Yazar "Akalın Çiftçi, Gülsen" için PubMed İndeksli Yayınlar Koleksiyonu listeleme
-
Anticancer Activity of Some Bisbenzimidazoles
Işıkdağ, İlhan; Özkay, Yusuf; İncesu, Zerrin; Akalın Çiftçi, Gülsen (Verlag Z Naturforsch, 2011)The discovery of DNA topoisomerases has added a new dimension to the study of anticancer drugs. Bishenzimidazole derivatives are important compounds known as DNA topoisomerase 1 inhibitors. In the present study, some ... -
Chemical Composition and Biological Activity of Centaurea baseri: New Species from Turkey
Köse, Yavuz Bülent; İşcan, Gökalp; Göğer, Fatih; Akalın Çiftçi, Gülsen; Demirci, Betül; Başer, K. Hüsnü Can (Wiley-V C H Verlag GMBH, 2016)The genus Centaurea L. is one of the largest and important genera of Asteraceae family. Centaurea species have been widely used as herbal remedies in folk medicine for their antidandruff, antidiarrheic, antirheumatic, ... -
Synthesis and anti-Candida activity of novel 2-hydrazino-1,3-thiazole derivatives
Maillard, Ludovic T.; Bertout, Sebastien; QuinÖnero, Ophelie; Akalın Çiftçi, Gülsen; Turan, Gülhanulan; Fulcrand, Pierre; Masurier, Nicolas (Pergamon-Elsevier Science LTD, 2013)Eighteen new hydrazino-1,3-thiazole derivatives were evaluated against 8 strains of multi-resistant Candida spp. Introduction of an indolyl moiety linked to the hydrazone function enhanced the in vitro anti-Candida activity, ... -
Synthesis and anticandidal activity of new triazolothiadiazine derivatives
Altıntop, Mehlika Dilek; Kaplancıklı, Zafer Asım; Turan, Gülhan; Özdemir, Ahmet; İşcan, Gökalp; Akalın Çiftçi, Gülsen; Yıldırım, Şafak Ulusoylar (Elsevier France-Editions Scientifiques Medicales Elsevier, 2011)New triazolothiadiazine derivatives were synthesized via the ring closure reaction of 4-amino-5-substituted-2,4-dihydro-3H-1,2,4-triazol-3-thiones with phenacyl bromides. The compounds were tested in vitro against various ... -
Synthesis and Anticholinesterase Activity and Cytotoxicity of Novel Amide Derivatives
Altıntop, Mehlika Dilek; Kaplancıklı, Zafer Asım; Özdemir, Ahmet; Turan, Gülhan; Temel, Halide Edip; Akalın Çiftçi, Gülsen (Wiley-V C H Verlag GMBH, 2012)In the present study, some amide derivatives were synthesized and their potential anticholinesterase properties were investigated. N-(Benzothiazol-2-yl)-2-[(5-amino/methyl-1,3,4-thiadiazol-2-yl)thio]acetamide derivatives ... -
Synthesis and antituberculosis activity of new thiazolylhydrazone derivatives
Turan, Gülhan; Özdemir, Ahmet; Kaplancıklı, Zafer Asım; Benkli, Kadriye; Chevallet, Pierre; Akalın Çiftçi, Gülsen (Elsevier France-Editions Scientifiques Medicales Elsevier, 2008)The increasing clinical importance of drug-resistant mycobacterial pathogens has lent additional urgency to microbiological research and new antimycobacterial compound development. For this purpose, new thiazolylhydrazone ... -
Synthesis and in vitro Biological Activity of New 4,6-Disubstituted 3(2H)-Pyridazinone-acetohydrazide Derivatives
Şüküroğlu, Murat; Onkol, Tijen; Onurdağ, Fatma Kaynak; Akalın Çiftçi, Gülsen; Şahin, M. Fethi (Verlag Z Naturforsch, 2012)New 3(2H)-pyridazinone derivatives containing a N'-benzyliden-acetohydrazide moiety at position 2 were synthesized. The structures of these newly synthesized compounds were confirmed by IR, H-1 NMR, and MS data. These ... -
Synthesis of 2-substituted-N-[4-(1-methyl-4,5-diphenyl-1H-imidazole-2-yl) phenyl]acetamide derivatives and evaluation of their anticancer activity
Özkay, Yusuf; Işıkdağ, İlhan; Seller, Zerrin; Akalın Çiftçi, Gülsen (Elsevier France-Editions Scientifiques Medicales Elsevier, 2010)In the present study 18 novel imidazole-(benz)azole and imidazole-piperazine derivatives were synthesized in order to investigate their probable anticancer activity. The structures of the compounds were confirmed by IR, ... -
Synthesis, anticandidal activity and cytotoxicity of some tetrazole derivatives
Kaplancıklı, Zafer Asım; Yurttaş, Leyla; Özdemir, Ahmet; Turan, Gülhan; İşcan, Gökalp; Akalın Çiftçi, Gülsen; Abu Mohsen, Usama (Taylor & Francis LTD, 2014)In this study, 14 different 2-[(1-methyl-1H-tetrazole-5-yl)thio]-1-(phenyl) ethanone derivatives (1-14) were synthesized. The structures of the obtained compounds were elucidated using IR, H-1-NMR, C-13-NMR and FAB(+)-MS ... -
Synthesis, antimicrobial activity and cytotoxicity of novel oxadiazole derivatives
Kaplancıklı, Zafer Asım; Altıntop, Mehlika Dilek; Turan, Gülhan; Özdemir, Ahmet; Öziç, Rasime; Akalın Çiftçi, Gülsen (Taylor & Francis LTD, 2012)In the present study, 5-substituted-1,3,4-oxadiazolin-2-thiones (1a-b) were synthesized via the ring closure reactions of appropriate acid hydrazides with carbon disulphide. N-(Benzothiazol-2-yl)-2-[[5-substituted-1,3,4- ... -
Towards Novel Anti-tumor Strategies for Hepatic Cancer: epsilon-Viniferin in Combination with Vincristine Displays Pharmacodynamic Synergy at Lower Doses in HepG2 Cells
Özdemir, Filiz; Akalın Çiftçi, Gülsen; Sen, Mesut; Önder, Nur İpek; İşcan, Arzu; Kutlu, Hatice Mehtap; Seller, Zerrin (Mary Ann Liebert, Inc, 2014)Hepatocellular carcinoma is the fifth most common cancer and the third leading cause of cancer-related deaths worldwide. The efficacy of novel combination treatments are increasingly evaluated with use of integrative biology ...