Browsing PubMed İndeksli Yayınlar Koleksiyonu by Author "Ak, Dilek"
Now showing items 1-19 of 19
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The antioxidants ?-lipoic acid and N-acetylcysteine reverse memory impairment and brain oxidative stress in aged SAMP8 mice
Farr, S. A.; Poon, H. F.; Ak, Dilek; Drake, J.; Banks, W. A.; Eyerman, E.; Morley, J. E. (2003)Oxidative stress may play a crucial role in age-related neurodegenerative disorders. Here, we examined the ability of two antioxidants, ?-lipoic acid (LA) and N-acetylcysteine (NAC), to reverse the cognitive deficits found ... -
The antioxidants alpha-lipoic acid and N-acetylcysteine reverse memory impairment and brain oxidative stress in aged SAMP8 mice
Farr, SA; Poon, HF; Ak, Dilek; Drake, J; Banks, WA; Eyerman, E; Morley, JE (Blackwell Publishing LTD, 2003)Oxidative stress may play a crucial role in age-related neurodegenerative disorders. Here, we examined the ability of two antioxidants, alpha-lipoic acid (LA) and N -acetylcysteine (NAC), to reverse the cognitive deficits ... -
Contribution of peroxynitrite to the beneficial effects of preconditioning on ischaemia-induced arrhythmias in rat isolated hearts
Altup, S.; Demiryürek, A. T.; Ak, Dilek; Tunçel, Muzaffer; Kanzk, L. (2001)We studied the effects of urate, a peroxynitrite scavenger, on ischaemia- and peroxynitrite-induced preconditioning in rat isolated hearts. Isolated hearts perfused with Krebs-Henseleit solution were preconditioned either ... -
Determination of lansoprazole in pharmaceutical capsules by flow injection analysis using UV-detection
Yeniceli, Duygu; Ak, Dilek; Tunçel, Muzaffer (2004)The direct determination of lansoprazole by using a flow injection analysis (FIA) with UV-detection and its application to the pharmaceutical capsules is described, in this study. The best carrier solvent was found to be ... -
Determination of leflunomide in tablets by high performance liquid chromatography
Yeniceli, Duygu; Ak, Dilek; Tunçel, Muzaffer (Elsevier Science BV, 2006)In the present study, a reverse phase high performance liquid chromatography (HPLC) method was validated and applied for the determination of leflunomide in tablets. Chromatographic separation of leflunomide and oxazepam ... -
Development of a CD-MEKC method for investigating the metabolism of tamoxifen by flavin-containing monooxygenases and the inhibitory effects of methimazole, nicotine and DMXAA
Yeniceli, Duygu; Deng, Xiaolan; Adams, Erwin; Ak, Dilek; Van Schepdael, Ann (Wiley-Blackwell, 2013)A selective and low-cost CD-MEKC method under acidic conditions was developed for investigating the N-oxygenation of tamoxifen (TAM) by flavin-containing monooxygenases (FMOs). The inhibitory effects of methimazole (MMI), ... -
The Effects of Vasoactive Intestinal Peptide on Dura Mater Nitric Oxide Levels and Vessel-Contraction Responses in Sympathectomized Rats
Töre, Fatma; Korkmaz, Orhan Tansel; Ak, Dilek; Tuncel, Neşe (Humana Press Inc, 2010)Nitric oxide (NO) and neurogenic inflammation in dura mater due to nociceptor activation has been implicated for pathophysiology of primary headache disorders. Development of migraine has also been observed in patients ... -
Establishment and characterization of new murine breast cancer cell lines
The establishment of two new breast cancer cell lines, MXT+ and MXT-, derived from the murine breast cancer models MXT-M-3,2 MC (hormone-sensitive) and MXT-M-3,2 (ovex) MC (hormone-insensitive), is described. Characterization ... -
Isolation of peptide transport system-6 from brain endothelial cells: therapeutic effects with antisense inhibition in Alzheimer and stroke models
Ak, Dilek; Kumar, Vijaya B.; Ryerse, Jan S.; Farr, Susan A.; Verma, Şulekha; Nonaka, Naoko; Banks, William A. (Sage Publications Inc, 2009)By isolating for the first time ever a peptide transporter from the blood-brain barrier (BBB) and developing an antisense that selectively targets the brain-to-blood efflux component, we were able to deliver a therapeutic ... -
