Yazar "Genç, Lütfi" için PubMed İndeksli Yayınlar Koleksiyonu listeleme
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Assessment of Aprotinin Loaded Microemulsion Formulations for Parenteral Drug Delivery: Preparation, Characterization, in vitro Release and Cytotoxicity Studies
Okur, Neslihan Üstündağ; Özdemir, Derya İlem; Kahyaoğlu, Sennur Görgülü; Şenyiğit, Zeynep Ay; Aşıkoğlu, Makbule; Genç, Lütfi; Karasulu, H. Yeşim (Bentham Science Publ LTD, 2016)The object of the current study was to prepare novel microemulsion formulations of aprotinin for parenteral delivery and to compare in vitro characteristics and release behaviour of different Technetium-99m (Tc-99m)-Aprotinin ... -
Characterization of Solid Lipid Nanoparticles Containing Caffeic Acid and Determination of its Effects on MCF-7 Cells
Dikmen, Gökhan; Güney, Gamze; Genç, Lütfi (Bentham Science Publ LTD, 2015)Many anticancer drugs that are currently used in cancer treatment are natural products or their analogues by structural modification. Caffeic acid (3, 4-dihydroxycinnamic acid; CA) is classified as hydroxycinnamic acid and ... -
Microencapsulation of ketorolac tromethamine by means of a coacervation phase separation technique induced by the addition of non-solvent
Genç, Lütfi; Demirel, Müzeyyen; Güler, E; Hegazy, N (Taylor & Francis LTD, 1998)Ketorolac tromethamine (KT) is a non-steroidal drug with potent analgesic and anti-inflammatory activity and is absorbed rapidly (T-max (1.0h) with an efficiency >87% following oral and intramuscular administration. The ... -
Preparation and characterization of ascorbic acid loaded solid lipid nanoparticles and investigation of their apoptotic effects
Güney, Gamze; Kutlu, Hatice Mehtap; Genç, Lütfi (Elsevier Science BV, 2014)In this paper, ascorbic acid (Vitamin C, AA) known as an antioxidant was successfully incorporated in solid lipid nanoparticles (SLNs) by hot homogenization and efficient delivery of AA to cancer cells. The obtained SLN ... -
Preparation and characterization of methotrexate-loaded microcapsules
Genç, Lütfi; Büyüktiryaki, Sibel (Taylor & Francis LTD, 2014)Methotrexate (MTX) has toxic effect to healthy tissues. Microencapsulation coats particles with a functional coat to optimize storage stability and to modulate release. In the present study, a new MTX encapsulated microcapsules ... -
Preparation and characterization of nocodazole-loaded solid lipid nanoparticles
Genç, Lütfi (Informa Healthcare, 2014)Nocodazole (NCD) has more carcinogenic effect than similar drugs. Moreover, it has low drug release time and high particle size. Solid Lipid Nanoparticles (SLNs) have been evaluated for decrease in particle size and therefore ... -
Preparation and in vitro evaluation of controlled release hydrophilic matrix tablets of ketorolac tromethamine using factorial design
Genç, Lütfi; Jalvand, Esmaeil (Informa Healthcare, 2008)Controlled release matrix tablets of ketorolac tromethamine (KT) were prepared by direct compression technique using cellulose derivatives as hydroxypropylmethyl cellulose (HPMC), hydroxyethyl cellulose (HEC), and carboxymethyl ... -
Preparation of prolonged release clarithromycin microparticles for oral use and their in vitro evaluation
Genç, Lütfi; Demirel, Müzeyyen; Yazan, Yasemin (Pharmaceutical Soc Korea, 2006)Prolonged release microparticles of clarithromycin (CL) were prepared using Eudragit RL 100 and RS 100 by spray-drying and casting-drying techniques. For the characterization of those microparticles, preparation yield, ... -
Studies on controlled release dimenhydrinate from matrix tablet formulations
Genç, Lütfi; Bilaç, H.; Güler, E. (1999)In this study, controlled release dosage forms of dimenhydrinate were prepared with different polymers as MC, HEC, Carbopol 934, Eudragit RLPM and Eudragit NE 30 D at different concentrations (2.5-10%). Direct compression ... -
Studies on vaginal bioadhesive tablets of acyclovir
Genç, Lütfi; Oğuzlar, C; Güler, E (Govi-Verlag GMBH, 2000)Bioadhesive vaginal tablets were prepared using poly(acrylic acid) (PAA); Methylcellulose (MC), carboxymethyl cellulose (CMC), hydroxypropyl cellulose (HPC) and hydroxypropylmethyl cellulose (HPMC) as bioadhesive polymers ... -
Vitamin B-12-loaded solid lipid nanoparticles as a drug carrier in cancer therapy
Genç, Lütfi; Kutlu, Hatice Mehtap; Güney, Gamze (Informa Healthcare, 2015)Nanostructure-mediated drug delivery, a key technology for the realization of nanomedicine, has the potential to improve drug bioavailability, ameliorate release deviation of drug molecules and enable precision drug ...