1994)In this study, 2-[?-(N-substituted aminothiocarbonylthio)acetyl] substituted phenols were synthesized and their structures were elucidated by IR, NMR and elemental analyses. -
Synthesis and study of antibacterial and antifungal activities of novel 2-[[(benzoxazole/benzimidazole-2-yl)sulfanyl] acetylamino]thiazoles
Kaplancıklı, Zafer Asım; Turan, Gülhan; Revial, G; Güven, Kıymet (Pharmaceutical Soc Korea, 2004)Several 2-[[(benzoxazole/benzimidazole-2-yl)sulfanyl]acetylamino]thiazoles derivatives were synthesized by reacting 4-substituted-2-(chloroacetylamino)thiazoles with benzoxazole/benzimidazole-2-thioles in acetone and in ... -
Synthesis and the selective antifungal activity of 5,6,7,8-tetrahydroimidazo[1,2-a]pyridine derivatives
Özdemir, Ahmet; Turan, Gülhan; Kaplancıklı, Zafer Asım; İşcan, Gökalp; Khan, Shabana I.; Demirci, Fatih (Elsevier France-Editions Scientifiques Medicales Elsevier, 2010)Even though there are new classes of compounds now frequently used in treatment of fungal infections, the density of deeply invasive candidiasis has increased at least 10-fold during the past decade. Furthermore, many ... -
Synthesis of 1-acetyl-3-(2-thienyl)-5-aryl-2-pyrazoline derivatives and evaluation of their anticancer activity
Özdemir, Ahmet; Altıntop, Mehlika Dilek; Kaplancıklı, Zafer Asım; Turan, Gülhan; Çiftçi, Gülsen Akalın; Yıldırım, Şafak Ulusoylar (Informa Healthcare, 2013)In the present study, 1-acetyl-3-(2-thienyl)-5-aryl-2-pyrazoline derivatives (1-6) were synthesized via the ring closure reaction of 1-(2-thienyl)-3-aryl-2-propen-1-ones with hydrazine hydrate in acetic acid. The chemical ...