Kurum Yazarı "Özkay, Yusuf" PubMed İndeksli Yayınlar Koleksiyonu İçin Listeleme
-
Anticancer Activity of Some Bisbenzimidazoles
Işıkdağ, İlhan; Özkay, Yusuf; İncesu, Zerrin; Akalın Çiftçi, Gülsen (Verlag Z Naturforsch, 2011)The discovery of DNA topoisomerases has added a new dimension to the study of anticancer drugs. Bishenzimidazole derivatives are important compounds known as DNA topoisomerase 1 inhibitors. In the present study, some ... -
Antimicrobial activity and a SAR study of some novel benzimidazole derivatives bearing hydrazone moiety
Özkay, Yusuf; Tunalı, Yağmur; Karaca, Hülya; Işıkdağ, İlhan (Elsevier France-Editions Scientifiques Medicales Elsevier, 2010)In this study 12 novel benzimidazole compounds bearing hydrazone moiety were synthesized in order to investigate their possible antibacterial and antifungal activity. Structures of the synthesized compounds were elucidated ... -
Antimicrobial Activity of a New Combination System of Benzimidazole and Various Azoles
Özkay, Yusuf; Tunalı, Yağmur; Karaca, Hülya; Işıkdağ, İlhan (Wiley-Blackwell, 2011)In the present study a new series of benzimidazole derivatives bearing various (benz)azolylthio moieties were synthesized so as to investigate their antimicrobial activity. Structures of the target compounds (5a-5i) were ... -
Antimicrobial Activity of a New Series of Benzimidazole Derivatives
Özkay, Yusuf; Tunalı, Yağmur; Karaca, Hülya; Işıkdağ, İlhan (Pharmaceutical Soc Korea, 2011)Due to antimicrobial importance of benzimidazoles and hydrazones, some benzimidazole-hydrazone compounds were synthesized to screen their antimicrobial activity. Structures of the synthesized compounds were elucidated by ... -
Antiproliferative effects of some N-benzylideneanilines
Özkay, Yusuf; Seller, Zerrin; Işıkdağ, İlhan; Yesilkaya, Mehmet (John Wiley & Sons LTD, 2008)A series of Schiff bases including N-benzylideneaniline (NBA) nuclei were prepared. The chemical products obtained were characterized by mass spectometry (APCI), H-1 NMR, and IR spectroscopy in order to seek their cytotoxic ... -
Design, synthesis and evaluation of new thiazole-piperazines as acetylcholinesterase inhibitors
Yurttaş, Leyla; Kaplancıklı, Zafer Asım; Özkay, Yusuf (Informa Healthcare, 2013)In this study, some new 2-(4-substituted piperazine-1-yl)-N-[4-(2-methylthiazol-4-yl)phenyl]acetamide derivatives were synthesized. The synthesized compounds were screened for their anticholinesterase activity on ... -
Design, synthesis, and AChE inhibitory activity of new benzothiazole-piperazines
Özkay, Ümide Demir; Can, Özgür Devrim; Sağlık, Begüm Nurpelin; Çevik, Ulviye Acar; Levent, Serkan; Özkay, Yusuf; Atlı Eklioğlu, Özlem (Pergamon-Elsevier Science LTD, 2016)In the current study, 14 new benzothiazole-piperazine compounds were designed to meet the structural requirements of acetylcholine esterase (AChE) inhibitors. The target compounds were synthesised in three steps. Structures ... -
Design, synthesis, monoamine oxidase inhibition and docking studies of new dithiocarbamate derivatives bearing benzylamine moiety
Kaya Çavuşoğlu, Betül; Sağlık, Begüm Nurpelin; Özkay, Yusuf; İnci, Beril; Kaplancıklı, Zafer Asım (Academic Press Inc Elsevier Science, 2018)A new series of thirteen 2-[(4-fluorophenyl)(4-nitrobenzyl) amino]-2-oxoethyl-1-substituted-carbodithio ate derivatives (4a-4m) were synthesized and tested for their human monoamine oxidase A and B (hMAO-A and hMAO-B) ... -
Effect of benzothiazole/piperazine derivatives on intracerebroventricular streptozotocin-induced cognitive deficits
Özkay, Ümide Demir; Can, Özgür Devrim; Özkay, Yusuf; Öztürk, Yusuf (Polish Acad Sciences Inst Pharmacology, 2012)Background: In this study, benzothiazolc-piperazine compounds were synthesized by condensing the functional groups of donepezil (DNP), FK-960, and sabeluzole, which are known to have therapeutic potential against Alzheimer's ... -
Mutagenicity of Bisbenzimidazole Derivatives
Alanyalı, Susuz,Filiz; Arıcı, Merve; Artagan, Oge; Işıkdağ, İlhan; Özkay, Yusuf (Verlag Z Naturforsch, 2010)The mutagenicities of 2.2'-(di-3-hydroxyphenyl)-1H,1H'-[5,5']-bisbenzimidazole, 2,2'-(di-4-hydroxyphenyl)-1H,1H'-[5,5']-bisbenzimidazole, 2,2'-(di-3-methoxyphenyl)-1H,1H'-[5.5']-bisbenzimidazole, 2,2'-bis-(4-nitrophenyl) ... -
New 1,4-dihydro[1,8]naphthyridine derivatives as DNA gyrase inhibitors
