Konu "Enzyme Inhibition" için Eczacılık Fakültesi listeleme
Toplam kayıt 19, listelenen: 1-19
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Antidiabetic potential: In vitro inhibition effects of bromophenol and diarylmethanones derivatives on metabolic enzymes
(Wiley-V C H Verlag GMBH, 2018)Aldose reductase converts glucose to sorbitol in the polyol pathway. It is an important enzyme to prevent diabetic complications. In this study, we studied the inhibitory effects of bromophenol derivatives on aldose reductase ... -
Antiepileptic drugs: Impacts on human serum paraoxonase-1
(Wiley, 2017)Serum paraoxonase (PON1) is a key enzyme related to high-density lipoprotein (HDL)-cholesterol particle. It can prevent the oxidation of low-density lipoprotein (LDL) and HDL. The present article focuses on the in vitro ... -
Comparative studies on Turkish and Indian Centella asiatica (L.) Urban (gotu kola) samples for their enzyme inhibitory and antioxidant effects and phytochemical characterization
(Elsevier Science BV, 2013)In this study, enzyme inhibitory and antioxidant activity of the ethanol extracts of Centella asiatica (L.) Urban from Turkey and India was examined and the results were compared to those of the standardized extract of the ... -
Composition and potential of Tanacetum haussknechtii Bornm. Grierson as antioxidant and inhibitor of acetylcholinesterase, tyrosinase, and -amylase enzymes
(Taylor & Francis Inc, 2018)The phytochemical composition of essential oils and extracts of Tanacetum haussknechtii were investigated with GC-FID-MS and LC-MS/MS techniques and evaluated against oxidation, acetylcholinesterase, tyrosinase, and -amylase ... -
Design, synthesis and biological assessment of new thiazolylhydrazine derivatives as selective and reversible hMAO-A inhibitors
(Elsevier France-Editions Scientifiques Medicales Elsevier, 2018)In the recent works, it was shown that numerous thiazolylhydrazine derivatives display hMAO inhibitory activity in the range of micromolar concentration. Hence, in the present study a new series of new thiazole-hydrazines ... -
Development of a CD-MEKC method for investigating the metabolism of tamoxifen by flavin-containing monooxygenases and the inhibitory effects of methimazole, nicotine and DMXAA
(Wiley-Blackwell, 2013)A selective and low-cost CD-MEKC method under acidic conditions was developed for investigating the N-oxygenation of tamoxifen (TAM) by flavin-containing monooxygenases (FMOs). The inhibitory effects of methimazole (MMI), ... -
Discovery of potent carbonic anhydrase, acetylcholinesterase, and butyrylcholinesterase enzymes inhibitors: The new amides and thiazolidine-4-ones synthesized on an acetophenone base
(Wiley, 2017)Compounds containing nitrogen and sulfur atoms can be widely used in various fields, including industry, medicine, biotechnology, and chemical technology. Among them, amides of acids and heterocyclic compounds have an ... -
Enzyme inhibitory and antioxidant activity of Melia azedarach L. naturalized in Anatolia and its phenolic acid and fatty acid composition
(Elsevier Science BV, 2012)In the present study, acetylcholinesterase (AChE), butyrylcholinesterase (BChE), and tyrosinase inhibitory and antioxidant activities of the fruit and leaf extracts of Melia azedarach L (Meliaceae) of Turkish origin were ... -
Inhibition properties of some flavonoids on carbonic anhydrase I and II isoenzymes purified from human erythrocytes
(Wiley, 2017)Carbonic anhydrases (CAs, E.C.4.2.1.1) play a critical role in many important physiological events and treatment of some diseases. Flavonoids or phenolic compounds have been discovered as novel CAs inhibitors instead of ... -
Investigation of monoamine oxidase inhibitory activities of new chalcone derivatives
(Çukurova University, Fac Medicine, 2018)Purpose: In the present study, it is aimed to investigate monoamine oxidase (MAO) enzyme inhibition potencies of some new chalcone derivatives. Materials and Methods: Nine novel chalcone derivatives were synthesized and ... -
Phenolic acid profile and in vitro neurobiological effect of phlomis grandiflora H.S. Thompson var. Grandiflora
(Chemical Society of Pakistan, 2018)Neurodegenerative diseases e.g. Alzheimer’s disease (AD) and Parkinson’s disease (PD) are on increase particularly among elderly population and the drugs available are only able to provide symptomatic treatment. Hence, an ... -
Phenolic Acid Profile and in vitro Neurobiological Effect of Phlomis grandiflora HS Thompson var. grandiflora
(Chem Soc Pakistan, 2018)Neurodegenerative diseases e.g. Alzheimer's disease (AD) and Parkinson's disease (PD) are on increase particularly among elderly population and the drugs available are only able to provide symptomatic treatment. Hence, an ... -
Phytochemical Characterization of Phagnalon graecum Boiss. by HPLC and GC-MS with its Enzyme Inhibitory and Antioxidant Activity Profiling by Spectrophotometric Methods
(Springer, 2013)In the current study, the n-hexane, chloroform, ethyl acetate, methanol, and water extracts of Phagnalon graecum Boiss. (Asteraceae), a spice plant, were investigated for their enzyme inhibitory activity against ... -
Phytochemical contents and enzyme inhibitory and antioxidant properties of Anethum graveolens L. (dill) samples cultivated under organic and conventional agricultural conditions
(Pergamon-Elsevier Science LTD, 2013)Inhibitory effect of the n-hexane, dichloromethane, ethyl acetate, and ethanol extracts from Anethum graveolens L. (dill) cultivated under organic (AG-O) and conventional (AG-C) conditions was tested against acetylcholinesterase ... -
Profiling of in vitro neurobiological effects and phenolic acids of selected endemic Salvia species
(Elsevier Sci LTD, 2012)The ethyl acetate and methanol extracts from 16 Salvia L species were screened for their inhibitory activity against acetylcholinesterase, butyrylcholinesterase, lipoxygenase, and tyrosinase; the enzymes linked to ... -
Purification of glutathione reductase from some tissues of Capoeta umblaand the inhibitory effects of some metal ions on enzyme activity
(2021)The aim of this study was to determine the in vitro inhibitory effects of some metal ions (silver ion (Ag+), cadmium ion (Cd2+), cobalt ion (Co2+), copper ion (Cu2+), nickel ion (Ni2+), lead ion (Pb2+) ... -
Synthesis and AChE Inhibitory Activity of Novel Thiazolylhydrazone Derivatives
(MDPI, 2019)Alzheimer's disease (AD) is the most common of the degenerative brain diseases and is described together with the impairment of cognitive function. Patients with AD lose the capability to code new memories, and life ... -
Synthesis and MAO inhibitory activity of novel thiazole-hydrazones
(Scientific Technical Research Council Turkey-Tubitak, 2017)A series of new thiazole-hydrazones (3a-3n) were synthesized, characterized, and screened for their hMAO-A and hMAO-B inhibitory activity by an in vitro fluorometric method. Selectivity indexes (SIs) were expressed as IC50 ... -
Tannic acid as a natural antioxidant compound: Discovery of a potent metabolic enzyme inhibitor for a new therapeutic approach in diabetes and Alzheimer's disease
(Wiley, 2019)Multiple studies have been recorded on the synthesis and design of multi-aim anti-Alzheimer molecules. Using dual butyrylcholinesterase/acetylcholinesterase inhibitor molecules has attracted more interest in the therapy ...