Konu "Inhibition" için Eczacılık Fakültesi listeleme
Toplam kayıt 20, listelenen: 1-20
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Anti-diabetic Properties of Calcium Channel Blockers: Inhibition Effects on Aldose Reductase Enzyme Activity
(Springer, 2019)Aldose reductase (AR) belongs to NADPH-dependent oxidoreductases and converts glucose to sorbitol in the polyol pathway. AR inhibition is essential to prevent diabetic complications. Here, AR was purified from sheep kidney ... -
Assessment of the inhibitory effects and molecular docking of some sulfonamides on human serum paraoxonase 1
(Wiley, 2017)Paraoxonase-1 (PON1) is an organophosphate hydrolyzer and antiatherogenic enzyme. Due to the PON1's crucial functions, inhibitors and activators of PON1 must be known for pharmacological applications. In this study, we ... -
The behavior of some chalcones on acetylcholinesterase and carbonic anhydrase activity
(Taylor and Francis Ltd, 2019)Carbonic anhydrase (CA) has a key role in respiration, carbon dioxide and bicarbonate transport. Acetylcholinesterase (AChE) is a serine hydrolase and mostly abundant at neuromuscular junctions and cholinergic brain synapses. ... -
The effects of some cephalosporins on acetylcholinesterase and glutathione S-transferase: an in vivo and in vitro study
(Taylor & Francis LTD, 2019)Background: Glutathione S-transferase (GST) and acetylcholinesterase (AChE) are important enzymes in the metabolism. GSTs are primarily available in phase II metabolism. AChE is vital for neurodegenerative disorders. ... -
Evaluation of chalcones as inhibitors of glutathione S-transferase
(Wiley, 2018)Glutathione S-transferases (GSTs) are the superfamily of multifunctional detoxification isoenzymes and play an important role in cellular signaling. In the present study, potential inhibition effects of chalcones were ... -
Gadolinium-based contrast agents: in vitro paraoxonase 1 inhibition, in silico studies
(Taylor & Francis LTD, 2019)Medications show their biological effects by interaction with enzymes, which have been known to play an essential role in the pathogenesis of many diseases. Inhibition or induction of drug metabolizing enzymes has an ... -
Hypotensive effects of carvacrol on the blood pressure of normotensive rats
(Georg Thieme Verlag Kg, 2007)Carvacrol is the major compound of essential oils of many plants, ethnomedically used for centuries but there were no detailed investigations on its action on the cardiovascular system. The aim of our study was to investigate ... -
In vitro toxicity effects of some insecticides on gilthead sea bream (Sparus aurata) liver glucose 6-phosphate dehydrogenase
(Nobel Science and Research Center, 2016)In this study, effects of some insecticides (cypermethrin, deltamethrin, dichlorvos, imidacloprid and lambda-cyhalothrin) on glucose 6-phosphate dehydrogenase (D-glucose-6-phosphate: NADP+ oksidoreductase, EC 1.1.1.49; ... -
Inhibition behaviours of some phenolic acids on rat kidney aldose reductase enzyme: an in vitro study
(Taylor & Francis LTD, 2017)Aldose reductase (AR) inhibitors have vital importance in the treatment and prevention of diabetic complications. In this study, rat kidney AR was purified 19.34-fold with a yield of 3.49% and a specific activity of 0.88 ... -
Inhibition effects of pesticides on glutathione-S-transferase enzyme activity of Van Lake fish liver
(Wiley, 2018)Glutathione-S-transferases (GSTs) have a function in xenobiotic metabolism. They are a significant multifunctional family with a wide variety of catalytic activities. In the current study, we determined in vitro inhibition ... -
Inhibition effects of quinones on aldose reductase: Antidiabetic properties
(Elsevier, 2019)Diabetes mellitus is a chronic metabolic disease characterized by abnormal glucose metabolism. Aldose reductase (AR) is the first enzyme in the polyol pathway and converts glucose to sorbitol. It plays a vital role as a ... -
Inhibition of Human Serum Paraoxonase-I with Antimycotic Drugs: In Vitro and In Silico Studies
(Humana Press Inc., 2019)Drugs show their pharmacological effects by inhibiting or activating enzymes. Therefore, enzyme inhibitors have an essential place in the drug design for numerous different sorts of diseases, i.e., cardiovascular, cancer, ... -
The interactions of cephalosporins on polyol pathway enzymes from sheep kidney
(Taylor & Francis LTD, 2018)Context: Cephalosporins are derived from the fungus Acremonium. Due to their strong bactericidal ability, these drugs have to a wide usage in medicine.Objective: An investigation of the effects on sheep renal aldose reductase ... -
Mechanism of capsaicin inhibition of aldose reductase activity
(Wiley, 2017)Aldose reductase (AR) inhibitors play a vital importance as a potential therapeutic and preventive medicine when it comes to hyperglycemia associated diabetic complications. Additionally, capsaicin is used as a food additive ... -
Phenolic compounds inhibit the aldose reductase enzyme from the sheep kidney
(Wiley, 2017)Aldose reductase (AR) is the key enzyme for the polyol pathway and responsible for sorbitol accumulation during the hyperglycemia. The present article focuses on the role of phenol, pyrogallol, hydroquinone, resorcinol, ... -
Phenolic compounds: The inhibition effect on polyol pathway enzymes
(Elsevier Ireland LTD, 2017)The polyol pathway called as sorbitol way is a small part of glycose metabolism. The pathway is regarded as an important element in the pathogenesis of various diabetic complications in individuals with diabetes mellitus. ... -
Purification and characterization of nitric oxide synthase from bovine kidney and investigating drug-induced toxicities of some antibiotics on the enzyme activity
(Bentham Science Publishers B.V., 2017)Introduction: Broad spectrums of antibiotics are widely used in the treatment of bacterial infections, particularly causing Staphylococcus aureus. These drugs have high acute renal injury (AKI) potency due to an increase ... -
Purification of Glucose 6-Phosphate Dehydrogenase From Gilthead Sea Bream (Sparus Aurata) Gill and Liver Tissues and Inhibition Effects of Some Metal Ions on Enzyme Activity
(Parlar Scientific Publications (PSP), 2017)Fish is one of the most valuable protein sources and vulnerable to all environmental pollution including metals. Metals play vital roles in enzyme activities and other metabolic events with their bioaccumulative and ... -
Purification of glucose 6-phosphate dehydrogenase from gilthead sea bream (Sparus aurata) gill and liver tissues and inhibition effects of some metal ions on enzyme activity
(Parlar Scientific Publications, 2017)Fish is one of the most valuable protein sources and vulnerable to all environmental pollution including metals. Metals play vital roles in enzyme activities and other metabolic events with their bioaccumulative and ... -
Synthesis of new piperazine compounds and investigation of their anticholinesterase effects
(Çukurova University, Fac Medicine, 2017)Purpose: The aim of present study is to evaluate anticholinesterase activities of some new piperazine compounds. Materials and Methods: Ten new piperazine derivatives were synthesized. Structure elucidation of the synthesized ...