Karaca Gencer, Hülya; Levent, Serkan; Çevik, Ulviye Acar; Özkay, Yusuf; Ilgın, Sinem (Pergamon-Elsevier Science LTD, 2017)Owing to the growing need for novel antibacterial agents, we synthesized a novel series of fluoroquinolones including 7-substituted-1-(2,4-difluoropheny1)-6-fluoro-4-oxo-1,4-dihydro[1,8]naphthyridine-3-carboxylic acid ... -
New Benzimidazole-1,2,4-Triazole Hybrid Compounds: Synthesis, Anticandidal Activity and Cytotoxicity Evaluation
Karaca Gencer, Hülya; Çevik, Ulviye Acar; Levent, Serkan; Sağlık, Begüm Nurpelin; Korkut, Büşra; Özkay, Yusuf; Öztürk, Yusuf (MDPI AG, 2017)Owing to the growing need for antifungal agents, we synthesized a new series 2-((5-(4-(5-substituted-1H-benzimidazol-2-yl)phenyl)-4-substituted-4H-1,2,4-triazol-3-yl)thio)-1-(substituted phenyl)ethan-1-one derivatives, ... -
Novel 1-(2-pyrimidin-2-yl)piperazine derivatives as selective monoamine oxidase (MAO)-A inhibitors
Kaya, Betül; Yurttaş, Leyla; Sağlık, Begüm Nurpelin; Levent, Serkan; Özkay, Yusuf; Kaplancıklı, Zafer Asım (Taylor & Francis LTD, 2017)In the present study, a new series of 2-[4-(pyrimidin-2-yl) piperazin-1-yl]-2-oxoethyl 4-substituted piperazine- 1-carbodithioate derivatives (2a-n) were synthesized and screened for their monoamine oxidase A and B inhibitory ... -
Pharmacological and Toxicological Screening of Novel Benzimidazole-Morpholine Derivatives as Dual-Acting Inhibitors
Can, Nafiz Öncü; Çevik, Ulviye Acar; Sağlık, Begüm Nurpelin; Özkay, Yusuf; Atlı Eklioğlu, Özlem; Baysal, Merve; Can, Özgür Devrim (MDPI, 2017)The aim of this study was to investigate acetylcholinesterase (AChE), monoamine oxidase A (MAO-A), monoamine oxidase B (MAO-B), cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2) enzyme inhibitory, and antimicrobial ... -
Synthesis and AChE Inhibitory Activity of Novel Thiazolylhydrazone Derivatives
Osmaniye, Derya; Sağlık, Begüm Nurpelin; Acar Çevik, Ulviye; Levent, Serkan; Kaya Çavuşoğlu, Betül; Özkay, Yusuf; Turan, Gülhan (MDPI, 2019)Alzheimer's disease (AD) is the most common of the degenerative brain diseases and is described together with the impairment of cognitive function. Patients with AD lose the capability to code new memories, and life ... -
Synthesis and AChE-Inhibitory Activity of New Benzimidazole Derivatives
Çevik, Ulviye Acar; Sağlık, Begüm Nurpelin; Levent, Serkan; Osmaniye, Derya; Kaya Çavuşoğlu, Betül; Özkay, Yusuf; Kaplancıklı, Zafer Asım (MDPI, 2019)Alzheimer's disease (AD), one of the main causes of aged dementia, is a progressive and degenerative neurological disorder characterized by loss of cognition and memory. Although the symptomatic treatment of AD, particularly ... -
Synthesis and anticancer activity evaluation of N-[4-(2-methylthiazol-4-yl)phenyl]acetamide derivatives containing (benz)azole moiety
Yurttaş, Leyla; Özkay, Yusuf; Akalın-Çiftçi, Gülsen; Ulusoylar-Yıldırım, Şafak (Informa Healthcare, 2014)A new class of novel thiazole-(benz) azole derivatives was synthesized to investigate their anticancer activity. The structure of the compounds was confirmed by IR, H-1-NMR, and MS spectral data and elemental analyses. ... -
Synthesis and antimicrobial activity of some new hydrazone-bridged thiazole-pyrrole derivatives
Yurttaş, Leyla; Özkay, Yusuf; Kaplancıklı, Zafer Asım; Tunalı, Yağmur; Karaca Gencer, Hülya (Taylor & Francis LTD, 2013)In this work, we synthesized fourteen different compounds which contain hydrazone bridged thiazole and pyrrole rings. For this purpose, pyrrole-2-carboxaldehydes were reacted directly with thiosemicarbazide in ethanol and ... -
Synthesis and Biological Evaluation of a Series of Dithiocarbamates as New Cholinesterase Inhibitors
Altıntop, Mehlika Dilek; Gürkan-Alp, A. Selen; Özkay, Yusuf; Kaplancıklı, Zafer Asım (Wiley-V C H Verlag GMBH, 2013)In the present paper, a novel series of dithiocarbamates was synthesized via the treatment of 4-(trifluoromethyl)benzyl chloride with appropriate sodium salts of N,N-disubstituted dithiocarbamic acids. H-1 NMR, mass spectral ... -
Synthesis and Biological Evaluation of New Cholinesterase Inhibitors for Alzheimer's Disease
Hussein, Weiam; Sağlık, Begüm Nurpelin; Levent, Serkan; Korkut, Büsra; Ilgın, Sinem; Özkay, Yusuf; Kaplancıklı, Zafer Asım (MDPI, 2018)Alzheimer's disease (AD) is a neurodegenerative disorder mostly influencing the elderly, and causes death due to dementia. The main pathogenic feature connected with the progression of this multifactorial disease is the ...