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Toplam kayıt 55, listelenen: 1-10
Characterization of Solid Lipid Nanoparticles Containing Caffeic Acid and Determination of its Effects on MCF-7 Cells
(Bentham Science Publ LTD, 2015)
Many anticancer drugs that are currently used in cancer treatment are natural products or their analogues by structural modification. Caffeic acid (3, 4-dihydroxycinnamic acid; CA) is classified as hydroxycinnamic acid and ...
A preliminary investigation of anticancer activity of novel benzothiazole derivatives against A549 lung carcinoma cell line
(Walter De Gruyter GMBH, 2017)
Objective(s): In this study, it was aimed to synthesize new chemotherapeutic agents based on known antiproliferative properties of benzothiazol-2-amine moiety. The antitumor activity of the newly synthesized compounds was ...
New N'-Arylidene-2-[(4-Nitrophenyl) Piperazin-1-yl]Acetohydrazide Derivatives: Synthesis and Anticancer Activity Investigation
(Bentham Science Publ LTD, 2017)
Background: Compounds bearing ortho-hydroxy N-acyl hydrazone moiety have been reported with high anticancer activity acting by increasing the enzymatic activity of procaspase-3 in cancer cells and therefore inducing apoptosis ...
Design, synthesis and in vitro evaluation of new thiosemicarbazone derivatives as potential anticancer agents
(Marmara University, 2019)
Thiosemicarbazones play a pivotal role as potential therapeutic agents for the management of lung cancer. 4-(4-Cyanophenyl)-1-[(5-arylfuran-2-yl)methylene]thiosemicarbazides (1-10) were obtained via the reaction of ...
Biological Activity Evaluation of Novel 1,2,4-Triazine Derivatives Containing Thiazole/Benzothiazole Rings
(Bentham Science Publ LTD, 2017)
Background: Triazine ring is a prominent structural motif found in some azanucleosides whose efficiency improved many times in the research area of antitumor agents. Objective: In this study, we have designed and synthesized ...
Design, synthesis and biological evaluation of a new series of thiazolyl-pyrazolines as dual EGFR and HER2 inhibitors
(Elsevier Masson SAS, 2019)
Epidermal growth factor receptor (EGFR, also known as HER1) and HER2, prominent members of receptor tyrosine kinase (RTK) superfamily, have been reported as diagnostic or prognostic markers in tumor progression. Based on ...
New Thiazoline-Tetralin Derivatives and Biological Activity Evaluation
(MDPI AG, 2018)
In this study, novel N-(3-cyclohexyl/phenyl-4-(substituted phenyl)thiazole-2(3H)-ylidene)-2-[(5,6,7,8-tetrahydronaphthalen-2-yl)oxy]acetohydrazide (4a-4k) derivatives were synthesized and their anticancer potency were ...
Synthesis and Evaluation of New Pyrazoline Derivatives as Potential Anticancer Agents
(MDPI AG, 2015)
New pyrazoline derivatives were synthesized and evaluated for their cytotoxic effects on AsPC-1 human pancreatic adenocarcinoma, U87 and U251 human glioblastoma cell lines. 1-[((5-(4-Methylphenyl)-1,3,4-oxadiazol-2-yl)th ...
Evaluation of synergistic anticandidal and apoptotic effects of ferulic acid and caspofungin against Candida albicans
(Food & Drug Adminstration, 2018)
This study aimed to investigate the synergy between anticandidal and apoptotic effects of ferulic acid and caspofungin against Candida albicans and Candida glabrata, with the help of a quantitative checkerboard microdilution ...