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dc.contributor.authorTikiz, Hakan
dc.contributor.authorTunçel, Neşe
dc.contributor.authorAkın, Mehmet Zinnur
dc.contributor.authorGürer, Firdevs
dc.date.accessioned2019-10-22T20:08:20Z
dc.date.available2019-10-22T20:08:20Z
dc.date.issued1992
dc.identifier.issn0196-9781
dc.identifier.urihttps://dx.doi.org/10.1016/0196-9781(92)90144-R
dc.identifier.urihttps://hdl.handle.net/11421/22535
dc.descriptionPubMed: 1620661en_US
dc.description.abstractIn this experiment, the effects of different doses of vasoactive intestinal peptide (VIP) and naloxone (NLX) combinations on survival rates were investigated in rats exposed to 40% hemorrhage. A combination of 25 ng · kg-1 VIP + 5 mg · kg-1 NLX showed the best results on survival. The important prospect of this combination is to have the most potent inhibitory effect on mast cell degranulation. When this combination was given together with shed blood reperfusion and 7.5% NaCl, survival rate increased relative to the administration of shed blood alone and of 7.5% NaCl. These findings suggest that inhibition of mast cell degranulation has a beneficial effect on severe hemorrhageen_US
dc.language.isoengen_US
dc.relation.isversionof10.1016/0196-9781(92)90144-Ren_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectHistamineen_US
dc.subjectMast Cellen_US
dc.subjectNaloxoneen_US
dc.subjectSevere Hemorrhageen_US
dc.subjectVasoactive Intestinal Peptideen_US
dc.titleThe effect of vasoactive intestinal peptide (VIP) and naloxone combination on survival rates in rats exposed to severe hemorrhageen_US
dc.typearticleen_US
dc.relation.journalPeptidesen_US
dc.contributor.departmentAnadolu Üniversitesi, Tıp Fakültesi, Fizyoloji Anabilim Dalıen_US
dc.identifier.volume13en_US
dc.identifier.issue1en_US
dc.identifier.startpage83en_US
dc.identifier.endpage89en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US]
dc.contributor.institutionauthorTikiz, Hakan
dc.contributor.institutionauthorAkın, Mehmet Zinnur


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