Eczacılık Fakültesi by Institution Author "Seller, Zerrin"
Now showing items 1-20 of 42
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Anticancer Activity of Some Bisbenzimidazoles
Işıkdağ, İlhan; Özkay, Yusuf; İncesu, Zerrin; Akalın Çiftçi, Gülsen (Verlag Z Naturforsch, 2011)The discovery of DNA topoisomerases has added a new dimension to the study of anticancer drugs. Bishenzimidazole derivatives are important compounds known as DNA topoisomerase 1 inhibitors. In the present study, some ... -
Antimicrobial and anticancer effects of some 2-(substitutedsulfanyl)-N-(5-methyl-isoxazol-3-yl)acetamide derivatives
Özkay, Yusuf; Seller, Zerrin; Önder, Nur İpek; Tunalı, Yağmur; Karaca Gencer, Hülya; Işıkdağ, İlhan; Uçucu, Ümit (Springer Birkhauser, 2013)In the present study, some isoxazole-(benz)azole derivatives (3a-3j) were synthesized by considering antimicrobial and anticancer potencies of azole compounds. Chemical structures of obtained compounds (3a-3j) were confirmed ... -
The antimutagenic and antimitotic properties of the extract of the lichen Cetraria aculeata
Sivas, Hülya; Seller, Zerrin; Tüylü, Berrin; Türk, A; Barutca, B (Academic Press Inc Elsevier Science, 2004)… -
Antiproliferative effects of some N-benzylideneanilines
Özkay, Yusuf; Seller, Zerrin; Işıkdağ, İlhan; Yesilkaya, Mehmet (John Wiley & Sons LTD, 2008)A series of Schiff bases including N-benzylideneaniline (NBA) nuclei were prepared. The chemical products obtained were characterized by mass spectometry (APCI), H-1 NMR, and IR spectroscopy in order to seek their cytotoxic ... -
Apoptotic effects of epsilon-viniferin in combination with cis-platin in C6 cells
Özdemir, Filiz; Apaydın, Elif; Önder, Nur İpek; Şen, Mesut; Ayrim, Aysun; Öğünç Keçeci, Yüksel; Seller, Zerrin (Springer, 2018)Glioblastoma (GBM) is one of the most common and lethal forms of primary brain tumors in human adults. Treatment options are limited, and in most cases ineffective. Natural products are sources of novel compounds endowed ... -
Apoptotic Effects of Some Thiohydantoin Derivatives
Seller, Zerrin; Akalın Çiftçi, Gülsen (Turkish Biochem Soc, 2010)Objectives: The aim of this study is to investigate the effects of newly synthesized 3-phenly-and 3-(4-methoxyphenyl)-2-thiohydantoin derivatives on 5RP7 ve CO25 cell apoptosis. Methods and Materials: Thiohydantoin derivatives ... -
Apoptotic effects of some thiohydantoin derivatives [Bazi{dotless} Tiyohidantoin Türevlerinin Apoptotik Etkileri]
Seller, Zerrin; Akalın Çiftçi, Gülsen (2010)Objectives: The aim of this study is to investigate the effects of newly synthesized 3-phenly-and 3-(4-methoxyphenyl)-2-thiohydantoin derivatives on 5RP7 ve CO25 cell apoptosis. Methods and Materials: Thiohydantoin derivatives ... -
Cytotoxic effects of some perimidine derivatives on F2408 and 5Rp7 cell lines
Işıkdağ, İlhan; Seller, Zerrin; Gülnaz, D.; Özkay, Yusuf (2008)In this study twenty perimidine derivatives were prepared in order to seek their cytotoxic and antiproliferative effects on normal rat embryo fibroblast (F2408) and carcinogenic rat embryo fibroblast (5RP7) cell lines. ... -
Cytotoxicity Screening, Antioxidant Activity and Phenolic Profile of Two Species of Thymus on Human Cervical and Ovarian Cancer Cells Lines in Vitro
Özdemir, Filiz; Küçük, Sevim; Göğer, Fatih; Seller, Zerrin (Parlar Scientific Publications (PSP), 2017)The aim of this study was to determine of cytotoxic, antioxidant activity and phenolic profile of the two species of Thymus which are Thymus sipyleus Boiss. and Thymus leucostomus Hausskn. et Velen. (endemic). For this ... -
Determination of apoptosis on fibronectin and collagen iv adhered 5RP7 cells [Fi·bronekti·n ve kolajen iv'e bagli 5RP7 hücreleri·nde apoptozun beli·rlenmesi·]