Modified method for the determination of capillary electrophoresis nitric oxide-correlated nitrate in tissue homogenates
Tunçel, Muzaffer; Ak, Dilek; Erkasap, Nilüfer (2001)A modified capillary electrophoretic method for the determination of nitric oxide correlated nitrate in several tissue homogenates is described in this study. The method was developed using a running buffer consisting of ... -
Passage of vasoactive intestinal peptide across the blood-brain barrier
Ak, Dilek; Banks, WA; Tuncel, N; Tunçel, Muzaffer (Elsevier Science Inc, 2003)We investigated the ability of vasoactive intestinal peptide (VIP) to cross the blood-brain barrier (BBB), the interface between the peripheral circulation and central nervous system (CNS). VIP labeled with I-131 (I-VIP) ... -
Passage of VIP/PACAP/secretin family across the blood-brain barrier: Therapeutic effects
In recent years, VIP/PACAP/secretin family has special interest. Family members are vasoactive intestinal peptide (VIP), pituitary adenylate cyclase-activating polypeptide (PACAP), secretin, glucagon, glucagon like peptide-1 ... -
The protective effect of vasoactive intestinal peptide (VIP) on stress-induced gastric ulceration in rats
Tunçel, N.; Erkasap, N.; Şahintürk, V.; Ak, Dilek; Tunçel, Muzaffer (New York Academy of Sciences, 1998)The pathogenesis of cold restraint stress ulcer involves various factors and is not completely understood. Mast cell degranulation, increased gastric muscular contractility, diminished mucosal blood flow, release of several ... -
Protective effect of vasoactive intestinal peptide on testicular torsion-detorsion injury: Association with heparin-containing mast cells
Can, C; Töre, F; Tuncel, N; Uysal, Oktay; Gürer, G; Ak, Dilek; Tuncel, M (Elsevier Science Inc, 2004)Objectives. To elucidate the action of vasoactive intestinal peptide (VIP) on detorsion injury and the heterogeneity of mast cells in the testes of rats. Methods. Prepubertal male Sprague-Dawley rats were used in six groups. ... -
A simple and sensitive LC-ESI-MS (ion trap) method for the determination of bupropion and its major metabolite, hydroxybupropion in rat plasma and brain microdialysates
Yeniceli, Duygu; Şener, Erol; Korkmaz, Orhan Tansel; Ak, Dilek; Tuncel, Neşe (Elsevier Science BV, 2011)A specific and highly sensitive liquid chromatography-electrospray mass spectrometry (LC-ESI-MS) method for the direct determination of bupropion (BUP) and its main metabolite hydroxybupropion (HBUP) in rat plasma and brain ... -
Validated analysis of fluvastatin in a pharmaceutical capsule formulation and serum by capillary electrophoresis
The capillary electrophoretic behavior and the determination of fluvastatin (FLU) in capsule and serum is described in this study. Method development was conducted in a fused-silica capillary (L = 86 cm, Leff = 58 cm and ... -
Validated Method for the Determination of Piroxicam by Capillary Zone Electrophoresis and Its Application to Tablets
Dal, Arın Gül; Oktayer, Zeynep; Ak, Dilek (Hindawi Publishing Corporation, 2014)Simple and rapid capillary zone electrophoretic method was developed and validated in this study for the determination of piroxicam in tablets. The separation of piroxicam was conducted in a fused-silica capillary by using ... -
Vasoactive intestinal peptide inhibits degranulation and changes granular content of mast cells: A potential therapeutic strategy in controlling septic shock
Tunçel, N.; Töre, Fatma; Şahintürk, V.; Ak, Dilek; Tunçel, Muzaffer (2000)Vasoactive intestinal peptide (VIP) has potent protective activity against sepsis and increases the survival rate of septic rats and mice. The present study was planned to evaluate the effect of VIP on mast cell activity, ... -
Voltammetry of trazodone by platinum electrode and its determination in tablets using DP technique in the rotating conditions
Ak, Dilek; Zaimoğlu, V.; Tunçel, Muzaffer (1999)The voltammetric behaviors of trazodone using a platinum electrode in stationary or rotating conditions and its determination in tablets by DP rotating electrodes are described in this study. The experiments were conducted ...