Kurum Yazarı "Ilgın, Sinem" PubMed İndeksli Yayınlar Koleksiyonu İçin Listeleme
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Acute and Subchronic Toxic Effects of the Fruits of Physalis peruviana L.
Perk, Başak Özlem; Ilgın, Sinem; Atlı Eklioğlu, Özlem; Duymuş, Hale Gamze; Sırmagül, Başar (Hindawi Publishing Corporation, 2013)The fruit of Physalis peruviana L. (PPL) has been traditionally used as antispasmodic, diuretic, antiseptic, sedative, and analgesic all over the world. We aimed to perform qualitative content analysis of the fruits of PPL ... -
Assessment of the Endothelial Functions in Monocrotaline-induced Pulmonary Hypertension
Sırmagül, Başar; Ilgın, Sinem; Atlı Eklioğlu, Özlem; Usanmaz, Suzan Emel; Demirel-Yılmaz, Emine (Taylor & Francis Inc, 2013)Pulmonary hypertension (PH) is a life-threatening disease that causes endothelial dysfunction in the pulmonary vascular bed. Systemic endothelial dysfunction has also been reported in PH. This study compared the systemic ... -
Assessment of trazodone-induced cardiotoxicity after repeated doses in rats
Atlı Eklioğlu, Özlem; Kılıç, Volkan; Baysal, Merve; Aydoğan Kılıç, Gözde; Gormus, G.; Ucarcan, S.; Ilgın, Sinem (SAGE Publications LTD, 2019)Trazodone (TRZ) is an antidepressant drug commonly used in the treatment of depression, anxiety, and insomnia. Although some studies demonstrated the adverse effects of TRZ related to cardiovascular system, the conflicting ... -
Ciprofloxacin-induced neurotoxicity: evaluation of possible underlying mechanisms
Ilgın, Sinem; Can, Özgür Devrim; Atlı Eklioğlu, Özlem; Ucel, Umut İrfan; Şener, Erol; Güven, İlkay (Taylor & Francis LTD, 2015)Ciprofloxacin (CPX) is a fluoroquinolone antibiotic used for treating respiratory, urinary tract, gastrointestinal and abdominal infections. There are only a limited number of studies related to neurological adverse effects ... -
Citalopram Induces Reproductive Toxicity in Male Rats
Ilgın, Sinem; Aydoğan-Kılıc, G.; Baysal, Merve; Kılıç, Volkan; Korkut, Büşra; Uçarcan, Şeyda; Atlı Eklioğlu, Özlem (Wiley, 2017)Background: Citalopram hydrobromide (CTL) has been shown to cause sexual dysfunction; however, its reproductive toxicity potential has not been sufficiently elucidated in men. Therefore, we aimed to clarify the toxic effects ... -
Design and evaluation of biological activities of 1,3-oxazolidinone derivatives bearing amide, sulfonamide, and thiourea moieties
Karaman, Nurcan; Zainel, Rabeah Adil; Kapkac, Handan A.; Karaca Gencer, Hülya; Ilgın, Sinem; Karaduman, Abdullah Burak; Koçyiğit-Kaymakçıoğlu, Bedia (Wiley-V C H Verlag GMBH, 2018)1,3-Oxazolidine-2-one is an important heterocyclic ring participating in the chemical structure of many drugs. In this research, 22 new amide/sulfonamide/thiourea derivatives (1-22) were obtained by the reaction of ... -
Design and Synthesis of New Benzothiazole Compounds as Selective hMAO-B Inhibitors
Ilgın, Sinem; Osmaniye, Derya; Levent, Serkan; Sağlık, Begüm Nurpelin; Çevik, Ulviye Acar; Kaya Çavuşoğlu, Betül; Kaplancıklı, Zafer Asım (MDPI AG, 2017)In the current work a new class of novel benzothiazole-hydrazone derivatives was designed and synthesized as hMAO-B inhibitors. Structures of the obtained compounds (3a-3j) were characterized by IR, 1H-NMR, 13C-NMR, and ... -
The effect of combination therapy on the plasma concentrations of traditional antiepileptics: A retrospective study
Sırmagül, B.; Atlı Eklioğlu, Özlem; Ilgın, Sinem (SAGE Publications LTD, 2012)The present study aimed at determining the differences in plasma concentrations of traditional antiepileptics such as phenytoin, carbamazepine, and valproic acid in patients receiving monotherapy and combination therapy. ... -
Effects of Everolimus in Combination with Sildenafil in Monocrotaline-induced Pulmonary Hypertension in Rats
Ilgın, Sinem; Burukoğlu, Dilek; Atlı Eklioğlu, Özlem; Sırmagül, Başar (Humana Press Inc, 2012)In our study, we investigated the efficacy of everolimus in combination with sildenafil on hemodynamic and morphological parameters in rats with monocrotaline-induced pulmonary hypertension (PH). Right ventricular pressure ... -
The effects of gender difference on monocrotaline-induced pulmonary hypertension in rats
Bal, E.; Ilgın, Sinem; Atlı Eklioğlu, Özlem; Ergün, Bülent; Sırmagül, Başar (SAGE Publications LTD, 2013)The present study aimed to compare the effect of gender difference on hemodynamic consequences in the development of monocrotaline (MCT)-induced pulmonary hypertension in rat. The effect of antioxidant enzyme systems on ... -
Evaluation of azithromycin induced cardiotoxicity in rats
