Kurum Yazarı "Can, Nafiz Öncü" PubMed İndeksli Yayınlar Koleksiyonu İçin Listeleme
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Design, synthesis and biological assessment of new thiazolylhydrazine derivatives as selective and reversible hMAO-A inhibitors
Can, Nafiz Öncü; Osmaniye, Derya; Levent, Serkan; Sağlık, Begüm Nurpelin; Korkut, Büşra; Atlı Eklioğlu, Özlem; Kaplancıklı, Zafer Asım (Elsevier France-Editions Scientifiques Medicales Elsevier, 2018)In the recent works, it was shown that numerous thiazolylhydrazine derivatives display hMAO inhibitory activity in the range of micromolar concentration. Hence, in the present study a new series of new thiazole-hydrazines ... -
Determination of cefuroxime axetil in tablets and biological fluids using liquid chromatography and flow injection analysis
Can, Nafiz Öncü; Altıokka, Göksel; Aboul-Enein, Hassan Y. (Elsevier Science BV, 2006)Cefuroxime axetil is the pro-drug of cephalosporin cefuroxime that is used in the treatment of common community-acquired infections. A simple and precise liquid chromatographic method for the determination of cefuroxime ... -
The determination of levofloxacin by flow injection analysis using UV detection, potentiometry, and conductometry in pharmaceutical preparations
Altıokka, Göksel; Atkoşar, Zeki; Can, Nafiz Öncü (Pergamon-Elsevier Science LTD, 2002)A flow injection analysis (FIA) using UV detection, potentiometry and conductometry for levofloxacin (LVF) are described in this study. The best solvent system was found to consist of 0.2 V acetate buffer at pH 3 having ... -
Determination of nabumetone in pharmaceutical formulation by flow injection analysis (FIA) with UV-detection
Can, Nafiz Öncü; Tuncel, M; Aboul-Enein, Hassan Y. (Govi-Verlag GMBH, 2003)A precise and accurate FIA method for the quantification of nabumetone (NAB) in pharmaceuticals is described. The best suitable carrier solvent system consisted of ethanol: water (30: 70 v/v). Sample solution (4.7 x 10(-6) ... -
Development of Validated and Stability-Indicating LC-DAD and LC-MS/MS Methods for Determination of Avanafil in Pharmaceutical Preparations and Identification of a Novel Degradation Product by LCMS-IT-TOF
Can, Nafiz Öncü (MDPI, 2018)Avanafil (AVA), one of the most effective drugs prescribed for erectile dysfunction, is a pyrimidine-derivative PDE5 inhibitor. In the current work, new LC methods were developed and validated for quantitative determination ... -
HPLC determination of cefprozil in tablets using monolithic and C-18 silica columns
Can, Nafiz Öncü (Wiley-V C H Verlag GMBH, 2011)Cefprozil (CPZ) is a second-generation semi-synthetic cephalosporin antibiotic that commonly exists as the mixture of Z and E diastereoisomers, at the ratio of approximately 9:1. A novel reversed-phase HPLC method for the ... -
A novel dilute and shoot HPLC assay method for quantification of irbesartan and hydrochlorothiazide in combination tablets and urine using second generation C-18-bonded monolithic silica column with double gradient elution
Koyutürk, Sema; Can, Nafiz Öncü; Atkoşar, Zeki; Arli, Göksel (Elsevier Science BV, 2014)Irbesartan (IRB) and hydrochlorothiazide (HCT) are angiotensin-ll receptor antagonist and thiazide-class diuretic compounds, respectively, which are in use in the treatment of hypertension. A novel diluteand-shoot HPLC ... -
A novel RP-HPLC method for simultaneous determination of potassium sorbate and sodium benzoate in soft drinks using C-18-bonded monolithic silica column
Can, Nafiz Öncü; Arli, Göksel; Lafçı, Yiğit (Wiley Periodicals, Inc, 2011)Potassium sorbate and sodium benzoate are food additives that are generally employed for prevention of food spoilage originating from bacteria, molds or yeasts. Although these compounds were generally recognized as safe ... -
Pharmacological and Toxicological Screening of Novel Benzimidazole-Morpholine Derivatives as Dual-Acting Inhibitors
Can, Nafiz Öncü; Çevik, Ulviye Acar; Sağlık, Begüm Nurpelin; Özkay, Yusuf; Atlı Eklioğlu, Özlem; Baysal, Merve; Can, Özgür Devrim (MDPI, 2017)The aim of this study was to investigate acetylcholinesterase (AChE), monoamine oxidase A (MAO-A), monoamine oxidase B (MAO-B), cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2) enzyme inhibitory, and antimicrobial ... -
Reversed-phase HPLC analysis of levetiracetam in tablets using monolithic and conventional c18 silica column
Can, Nafiz Öncü; Arli, Göksel (2010)Development and validation of an RP-HPLC method for determination of levetiracetam in pharmaceutical tablets is described. The separation and quantification of levetiracetam and caffeine (internal standard) were performed ... -
Reversed-Phase HPLC Analysis of Levetiracetam in Tablets Using Monolithic and Conventional C18 Silica Columns
Can, Nafiz Öncü; Arli, Göksel (Aoac Int, 2010)Development and validation of an RP-HPLC method for determination of levetiracetam in pharmaceutical tablets is described. The separation and quantification of levetiracetam and caffeine (internal standard) were performed ... -
Synthesis of New Hydrazone Derivatives for MAO Enzymes Inhibitory Activity
Can, Nafiz Öncü; Osmaniye, Derya; Levent, Serkan; Sağlık, Begüm Nurpelin; İnci, Beril; Ilgın, Sinem; Kaplancıklı, Zafer Asım (MDPI, 2017)In the present work, 14 new 1-substituted-2-phenylhydrazone derivatives were synthesized to evaluate their inhibitory activity against hMAO enzymes. The structures of the newly synthesized hydrazones 2a-2n were characterized ... -
Synthesis of Some Novel Thiadiazole Derivative Compounds and Screening Their Antidepressant-Like Activities
Can, Nafiz Öncü; Can, Özgür Devrim; Osmaniye, Derya; Özkay, Ümide Demir (MDPI, 2018)Novel thiadiazole derivatives were synthesized through the reaction of acetylated 2-aminothiadiazole and piperazine derivatives. The chemical structures of the compounds were clarified by Infrared Spectroscopy (IR), H-1 ...