Seller, Zerrin; Fırat, Ç.; Aydoğdu, Ş. (2009)Extracellular proteins such as fibronectin and collagen IV have a function in many cellular events such as cell growth, cell differentiation, tissue formation, cell adhesion, wound healing as well as have an important ... -
Determination of Cytotoxic and Anticandidal Activities of Three Verbascum L. Species from Turkey: V-cheiranthifolium Boiss. var. asperulum (Boiss.) Murb. Monorg., V-pycnostachyum Boiss. & Heldr and V-orgyale Boiss. & Heldr
Küçük, Sevim; Özdemir, Filiz; İşcan, Gökalp; Seller, Zerrin (Turkish Pharmacists Assoc, 2016)Purpose of this study is to determine of cytotoxic and anticandidal activities of Verbascum cheiranthifolium Boiss. var. asperulum (Boiss.) Murb. Monorg., Verbascum pynostachyum Boiss. & Heldr and Verbascum orgyale Boiss. ... -
Determination of Phenolic Compounds, Cytotoxic, Antioxidant and Anticandidal Effects of Tribulus Terrestris L. (Zygophyllaceae)
Küçük, Sevim; Göğer, Fatih; İşcan, Gökalp; Özdemir, Filiz; Kırımer, Neşe; Seller, Zerrin (Parlar Scientific Publications (PSP), 2017)This study was investigated the potential cytotoxic, antioxidant and anticandidal activities of T terrestris in vitro. Both the fruit and aerial parts of the T terrestris extract showed a significant cytotoxic effects in ... -
Direct and protective effects of single or combined addition of vincristine and epsilon-viniferin on human HepG2 cellular oxidative stress markers in vitro
Tarhan, Seda; Özdemir, Filiz; Seller, Zerrin; Demirkan, Emine Sutken (Springer, 2016)The objective of this study is to examine the direct effects of low doses and high doses of epsilon-viniferin, a substance known to be an antioxidant, and vincristine sulphate, a chemotherapeutic agent, alone and in ... -
The effects of 1,3 bis (heteroaryl substitued) benzene derivatives on apoptosis of N-ras transformed mouse skeletal muscle cell [1,3-Bi·s (heteroari·l sübsti·tüe) benzen türevleri·ni·n N-ras transform fare kasi hücre apoptozu üzeri·ne etki·leri·]
Akalın Çiftçi, Gülsen; Seller, Zerrin (2005)Increasing number of the cells, results of excess divicing of the cells, is balanced by apoptosis which causes elimination of old cells and unfunctional cells. Apoptosis is a programmed cell death obtaining this balance. ... -
The effects of carvacrol on apoptosis of H-ras and N-ras transformed cell lines
Akalın Çiftçi, Gülsen; Seller, Zerrin (2011)Fenolik bir monoterpen olan karvakrol kekik bitkisinde bulunmaktadır ve besinlerde baharat olarak kullanılmaktadır. Bu çalışmanın amacı, karvakrol’ün H-ras transform edilmiş 5RP7 ve N-ras transform edilmiş CO25 hücreleri ... -
The effects of carvacrol on apoptosis of H-ras and N-ras transformed cell lines [Karvakrol'ün H-ras ve N-ras transform hücre apoptozu üzerine etkileri]
Akalın Çiftçi, Gülsen; Seller, Zerrin (2011)Carvacrol is a phenolic monoterpen found in Thyme plant which is used as a source of flavour in food. The aim of this study was to investigate apoptotic effects of carvacrol on H-ras transformed 5RP7 and N-ras transformed ... -
Effects of fibronectin and type IV collagen on osteosarcoma cell apoptosis
Seller, Zerrin; Hatipoğlu, İbrahim; Sivas, Hülya; Ergene, Emel; Çiftçi, Gülsen Akalın (Natl Inst Science Communication-Niscair, 2013)The aims of this study are the investigation of the effects of fibronectin and type IV collagen extracellular matrix proteins and the role of caspase-3 and -9 on cis-platin induced U2-OS apoptosis were studied. First the ... -
The effects of some phenanthroline ruthenium (II) complexes on a549 cell proliferation
Ruthenium (II) komplekslerinin DNA bağlanması He ilgili olan yüksek antitumor aktiviteleri nedeni He bu bileşikler son yıllarda araştırmacıların yoğun ilgisini çekmektedir. Bu çalismada imidazo[4,5-f][ 1,10]fenantrolin ...