Yazar "Şener, Erol" için Eczacılık Fakültesi listeleme
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Ciprofloxacin-induced neurotoxicity: evaluation of possible underlying mechanisms
Ilgın, Sinem; Can, Özgür Devrim; Atlı Eklioğlu, Özlem; Ucel, Umut İrfan; Şener, Erol; Güven, İlkay (Taylor & Francis LTD, 2015)Ciprofloxacin (CPX) is a fluoroquinolone antibiotic used for treating respiratory, urinary tract, gastrointestinal and abdominal infections. There are only a limited number of studies related to neurological adverse effects ... -
Determination of Ochratoxin-A in the brain microdialysates and plasma of awake, freely moving rats using ultra high performance liquid chromatography fluorescence detection method
Kaya, Erbil Melek Özlem; Korkmaz, Orhan Tansel; Uğur, Duygu Yeniceli; Şener, Erol; Tuncel, A. Neşe; Tunçel, Muzaffer (Elsevier, 2019)In this study, a simple, efficient and rapid Ultra High Performance Liquid Chromatography method with fluorescence detection (UHPLC-FLD) has been developed and validated for the determination of Ochratoxin-A (OTA) in rat ... -
The determination of prazosin hydrochloride in pharmaceutical preparations by flow injection analysis using UV-detection
Atkoşar, Zeki; Altıokka, Göksel; Kırcalı, K.; Şener, Erol (2001)A flow Injection Analysis(FIA) of prazosin hydrochloride (PRZ) using UV detection is described. Methanolic HCl(0.2 mol.l-1) was used as the solvent. A flow rate of 1 ml.min-1 was pumped and the active material was detected ... -
Development and Validation of a New HPLC Method for the Determination of Quetiapine and Its Metabolites 7- Hydroxy Quetiapine and Quetiapine Sulfoxide in Rat Plasma
Sıçan plazmasında ketiapin ve metabolitleri 7-hidroksi ketiapin ve ketiapin sülfoksit'in tayini için yeni bir yüksek performanslı sıvı kromatografisi yöntemi geliştirilmiş ve valide edilmiştir. Ayrım, C18 kolon (Zorbax ... -
Development of a Simple and Specific Uhplc Assay for the Determination of Aripiprazole and Dehydroaripiprazole in Rat Plasma
Uğur, Duygu Yeniceli; Yılmaz, Işıl T.; Şener, Erol (Soc Chilena Quimica, 2015)A new, simple, specific, and rapid ultra high performance liquid chromatography method was developed and validated for the determination of aripiprazole and its active metabolite dehydroaripiprazole in rat plasma. The ... -
The effect of pea (Pisum sativum L.)-originated asparaginase on acrylamide formation in certain bread types
Tuncel, Necati B.; Yılmaz, Neşe; Şener, Erol (Wiley-Blackwell Publishing, Inc, 2010)P>The aim of this study was to investigate the effect of pea (Pisum sativum L.)-originated asparaginase on acrylamide formation in white wheat, wheat bran and whole-grain wheat breads. Two-day germinated pea flour was used ... -
Evaluation of the antithrombotic effects of Crataegus monogyna and Crataegus davisii in the carrageenan-induced tail thrombosis model
Arslan, Rana; Bektaş, Nurcan; Bor, Zeynep; Şener, Erol (Informa Healthcare, 2015)Context: Crataegus species are widely used as herbal medicines for preventing cardiovascular diseases (CVDs). However, there are no studies on the effects of Crataegus monogyna Jacq. (Rosaceae) and C. davisii Browicz on ... -
Modulation of Corpus Striatal Neurochemistry by Astrocytes and Vasoactive Intestinal Peptide (VIP) in Parkinsonian Rats
Yelkenli, İbrahim Halil; Ulupınar, Emel; Korkmaz, Orhan Tansel; Şener, Erol; Kuş, Gökhan; Filiz, Zeynep; Tuncel, Neşe (Humana Press Inc, 2016)The neurotoxin 6-hydroxydopamine (6-OHDA) is widely used in animal models of Parkinson's disease. In various neurodegenerative diseases, astrocytes play direct, active, and critical roles inmediating neuronal survival and ... -
Preparation and Characterization of Rivaroxaban Nanocrystals Prepared by Combination of Wet Ball Milling and High Pressure Homogenization Methods
Demir, Huriye; Gülsün, Tuğba; Şener, Erol; Şahin, Selma; Öner, Levent (Colegio Farmaceuticos Provincia De Buenos Aires, 2018)The objectives of this study were to develop rivaroxaban (RXB) nanocrystals by combination of wet ball milling and high-pressure homogenization, and to increase the solubility and dissolution rate of RXB. A new nanocrystal ... -
A sensitive capillary LC-UV method for the simultaneous analysis of olanzapine, chlorpromazine and their FMO-mediated N-oxidation products in brain microdialysates
Hendrickx, Stijn; Uğur, Duygu Yeniceli; Yılmaz, Işıl Tan; Şener, Erol; Van Schepdael, Ann; Adams, Erwin; Cabooter, Deirdre (Elsevier Science BV, 2017)A specific and sensitive capillary liquid chromatography-ultraviolet detection (cap-LC-UV) method in combination with a micro-extraction by packed sorbent (MEPS) sample clean-up procedure has been developed and validated ... -
A simple and sensitive LC-ESI-MS (ion trap) method for the determination of bupropion and its major metabolite, hydroxybupropion in rat plasma and brain microdialysates
Yeniceli, Duygu; Şener, Erol; Korkmaz, Orhan Tansel; Ak, Dilek; Tuncel, Neşe (Elsevier Science BV, 2011)A specific and highly sensitive liquid chromatography-electrospray mass spectrometry (LC-ESI-MS) method for the direct determination of bupropion (BUP) and its main metabolite hydroxybupropion (HBUP) in rat plasma and brain ... -
Simultaneous Determination of Substance P and CGRP in Rat Brainstem Tissue Using LC-ESI-MS/MS Method
Alasag, Neva; Şener, Erol; Ak, Dilek (Bentham Science Publ LTD, 2018)Background: Substance P and CGRP are neuropeptides that belong to the thachykinin and calcitonin family, respectively. They play an important role in neuropathic pain development and regulation. Methods: In this study, ...