Atlı Eklioğlu, Özlem; Ilgın, Sinem; Altuntaş, Hakan; Burukoğlu, Dilek (E-Century Publishing Corp, 2015)Although there are possible cardiovascular adverse effects associated with the azithromycin treatment according to some case reports and cohort studies, there is no experimental study evaluating cardiotoxicity in repeated ... -
Evaluation of the reproductive toxicity of naproxen sodium and meloxicam in male rats
Uzun, B.; Atlı Eklioğlu, Özlem; Perk, B. O.; Burukoğlu, D.; Ilgın, Sinem (SAGE Publications LTD, 2015)Nonsteroidal anti-inflammatory drugs that are cyclooxygenase (COX) enzyme inhibitors have generally been used in short-term pain management and also to treat inflammation chronically. It is known that COX enzyme and ... -
Evidence for cardiotoxicity associated with sertraline in rats
Ilgın, Sinem; Kılıç, Volkan; Baysal, Merve; Aydoğan Kılıç, Gözde; Uçarcan, Şeyda; Dermenci, Begüm; Atlı Eklioğlu, Özlem (Royal Soc Chemistry, 2018)Sertraline is an antidepressant that is frequently prescribed to treat depression, obsessive-compulsive disorder, panic disorder, and anxiety. This drug had a safe cardiotoxicity profile, until the reporting of cases of ... -
Evidence for neurotoxicity associated with amoxicillin in juvenile rats
Atlı Eklioğlu, Özlem; Demir-Özkay, U.; Ilgın, Sinem; Aydın, T. H.; Akbulut, E. N.; Şener, E. (SAGE Publications LTD, 2016)Amoxicillin (AMX) is one of the most commonly prescribed antibiotics for children, and childhood is the period to have the highest risk for toxicity cases including drug-induced adverse reactions. Some neurological adverse ... -
In vitro and in silico evaluation of new thiazole compounds as monoamine oxidase inhibitors
Sağlık, Begüm Nurpelin; Kaya Çavuşoğlu, Betül; Osmaniye, Derya; Levent, Serkan; Çevik, Ulviye Acar; Ilgın, Sinem; Öztürk, Yusuf (Academic Press Inc Elsevier Science, 2019)New twenty compounds bearing thiazole ring (3a-3t) were designed and synthesized as monoamine oxidase (MAO) inhibitors. The fluorometric enzyme inhibition assay was used to determine the biological effects of synthesized ... -
In vitro antitumor activity evaluation of some 1,2,4-triazine derivatives bearing piperazine amide moiety against breast cancer cells
Yurttaş, Leyla; Demirayak, Şeref; Ilgın, Sinem; Atlı Eklioğlu, Özlem (Pergamon-Elsevier Science LTD, 2014)A series of 1,2,4-triazine derivatives bearing piperazine amide moiety has been synthesized and investigated for their potential anticancer activities. 1-[4-(5,6-Bis(4-subtituted phenyl)-1,2,4-triazin-3-yl) piperazin- ... -
MAO enzymes inhibitory activity of new benzimidazole derivatives including hydrazone and propargyl side chains
Can, Özgür Devrim; Osmaniye, Derya; Özkay, Ümide Demir; Sağlık, Begüm Nurpelin; Levent, Serkan; Ilgın, Sinem; Kaplancıklı, Zafer Asım (Elsevier France-Editions Scientifiques Medicales Elsevier, 2017)In the present work, 15 new N'-(arylidene)-4-(1-(prop-2-yn-1-yl)-1H-benzo[dlimidazol-2-yl)benzohydrazide (4a-4o) were designed and synthesized. The structures of the synthesized compounds were elucidated using FT-IR, ... -
Matrix metalloproteinases are possible targets in monocrotaline-induced pulmonary hypertension: investigation of anti-remodeling effects of alagebrium and everolimus
Atlı Eklioğlu, Özlem; Ilgın, Sinem; Ergün, Bülent; Burukoğlu, Dilek; Musmul, Ahmet; Sırmagül, Başar (Turkish Soc Cardiology, 2017)Objective: In our study, sildenafil alone and everolimus or alagebrium in combination with sildenafil were investigated in terms of their additional therapeutic and anti-remodeling activity in monocrotaline-induced pulmonary ... -
New 1,4-dihydro[1,8]naphthyridine derivatives as DNA gyrase inhibitors
Karaca Gencer, Hülya; Levent, Serkan; Çevik, Ulviye Acar; Özkay, Yusuf; Ilgın, Sinem (Pergamon-Elsevier Science LTD, 2017)Owing to the growing need for novel antibacterial agents, we synthesized a novel series of fluoroquinolones including 7-substituted-1-(2,4-difluoropheny1)-6-fluoro-4-oxo-1,4-dihydro[1,8]naphthyridine-3-carboxylic acid ... -
A novel series of thiazolyl-pyrazoline derivatives: Synthesis and evaluation of antifungal activity, cytotoxicity and genotoxicity
Altıntop, Mehlika Dilek; Özdemir, Ahmet; Turan, Gülhan; Ilgın, Sinem; Atlı Eklioğlu, Özlem; Demirel, Rasime; Kaplancıklı, Zafer Asım (Elsevier France-Editions Scientifiques Medicales Elsevier, 2015)In the current work, new thiazolyl pyrazoline derivatives (1-22) were synthesized and evaluated for their antifungal effects against pathogenic yeasts and molds using a broth microdilution assay. Ames assay was carried out ...